Hair cortisol in twins:heritability and genetic overlap with psychological variables and stress-system genes

Autor: Rietschel, Liz, Streit, Fabian, McGrath, John, Davies, Gareth, Davies, Gail, de Geus, Eco J C, De Jager, Philip, Deary, Ian J, Degenhardt, Franziska, Dunn, Erin C, Ehli, Erik A, Eley, Thalia C, Escott-Price, Valentina, Hickie, Ian B, Esko, Tõnu, Finucane, Hilary K, Gill, Michael, Gordon, Scott D, Grove, Jakob, Hall, Lynsey S, Hansen, Thomas F, Søholm Hansen, Christine, Heath, Andrew C, Hansell, Narelle K, Henders, Anjali K, Herms, Stefan, Hoffmann, Per, Homuth, Georg, Horn, Carsten, Hottenga, Jouke- Jan, Hougaard, David, Huang, Hailiang, Ising, Marcus, Jansen, Rick, Wright, Margaret J, Jorgenson, Eric, Kloiber, Stefan, Knowles, James A, Kretzschmar, Warren W, Krogh, Jesper, Kutalik, Zoltán, Lang, Maren, Lewis, Glyn, Li, Yihan, MacIntyre, Donald J, Gillespie, Nathan A, Madden, Pamela Af, Marchine, Jonathan, Mbarek, Hamdi, McGuffin, Peter, Mehta, Divya, Metspalu, Andres, Middeldorp, Christel M, Mihailov, Evelin, Milani, Lili, Montgomery, Grant W, Forstner, Andreas J, Mostafavi, Sara, Mullins, Niamh, Nauck, Matthias, Ng, Bernard, Nordentoft, Merete, Nyholt, Dale R, O'Donovan, Michael C, O'Reilly, Paul F, Oskarsson, Hogni, Owen, Michael J, Schulze, Thomas G, Paciga, Sara A, Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Pedersen, Nancy L, Pergadia, Michele L, Peterson, Roseann E, Pettersson, Erik, Peyrot, Wouter J, Porteous, David J, Posthuma, Danielle, Wüst, Stefan, Potash, James B, Quiroz, Jorge A, Rice, John P, Riley, Brien P, Rivera, Margarita, Ruderfer, Douglas M, Saeed Mirza, Saira, Schoevers, Robert, Shen, Ling, Shi, Jianxin, Nöthen, Markus M, Sigurdsson, Engilbert, Sinnamon, Grant Cb, Smit, Johannes H, Smith, Daniel J, Smoller, Jordan W, Stephansson, Hreinn, Steinberg, Stacy, Strohmaier, Jana, Tansey, Katherine E, Teumer, Alexander, Baumgartner, Markus R, Thompson, Wesley, Thomson, Pippa A, Thorgeirsson, Thorgeir E, Treutlein, Jens, Trzaskowski, Maciej, Umbricht, Daniel, van der Auwera, Sandra, van Grootheest, Gerard, van Hemert, Albert M, Viktorin, Alexander, Zhu, Gu, Walker, Brian R, Völzke, Henry, Wang, Yunpeng, Webb, Bradley T, Weissman, Myrna M, Wellmann, Jürgen, Willemsen, Gonneke, Xi, Hualin S, Baune, Bernhard T, Blackwood, Douglas H R, Boomsma, Dorret I, Crawford, Andrew A, Børglum, Anders D, Buttenschøn, Henriette N, Cichon, Sven, Domenici, Enrico, Flint, Jonathan, Grabe, Hans J, Hamilton, Steven P, Kendler, Kenneth S, Li, Qingqin S, Lucae, Susanne, Colodro-Conde, Lucía, Magnusson, Patrik K, McIntosh, Andrew M, Mors, Ole, Bo Mortensen, Preben, Müller-Myhsok, Bertram, Penninx, Brenda Wjh, Perlis, Roy H, Preisig, Martin, Schaefer, Catherine, Medland, Sarah E, Stephansson, Kari, Tiemeier, Henning, Uher, Rudolf, Werge, Thomas, Winslow, Ashley R, Breen, Gerome, Levinson, Douglas F, Lewis, Cathryn M, Wray, Naomi R, Sullivan, Patrick F, Martin, Nicholas G, Rietschel, Marcella, Bolton, Jennifer L, Hayward, Caroline, Direk, Nese, Anderson, Anna, McAloney, Kerrie, Huffman, Jennifer, Wilson, James F, Campbell, Harry, Rudan, Igor, Wright, Alan, Hastie, Nicholas, Wild, Sarah H, Velders, Fleur P, Hofman, Albert, Uitterlinden, Andre G, Frank, Josef, Lahti, Jari, Räikkönen, Katri, Kajantie, Eero, Widen, Elisabeth, Palotie, Aarno, Eriksson, Johan G, Kaakinen, Marika, Järvelin, Marjo-Riitta, Timpson, Nicholas J, Davey Smith, George, Couvy-Duchesne, Baptiste, Ring, Susan M, Evans, David M, St Pourcain, Beate, Tanaka, Toshiko, Milaneschi, Yuri, Bandinelli, Stefania, Ferrucci, Luigi, van der Harst, Pim, Rosmalen, Judith Gm, Bakker, Stephen Jl, Witt, Stephanie H, Verweij, Niek, Dullaart, Robin Pf, Mahajan, Anubha, Lindgren, Cecilia M, Morris, Andrew, Lind, Lars, Ingelsson, Erik, Anderson, Laura N, Pennell, Craig E, Lye, Stephen J, Binz, Tina M, Matthews, Stephen G, Eriksson, Joel, Mellstrom, Dan, Ohlsson, Claes, Price, Jackie F, Strachan, Mark Wj, Reynolds, Rebecca M, Ripke, Stephan, Mattheisen, Manuel, CORtisolNETwork, Abdellaoui, Abdel, Adams, Mark J, Agerbo, Esben, Air, Tracy M, Andlauer, Till Fm, Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan Tf, Bennett, David A, Berger, Klaus, Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics, Bigdeli, Tim B, Bybjerg-Grauholm, Jonas, Byrne, Enda M, Cai, Na, Castelao, Enrique, Clarke, Toni-Kim, Coleman, Jonathan Ri, Consortium, Converge, Craddock, Nick, Dannlowski, Udo

Publikováno v: Scientific Reports, 7(1):15351. Nature Publishing Group
Rietschel, L, Streit, F, Zhu, G, McAloney, K, Frank, J, Couvy-Duchesne, B, Witt, S H, Binz, T M, (CORNET) Consortium & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC) 2017, ' Hair Cortisol in Twins : Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes ', Scientific Reports, vol. 7, no. 1, 15351 . https://doi.org/10.1038/s41598-017-11852-3
Scientific Reports, 7(1). Nature Publishing Group
Rietschel, L, Streit, F, Zhu, G, McAloney, K, Frank, J, Couvy-Duchesne, B, Witt, S H, Binz, T, McGrath, J J, Hickie, I B, Hansell, N K, Wright, M J, Gillespie, N, Forstner, A J, Schulze, T G, Wust, S, Nöthen, M M, Baumgartner, M, Walker, B, Crawford, A, Colodro-Conde, L, Medland, S E, Martin, N G & Rietschel, M 2017, ' Hair cortisol in twins: Heritability and genetic overlap with psychological variables and stress-system genes ', Scientific Reports . https://doi.org/10.1038/s41598-017-11852-3
Scientific Reports
Rietschel, L, Streit, F, Zhu, G, McAloney, K, Frank, J, Couvy-Duchesne, B, Witt, S H, Binz, T M, McGrath, J, Hickie, I B, Hansell, N K, Wright, M J, Gillespie, N A, Forstner, A J, Schulze, T G, Wüst, S, Nöthen, M M, Baumgartner, M R, Walker, B R, Crawford, A A, Colodro-Conde, L, Medland, S E & Martin, N G & Rietschel, M 2017, ' Hair Cortisol in Twins : Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes ', Scientific Reports, vol. 7, 15351 . https://doi.org/10.1038/s41598-017-11852-3
Scientific reports
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific reports 7(1), 15351 (2017). doi:10.1038/s41598-017-11852-3
CORtisolNETwork (CORNET) Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC) & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC) 2017, ' Hair Cortisol in Twins : Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes ', Scientific Reports, vol. 7, 15351 . https://doi.org/10.1038/s41598-017-11852-3
Rietschel, L, Streit, F, Zhu, G, McAloney, K, Frank, J, Couvy-Duchesne, B, Witt, S H, Binz, T M, McGrath, J, Hickie, I B, Hansell, N K, Wright, M J, Gillespie, N A, Forstner, A J, Schulze, T G, Wüst, S, Nöthen, M M, Baumgartner, M R, Walker, B R, Crawford, A A, Colodro-Conde, L, Medland, S E, Martin, N G, Rietschel, M, CORtisolNETwork (CORNET) Consortium, Abdellaoui, A, de Geus, E, Hottenga, J J, Mbarek, H, Middeldorp, C M, Willemsen, G & Boomsma, D I 2017, ' Hair Cortisol in Twins : Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes ', Scientific Reports, vol. 7, no. 1, 15351, pp. 15351 . https://doi.org/10.1038/s41598-017-11852-3
Rietschel, Liz; Streit, F; Zhu, G; McAloney, K; Frank, J; Couvy-Duchesne, B; Witt, SH; Binz, TM; CORtisolNETwork (CORNET), Consortium; Major Depressive Disorder Working Group of the Psychiatric, Genomics Consortium (PGC); McGrath, J; Hickie, I; Hansell, NK; Wright, MJ; Gillespie, NA; Forstner, AJ; Schulze, TG; Wüst, S; Nöthen, MM; Baumgartner, MR; ... (2017). Hair cortisol in twins: Heritability and genetic overlap with psychological variables and stress-system genes. Scientific Reports, 7(1), p. 15351. Nature Publishing Group 10.1038/s41598-017-11852-3

Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual

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http://urn.fi/urn:nbn:fi-fe2019062822296