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Development of Receptors for Aqueous Carbohydrate Recognition

Autor: Baj, Vanessa

Publikováno v: Baj, V 2019, Development of Receptors for Aqueous Carbohydrate Recognition . Technical University of Denmark, Kgs. Lyngby .

Sialic acids are a diverse family of carbohydrates widely distributed in human tissues and specifically present in both N- and O-linked glycans, where they constitute the terminal residue of the oligosaccharides on glycoproteins. Sialylation is impor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1202::8bb13e4ee58f4520e4cfc312a756aeba
https://orbit.dtu.dk/en/publications/b96ed304-3265-4da5-8861-4a5052ff2815

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Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors

Autor: Luciana Marinelli, Preet Lal, Emiliano Biasini, Chiara Zucal, Alessandro Provenzani, Vito Giuseppe D'Agostino, Pierfausto Seneci, Vanessa Baj, Natthakan Thongon, Saioa R. Elezgarai, Danilo Di Maio, Linda Cerofolini, Claudio Luchinat, Leonardo Manzoni, Ettore Novellino, Marta Brambilla, Marco Fragai, Marco Miceli, Isabelle Bonomo

Publikováno v: Journal of medicinal chemistry 61 (2018): 1483–1498. doi:10.1021/acs.jmedchem.7b01176
info:cnr-pdr/source/autori:Manzoni L.; Zucal C.; Maio D.D.; D'Agostino V.G.; Thongon N.; Bonomo I.; Lal P.; Miceli M.; Baj V.; Brambilla M.; Cerofolini L.; Elezgarai S.; Biasini E.; Luchinat C.; Novellino E.; Fragai M.; Marinelli L.; Provenzani A.; Seneci P./titolo:Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors/doi:10.1021%2Facs.jmedchem.7b01176/rivista:Journal of medicinal chemistry/anno:2018/pagina_da:1483/pagina_a:1498/intervallo_pagine:1483–1498/volume:61

The human antigen R (HuR) is an RNA-binding protein known to modulate the expression of target mRNA coding for proteins involved in inflammation, tumorigenesis, and stress responses and is a valuable drug target. We previously found that dihydrotansh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909b50e95821430ff362c6edb7f96dee
https://pubmed.ncbi.nlm.nih.gov/29313684