A CLN6-CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer

Autor: Bajaj, Lakshya, Sharma, Jaiprakash, di Ronza, Alberto, Zhang, Pengcheng, Eblimit, Aiden, Pal, Rituraj, Roman, Dany, Collette, John R, Booth, Clarissa, Chang, Kevin T, Sifers, Richard N, Jung, Sung Y, Weimer, Jill M, Chen, Rui, Schekman, Randy W, Sardiello, Marco

Publikováno v: The Journal of clinical investigation, vol 130, iss 8

Lysosomal enzymes are synthesized in the endoplasmic reticulum (ER) and transferred to the Golgi complex by interaction with the Batten disease protein CLN8 (ceroid lipofuscinosis, neuronal, 8). Here we investigated the relationship of this pathway w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::356d2755207edb33c7d57053a07b4760
https://escholarship.org/uc/item/4k12r75x

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

A CLN6-CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer.

Autor: Bajaj L; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas, USA., Sharma J; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas, USA., di Ronza A; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas, USA., Zhang P; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA., Eblimit A; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA., Pal R; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas, USA., Roman D; Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA., Collette JR; Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA., Booth C; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, South Dakota, USA.; Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota, USA., Chang KT; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas, USA., Sifers RN; Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA., Jung SY; Department of Biochemistry and Molecular Biology., Weimer JM; Pediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, South Dakota, USA.; Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota, USA., Chen R; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.; Human Genome Sequencing Center, and.; Department of Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, Texas, USA., Schekman RW; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, California, USA., Sardiello M; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.; Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, Texas, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2020 Aug 03; Vol. 130 (8), pp. 4118-4132.