Vpliv genov povezanih z amiotrofično lateralno sklerozo na biokemijske lastnosti in celično lokalizacijo proteina TDP-43

Autor: Bajc Česnik, Ana

Uvod: Amiotrofična lateralna skleroza (ALS) je smrtonosna napredujoča nevrodegenerativna bolezen, za katero so značilni citoplazemski skupki proteinov v prizadetih nevronih. Glavna komponenta teh inkluzij je ubikvitiniran, fosforiliran in cepljen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3505::f43da0c572aa1b8b1efd16c3efae73f8
https://hdl.handle.net/20.500.12556/RUL-122360

The Impact of ALS-Associated Genes hnRNPA1, MATR3, VCP and UBQLN2 on the Severity of TDP-43 Aggregation.

Autor: Bajc Česnik, Ana^1,2 (AUTHOR) ana.bajc.cesnik@ijs.si, Motaln, Helena¹ (AUTHOR) helena.motaln@ijs.si, Rogelj, Boris^1,3,4 (AUTHOR) boris.rogelj@ijs.si

Publikováno v: Cells (2073-4409). Aug2020, Vol. 9 Issue 8, p1791. 1p.

Nuclear RNA foci from C9ORF72 expansion mutation form paraspeckle-like bodies.

Autor: Bajc Česnik A; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia.; Graduate School of Biomedicine, Faculty of Medicine, University of Ljubljana, Ljubljana 1000, Slovenia., Darovic S; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia.; Biomedical Research Institute BRIS, Ljubljana 1000, Slovenia., Prpar Mihevc S; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia., Štalekar M; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia.; Biomedical Research Institute BRIS, Ljubljana 1000, Slovenia., Malnar M; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia.; Graduate School of Biomedicine, Faculty of Medicine, University of Ljubljana, Ljubljana 1000, Slovenia., Motaln H; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia., Lee YB; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, King's College London, London SE5 9RT, UK., Mazej J; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia.; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana 1000, Slovenia., Pohleven J; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia., Grosch M; Helmholtz Center Munich, Institute of Stem Cell Research, German Research Center for Environmental Health, Neuherberg 85764, Germany., Modic M; Helmholtz Center Munich, Institute of Stem Cell Research, German Research Center for Environmental Health, Neuherberg 85764, Germany., Fonovič M; Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana 1000, Slovenia., Turk B; Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana 1000, Slovenia., Drukker M; Helmholtz Center Munich, Institute of Stem Cell Research, German Research Center for Environmental Health, Neuherberg 85764, Germany., Shaw CE; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, King's College London, London SE5 9RT, UK., Rogelj B; Department of Biotechnology, Jozef Stefan Institute, Ljubljana 1000, Slovenia boris.rogelj@ijs.si.; Biomedical Research Institute BRIS, Ljubljana 1000, Slovenia.; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana 1000, Slovenia.

Publikováno v: Journal of cell science [J Cell Sci] 2019 Mar 07; Vol. 132 (5). Date of Electronic Publication: 2019 Mar 07.