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pro vyhledávání: '"Baker, Michael E."'
Due to alternative splicing in an ancestral DNA-binding domain (DBD) of the mineralocorticoid receptor (MR), humans contain two almost identical MR transcripts with either 984 amino acids (MR-984) or 988 amino acids (MR-988), in which their DBDs diff
Externí odkaz:
http://arxiv.org/abs/2405.10432
Five distinct full-length mineralocorticoid receptor (MR) genes have been identified in humans. These human MRs can be distinguished by the presence or absence of an in-frame insertion of 12 base pairs coding for Lys, Cys, Ser, Trp (KCSW) in their DN
Externí odkaz:
http://arxiv.org/abs/2312.05396
Atlantic sea lamprey contains two corticoid receptors (CRs), CR1 and CR2, that are identical except for a four amino acid insert (Thr-Arg-Gln-Gly) in the CR1 DNA-binding domain (DBD). Steroids are stronger transcriptional activators of CR2 than of CR
Externí odkaz:
http://arxiv.org/abs/2302.13162
Autor:
Katsu, Yoshinao, Lin, Xiaozhi, Ji, Ruigeng, Chen, Ze, Kamisaka, Yui, Bamba, Koto, Baker, Michael E.
Lampreys are jawless fish that evolved about 550 million years ago at the base of the vertebrate line. Modern lampreys contain a corticoid receptor (CR), the common ancestor of the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), whi
Externí odkaz:
http://arxiv.org/abs/2210.04111
Autor:
Baker, Michael E.
There is much concern about disruption of endocrine physiology regulated by steroid hormones in humans, other terrestrial vertebrates and fish by industrial chemicals, such as bisphenol A, and pesticides, such as DDT. These endocrine-disrupting chemi
Externí odkaz:
http://arxiv.org/abs/2111.10661
Aldosterone, the main physiological mineralocorticoid in humans and other terrestrial vertebrates, first appears in lungfish, which are lobe-finned fish that are forerunners of terrestrial vertebrates. Aldosterone activation of the MR regulates inter
Externí odkaz:
http://arxiv.org/abs/2106.14114
Autor:
Lin, Xiaozhi, Takagi, Wataru, Hyodo, Susumu, Ijiri, Shigeho, Katsu, Yoshinao, Baker, Michael E.
We investigated progestin and corticosteroid activation of the progesterone receptor (PR) from elephant shark (Callorhinchus milii), a cartilaginous fish belonging to the oldest group of jawed vertebrates. Comparison with human PR experiments provide
Externí odkaz:
http://arxiv.org/abs/2101.09626
Autor:
Baker, Michael E., Katsu, Yoshinao
The progesterone receptor (PR) mediates progesterone regulation of female reproductive physiology, as well as gene transcription in non-reproductive tissues, such as brain, bone, lung and vasculature, in both women and men. An unusual property of pro
Externí odkaz:
http://arxiv.org/abs/2001.07822
Autor:
Katsu, Yoshinao, Shariful, Islam MD, Lin, Xiaozhi, Takagi, Wataru, Urushitani, Hiroshi, Kohno, Satomi, Hyodo, Susumu, Baker, Michael E.
Cortisol, corticosterone and aldosterone activate full-length glucocorticoid receptor (GR) from elephant shark, a cartilaginous fish belonging to the oldest group of jawed vertebrates. Activation by aldosterone a mineralocorticoid, indicates partial
Externí odkaz:
http://arxiv.org/abs/1911.03517
Autor:
Baker, Michael E.
Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago. Results from sequence analyses of genomes from bacteria, yeast
Externí odkaz:
http://arxiv.org/abs/1901.09944