Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides

Autor: Dysko, A, Baker, YR, McClorey, G, Wood, MJA, Fenner, S, Williams, G, El-Sagheer, A, Brown, T

Publikováno v: RSC Chemical Biology. 3:765-772

Oligonucleotides are rapidly emerging as powerful therapeutics for hard to treat diseases. Short single-stranded oligonucleotides can base pair with target RNA and alter gene expression, providing an attractive therapeutic approach at the genetic lev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816b15556eb0a0b33dec6318baf8e24e
https://doi.org/10.1039/d2cb00100d

Preparation and characterization of manganese, cobalt and zinc DNA nanoflowers with tuneable morphology, DNA content and size

Autor: Baker, YR, Chen, J, Brown, J, El-Sagheer, AH, Wiseman, P, Johnson, E, Goddard, P, Brown, T

Publikováno v: Nucleic Acids Research

Recently reported DNA nanoflowers are an interesting class of organic-inorganic hybrid materials which are prepared using DNA polymerases. DNA nanoflowers combine the high surface area and scaffolding of inorganic Mg2P2O7 nanocrystals with the target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4c48e470780db09d4dd3122b6b975ac7
http://ora.ox.ac.uk/objects/uuid:

An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.

Autor: Baker YR; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Thorpe C; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Chen J; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Poller LM; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Cox L; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Kumar P; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Lim WF; Department of Paediatrics, University of Oxford, LGC building, South Parks Road, Oxford, OX1 3QX, UK., Lie L; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., McClorey G; Department of Paediatrics, University of Oxford, LGC building, South Parks Road, Oxford, OX1 3QX, UK., Epple S; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Singleton D; ATDBio Ltd, School of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, UK., McDonough MA; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Hardwick JS; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Christensen KE; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Wood MJA; Department of Paediatrics, University of Oxford, LGC building, South Parks Road, Oxford, OX1 3QX, UK., Hall JP; Department of Pharmacy, Chemistry and Pharmacy Building, University of Reading, Whiteknights, Reading, RG6 6AD, UK., El-Sagheer AH; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.; Department of Science and Mathematics, Suez University, Faculty of Petroleum and Mining Engineering, Suez, 43721, Egypt., Brown T; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK. tom.brown@chem.ox.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2022 Jul 12; Vol. 13 (1), pp. 4036. Date of Electronic Publication: 2022 Jul 12.

A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility.

Autor: Epple S; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K., Modi A; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K., Baker YR; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K., Wȩgrzyn E; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K., Traoré D; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K., Wanat P; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K., Tyburn AES; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K., Shivalingam A; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K., Taemaitree L; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K., El-Sagheer AH; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.; Chemistry Branch, Department of Science and Mathematics, Faculty of Petroleum and Mining Engineering, Suez University, Suez 43721, Egypt., Brown T; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2021 Oct 06; Vol. 143 (39), pp. 16293-16301. Date of Electronic Publication: 2021 Sep 21.

Consecutive 5'- and 3'-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response.

Autor: Epple S; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK. tom.brown@chem.ox.ac.uk., Thorpe C; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK. tom.brown@chem.ox.ac.uk., Baker YR; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK. tom.brown@chem.ox.ac.uk., El-Sagheer AH; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK. tom.brown@chem.ox.ac.uk and Chemistry Branch, Department of Science and Mathematics, Faculty of Petroleum and Mining Engineering, Suez University, Suez 43721, Egypt., Brown T; Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, UK. tom.brown@chem.ox.ac.uk.

Publikováno v: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 May 21; Vol. 56 (41), pp. 5496-5499.