DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response.

Autor: Yulyaningsih E; Denali Therapeutics, South San Francisco, United States., Suh JH; Denali Therapeutics, South San Francisco, United States., Fanok M; Denali Therapeutics, South San Francisco, United States., Chau R; Denali Therapeutics, South San Francisco, United States., Solanoy H; Denali Therapeutics, South San Francisco, United States., Takahashi R; Denali Therapeutics, South San Francisco, United States., Bakardjiev AI; Denali Therapeutics, South San Francisco, United States., Becerra I; Denali Therapeutics, South San Francisco, United States., Benitez NB; Denali Therapeutics, South San Francisco, United States., Chiu CL; Denali Therapeutics, South San Francisco, United States., Davis SS; Denali Therapeutics, South San Francisco, United States., Dowdle WE; Denali Therapeutics, South San Francisco, United States., Earr T; Denali Therapeutics, South San Francisco, United States., Estrada AA; Denali Therapeutics, South San Francisco, United States., Gill A; Denali Therapeutics, South San Francisco, United States., Ha C; Denali Therapeutics, South San Francisco, United States., Haddick PCG; Denali Therapeutics, South San Francisco, United States., Henne KR; Denali Therapeutics, South San Francisco, United States., Larhammar M; Denali Therapeutics, South San Francisco, United States., Leung AW; Denali Therapeutics, South San Francisco, United States., Maciuca R; Denali Therapeutics, South San Francisco, United States., Memarzadeh B; Denali Therapeutics, South San Francisco, United States., Nguyen HN; Denali Therapeutics, South San Francisco, United States., Nugent AA; Denali Therapeutics, South San Francisco, United States., Osipov M; Denali Therapeutics, South San Francisco, United States., Ran Y; Denali Therapeutics, South San Francisco, United States., Rebadulla K; Denali Therapeutics, South San Francisco, United States., Roche E; Denali Therapeutics, South San Francisco, United States., Sandmann T; Denali Therapeutics, South San Francisco, United States., Wang J; Denali Therapeutics, South San Francisco, United States., Lewcock JW; Denali Therapeutics, South San Francisco, United States., Scearce-Levie K; Denali Therapeutics, South San Francisco, United States., Kane LA; Denali Therapeutics, South San Francisco, United States., Sanchez PE; Denali Therapeutics, South San Francisco, United States.

Publikováno v: ELife [Elife] 2024 Sep 17; Vol. 12. Date of Electronic Publication: 2024 Sep 17.

In Vivo Virulence Characterization of Pregnancy-Associated Listeria monocytogenes Infections

Autor: Robbins, Bakardjiev Ai, Lowe D, Morrison Ha

Publikováno v: Infection and Immunity

Listeria monocytogenes is a foodborne pathogen that infects the placenta and can cause pregnancy complications. Listeriosis usually occurs as a sporadic infection, but large outbreaks are also reported.
Listeria monocytogenes is a foodborne path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b012559c3663126074440da02749d5
https://doi.org/10.1128/iai.00397-18

First trimester typhoid Fever with vertical transmission of salmonella typhi, an intracellular organism

Autor: Bakardjiev, Anna, Vigliani, MB, Bakardjiev, AI

Publikováno v: Bakardjiev, Anna; Vigliani, MB; & Bakardjiev, AI. (2013). First trimester typhoid Fever with vertical transmission of salmonella typhi, an intracellular organism.. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/52z5v2s6

We report a case in which placental abruption occurred at 16 weeks following first trimester diagnosis and treatment for typhoid fever. Unexpectedly Salmonella enterica serovar Typhi (S. Typhi) was found in fetal tissues at autopsy. Using information

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::3d1d32128d781ddaf7490f4555c2169c
http://www.escholarship.org/uc/item/52z5v2s6

Placental Syncytium Forms a Biophysical Barrier against Pathogen Invasion

Autor: Maltepe, Emin, Bakardjiev, Anna, Zeldovich, VB, Clausen, CH, Bradford, E, Fletcher, DA, Robbins, JR, Bakardjiev, AI

Publikováno v: Maltepe, Emin; Bakardjiev, Anna; Zeldovich, VB; Clausen, CH; Bradford, E; Fletcher, DA; et al.(2013). Placental Syncytium Forms a Biophysical Barrier against Pathogen Invasion. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/53x7n02r

Fetal syncytiotrophoblasts form a unique fused multinuclear surface that is bathed in maternal blood, and constitutes the main interface between fetus and mother. Syncytiotrophoblasts are exposed to pathogens circulating in maternal blood, and appear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::e47fb2d755ec889a1bad28d5167d3497
http://www.escholarship.org/uc/item/53x7n02r

Listeria monocytogenes InlP interacts with afadin and facilitates basement membrane crossing.

Autor: Faralla C; Benioff Children's Hospital, University of California, San Francisco, San Francisco, California, United States of America.; Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, San Francisco, California, United States of America., Bastounis EE; Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America., Ortega FE; Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America., Light SH; Center for Structural Genomics of Infectious Diseases and Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America., Rizzuto G; Benioff Children's Hospital, University of California, San Francisco, San Francisco, California, United States of America.; Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, San Francisco, California, United States of America.; Department of Pathology, University of California, San Francisco, San Francisco, California, United States of America., Gao L; Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America., Marciano DK; Department of Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America., Nocadello S; Center for Structural Genomics of Infectious Diseases and Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America., Anderson WF; Center for Structural Genomics of Infectious Diseases and Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America., Robbins JR; Department of Biology, Xavier University, Cincinnati, Ohio, United States of America., Theriot JA; Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America.; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America.; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America., Bakardjiev AI; Benioff Children's Hospital, University of California, San Francisco, San Francisco, California, United States of America.; Program in Microbial Pathogenesis and Host Defense, University of California, San Francisco, San Francisco, California, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2018 May 30; Vol. 14 (5), pp. e1007094. Date of Electronic Publication: 2018 May 30 (Print Publication: 2018).