Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function

Autor: Laustsen, A, Bak, RO, Krapp, C, Kjær, L, Egedahl, JH, Petersen, CC, Pillai, S, Tang, HQ, Uldbjerg, N, Porteus, M, Roan, NR, Nyegaard, M, Denton, PW, Jakobsen, MR

Publikováno v: Nature communications, vol 9, iss 1
Laustsen, A; Bak, RO; Krapp, C; Kjær, L; Egedahl, JH; Petersen, CC; et al.(2018). Interferon priming is essential for human CD34+ cell-derived plasmacytoid dendritic cell maturation and function.. Nature communications, 9(1), 3525. doi: 10.1038/s41467-018-05816-y. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3979k69n

Plasmacytoid dendritic cells (pDC) are essential for immune competence. Here we show that pDC precursor differentiated from human CD34+ hematopoietic stem and progenitor cells (HSPC) has low surface expression of pDC markers, and has limited inductio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::eda1babf21c913904b72d574a54963df
https://escholarship.org/uc/item/3979k69n

Orthogonal transcriptional modulation and gene editing using multiple CRISPR/Cas systems.

Autor: Broksø AD; Department of Biomedicine, Aarhus University, Aarhus C., Denmark., Bendixen L; Department of Biomedicine, Aarhus University, Aarhus C., Denmark., Fammé S; Department of Biomedicine, Aarhus University, Aarhus C., Denmark., Mikkelsen K; Department of Biomedicine, Aarhus University, Aarhus C., Denmark., Jensen TI; Department of Biomedicine, Aarhus University, Aarhus C., Denmark., Bak RO; Department of Biomedicine, Aarhus University, Aarhus C., Denmark. Electronic address: bak@biomed.au.dk.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2024 Nov 19. Date of Electronic Publication: 2024 Nov 19.

SAM68 directs STING signaling to apoptosis in macrophages.

Autor: van der Horst D; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Kurmasheva N; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Marqvorsen MHS; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Assil S; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Rahimic AHF; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Kollmann CF; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Silva da Costa L; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Wu Q; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Zhao J; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Cesari E; GSTEP-Organoids Core Facility, IRCCS Fondazione Policlinico Agostino Gemelli, 00168, Rome, Italy., Iversen MB; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Ren F; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Jensen TI; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Narita R; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Schack VR; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Zhang BC; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Bak RO; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Sette C; GSTEP-Organoids Core Facility, IRCCS Fondazione Policlinico Agostino Gemelli, 00168, Rome, Italy.; Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Hearth, 00168, Rome, Italy., Fenton RA; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Mikkelsen JG; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark., Paludan SR; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark. srp@biomed.au.dk., Olagnier D; Department of Biomedicine, Aarhus University, Høegh Guldbergsgade 10, 8000, Aarhus C, Denmark. olagnier@biomed.au.dk.

Publikováno v: Communications biology [Commun Biol] 2024 Mar 07; Vol. 7 (1), pp. 283. Date of Electronic Publication: 2024 Mar 07.

CRISPR activation to characterize splice-altering variants in easily accessible cells.

Autor: Terkelsen T; Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark. Electronic address: thorkild.terkelsen@clin.au.dk., Mikkelsen NS; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Bak EN; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Vad-Nielsen J; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Blechingberg J; Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark., Weiss S; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Drue SO; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Andersen H; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark., Andresen BS; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Bak RO; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Jensen UB; Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark. Electronic address: uffejens@rm.dk.

Publikováno v: American journal of human genetics [Am J Hum Genet] 2024 Feb 01; Vol. 111 (2), pp. 309-322. Date of Electronic Publication: 2024 Jan 24.

Progress and harmonization of gene editing to treat human diseases: Proceeding of COST Action CA21113 GenE-HumDi.

Autor: Cavazza A; Infection, Immunity and Inflammation Research and Teaching Department, Great Ormond Street Institute of Child Health, University College London, WC1N 1EH London, UK., Hendel A; Institute of Nanotechnology and Advanced Materials, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel., Bak RO; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark., Rio P; Hematopoietic Innovative Therapies Division, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIEMAT/CIBERER), 28040 Madrid, Spain.; Advanced Therapies Unit, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD, UAM), 28040 Madrid, Spain., Güell M; Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.; Integra Therapeutics S.L., Barcelona, Spain., Lainšček D; Department of Synthetic Biology and Immunology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia., Arechavala-Gomeza V; Nucleic Acid Therapeutics for Rare Disorders (NAT-RD), Biobizkaia Health Research Institute, Barakaldo, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain., Peng L; Aix Marseille University, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, Equipe Labellisée Ligue Contre le Cancer, 13288 Marseille, France., Hapil FZ; Department of Medical Biology and Genetics, Faculty of Medicine, Akdeniz University, Antalya, Turkey., Harvey J; Institute of Ophthalmology, University College London, London, UK., Ortega FG; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, Avenida de la Ilustración 114, 18016 Granada, Spain.; IBS Granada, Institute of Biomedical Research, Avenida de Madrid 15, 18012 Granada, Spain., Gonzalez-Martinez C; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, Avenida de la Ilustración 114, 18016 Granada, Spain.; IBS Granada, Institute of Biomedical Research, Avenida de Madrid 15, 18012 Granada, Spain., Lederer CW; Department of Molecular Genetics Thalassaemia, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus., Mikkelsen K; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark., Gasiunas G; CasZyme, 10224 Vilnius, Lithuania., Kalter N; Institute of Nanotechnology and Advanced Materials, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel., Gonçalves MAFV; Department of Cell and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, the Netherlands., Petersen J; Steno Diabetes Center Aarhus, Aarhus University Hospital, 8200 Aarhus N, Denmark., Garanto A; Department of Pediatrics and Department of Human Genetics, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, the Netherlands., Montoliu L; Department of Molecular and Cellular Biology, National Centre for Biotechnology (CNB-CSIC) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER-ISCIII), Madrid, Spain., Maresca M; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden., Seemann SE; Center for Non-coding RNA in Technology and Health, Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark., Gorodkin J; Center for Non-coding RNA in Technology and Health, Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark., Mazini L; Laboratory of Genetic Engineering, Technologic, Medical and Academic Park (TMAP), Marrakech, Morocco., Sanchez R; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain.; Department of Medicinal & Organic Chemistry and Excellence Research Unit of 'Chemistry Applied to Biomedicine and the Environment,' Faculty of Pharmacy, University of Granada, Campus de Cartuja s/n, Granada, Spain.; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Universidad de Granada, Granada, Spain., Rodriguez-Madoz JR; Cancer Center Clinica Universidad de Navarra (CCUN), Pamplona, Spain.; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.; Centro de Investigación Biomédica en Red de Cancer (CIBERONC), Madrid, Spain., Maldonado-Pérez N; Steno Diabetes Center Aarhus, Aarhus University Hospital, 8200 Aarhus N, Denmark., Laura T; DNA & RNA Medicine Division, Center for Applied Medical Research (CIMA) Universidad de Navarra, 31008 Pamplona, Spain., Schmueck-Henneresse M; Berlin Institute for Health (BIH) at Charité - Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Charitéplatz 1, 10117 Berlin, Germany., Maccalli C; Laboratory of Immune Biological Therapy, Research Branch, Sidra Medicine, PO Box 26999, Doha, Qatar., Grünewald J; Department of Medicine, Cardiology, Angiology, Pneumology, Klinikum rechts der Isar, Technical University of Munich, TUM School of Medicine and Health, TranslaTUM, MIBE, Munich, Germany.; Center for Organoid Systems, Munich, Germany., Carmona G; Red Andaluza de diseño y traslación de Terapias Avanzadas-RAdytTA, Fundación Pública Andaluza Progreso y Salud-FPS, Sevilla, España., Kachamakova-Trojanowska N; Malopolska Centre of Biotechnology, Jagiellonian University, 30-387 Krakow, Poland., Miccio A; Imagine Institute, Laboratory of Chromatin and Gene Regulation During Development, Université de Paris Cité, INSERM UMR 1163, 75015 Paris, France., Martin F; Bioquímica y Biología Molecular III e Immunology Department, Facultad de Medicina, Universidad de Granada and Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), PTS, Av. de la Ilustración 114, 18016 Granada, Spain., Turchiano G; Infection, Immunity and Inflammation Research and Teaching Department, Great Ormond Street Institute of Child Health, University College London, WC1N 1EH London, UK., Cathomen T; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, Freiburg, Germany.; Medical Faculty, University of Freiburg, 79106 Freiburg, Germany., Luo Y; Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.; Steno Diabetes Center Aarhus, Aarhus University Hospital, 8200 Aarhus N, Denmark., Tsai SQ; Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Benabdellah K; Department of Genomic Medicine, Pfizer-University of Granada-Andalusian Regional Government Centre for Genomics and Oncological Research (GENYO), PTS, Av. de la Ilustración 114, 18016 Granada, Spain.

Publikováno v: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2023 Oct 29; Vol. 34, pp. 102066. Date of Electronic Publication: 2023 Oct 29 (Print Publication: 2023).