Comparison of clinical selection-based genetic testing with phenotype-agnostic extensive germline sequencing to diagnose genetic predisposition in children with cancer: a prospective diagnostic study.

Autor: Bakhuizen JJ; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., van Dijk F; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Koudijs MJ; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Bladergroen RS; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Bon SBB; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Hopman SMJ; Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Kester LA; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Kranendonk MEG; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Loeffen JLC; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Smetsers SE; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Sonneveld E; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Tachdjian M; Research Institute of the McGill University Health Centre, Child Health and Human Development Program, Montreal, QC, Canada., de Vos-Kerkhof E; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., Goudie C; Research Institute of the McGill University Health Centre, Child Health and Human Development Program, Montreal, QC, Canada; Department of Pediatrics, Division of Hematology-Oncology, McGill University Health Centre, Montreal, QC, Canada., Merks JHM; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Division of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Kuiper RP; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Jongmans MCJ; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands; Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. Electronic address: m.c.j.jongmans-3@umcutrecht.nl.

Publikováno v: The Lancet. Child & adolescent health [Lancet Child Adolesc Health] 2024 Oct; Vol. 8 (10), pp. 751-761. Date of Electronic Publication: 2024 Aug 16.

Experiences of pediatric cancer patients (age 12-18 years) with extensive germline sequencing for cancer predisposition: a qualitative study.

Autor: Bon SBB; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. s.b.b.bon@prinsesmaximacentrum.nl., Wouters RHP; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Psychiatry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Bakhuizen JJ; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands., Jongmans MCJ; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.; Division of Child Health, UMCU-Wilhelmina's Children's Hospital, Utrecht, The Netherlands., van den Heuvel-Eibrink MM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Division of Child Health, UMCU-Wilhelmina's Children's Hospital, Utrecht, The Netherlands., Grootenhuis MA; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Division of Child Health, UMCU-Wilhelmina's Children's Hospital, Utrecht, The Netherlands.

Publikováno v: European journal of human genetics : EJHG [Eur J Hum Genet] 2024 May; Vol. 32 (5), pp. 567-575. Date of Electronic Publication: 2024 Feb 27.

No Pathogenic DICER1 Gene Variants in a Cohort Study of 28 Children With Congenital Pulmonary Airway Malformation.

Autor: Bakhuizen JJ; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Department of Genetics, University Medical Center Utrecht, Utrecht, the Netherlands., Postema FAM; Department of Pediatrics, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands., van Rijn RR; Department of Radiology and Nuclear Medicine, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands., van Schuppen J; Department of Radiology and Nuclear Medicine, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands., Duijkers FAM; Department of Clinical Genetics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands., van Noesel CJM; Department of Pathology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands., Hennekam RC; Department of Pediatrics, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands., Jongmans MCJ; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Department of Genetics, University Medical Center Utrecht, Utrecht, the Netherlands., Savci-Heijink CD; Department of Pathology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands., Smetsers SE; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Terheggen-Lagro SWJ; Department of Pediatric Pulmonology and Allergy, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands., Hopman SMJ; Department of Genetics, University Medical Center Utrecht, Utrecht, the Netherlands., Oomen MWN; Department of Pediatric Surgery, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands., Merks JHM; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Division of Imaging and Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address: J.H.M.Merks@prinsesmaximacentrum.nl.

Publikováno v: Journal of pediatric surgery [J Pediatr Surg] 2024 Mar; Vol. 59 (3), pp. 459-463. Date of Electronic Publication: 2023 Oct 21.

Implementation of paediatric precision oncology into clinical practice: The Individualized Therapies for Children with cancer program 'iTHER'.

Autor: Langenberg KPS; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands. Electronic address: k.p.s.langenberg@prinsesmaximacentrum.nl., Meister MT; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Oncode Institute, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Bakhuizen JJ; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Boer JM; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., van Eijkelenburg NKA; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Hulleman E; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Ilan U; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Looze EJ; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Dierselhuis MP; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., van der Lugt J; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Breunis W; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Universitäts-Kinderspital Zürich, Steinwiesstrasse 75, 8032 Zürich, Switzerland., Schild LG; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Ober K; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., van Hooff SR; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Scheijde-Vermeulen MA; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Genetics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Hiemcke-Jiwa LS; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Genetics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Flucke UE; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Genetics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Kranendonk MEG; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Genetics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Wesseling P; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Genetics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Sonneveld E; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Punt S; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Boltjes A; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., van Dijk F; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Verwiel ETP; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Volckmann R; Department of Oncogenomics, Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands., Hehir-Kwa JY; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Kester LA; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Koudijs MMJ; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Waanders E; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Holstege FCP; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Center for Molecular Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Vormoor HJ; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Universitäts-Kinderspital Zürich, Steinwiesstrasse 75, 8032 Zürich, Switzerland; Newcastle University, Newcastle Upon Tyne, NE1 7RU, UK., Hoving EW; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., van Noesel MM; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Division Imaging & Cancer, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Pieters R; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Kool M; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Stumpf M; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Blattner-Johnson M; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Balasubramanian GP; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Van Tilburg CM; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Department of Pediatric Hematology and Oncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Jones BC; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Department of Pediatric Hematology and Oncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Jones DTW; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Witt O; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Department of Pediatric Hematology and Oncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Department of Pediatric Hematology and Oncology, Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany., Jongmans MCJ; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Kuiper RP; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., de Krijger RR; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Genetics, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Wijnen MHW; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., den Boer ML; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Zwaan CM; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Kemmeren P; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Center for Molecular Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands., Koster J; Department of Oncogenomics, Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands., Tops BBJ; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Goemans BF; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands., Molenaar JJ; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands; Department of Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, the Netherlands.

Publikováno v: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2022 Nov; Vol. 175, pp. 311-325. Date of Electronic Publication: 2022 Sep 29.

Genetic counselling of young women with breast cancer for Li-Fraumeni syndrome: a nationwide survey on the experiences and attitudes of genetics professionals.

Autor: Bakhuizen JJ; Department of Genetics, University Medical Center Utrecht, PO Box 85090, 3508 AB, Utrecht, The Netherlands. j.j.bakhuizen-2@umcutrecht.nl., Velthuizen ME; Department of Genetics, University Medical Center Utrecht, PO Box 85090, 3508 AB, Utrecht, The Netherlands., Stehouwer S; Department of Genetics, University Medical Center Utrecht, PO Box 85090, 3508 AB, Utrecht, The Netherlands., Bleiker EM; Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, The Netherlands.; Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Ausems MG; Department of Genetics, University Medical Center Utrecht, PO Box 85090, 3508 AB, Utrecht, The Netherlands.

Publikováno v: Familial cancer [Fam Cancer] 2019 Apr; Vol. 18 (2), pp. 231-239.