Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Baisong, Lu"'
Publikováno v:
Genes and Diseases, Vol 11, Iss 6, Pp 101117- (2024)
Renal fibrosis is a complex and multifactorial process that involves inflammation, cell proliferation, collagen, and fibronectin deposition in the kidney, ultimately leading to chronic kidney disease and even end-stage renal disease. The main goal of
Externí odkaz:
https://doaj.org/article/f72e016b01684ae188798e3bdf221540
Publikováno v:
Discover Oncology, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Purpose Chordoma is a rare and aggressive bone cancer driven by the developmental transcription factor brachyury. Efforts to target brachyury are hampered by the absence of ligand-accessible small-molecule binding pockets. Genome editing wit
Externí odkaz:
https://doaj.org/article/b8597b7068754efca3547b29d2f1a92e
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 149-166 (2022)
Type 1 Dent disease is caused by changes in chloride voltage-gated channel 5 (CLCN5) gene on chromosome X, which causes the lack or dysfunction of chloride channel ClC-5. Affected subjects show proteinuria and hypercalciuria, and eventually develop e
Externí odkaz:
https://doaj.org/article/238a45230cd44fdcb6a497e050018e35
Autor:
Duràn, Mònica, Ariceta, Gema, Semidey, Maria E., Castells-Esteve, Carla, Casal-Pardo, Andrea, Baisong Lu, Meseguer, Anna, Cantero-Recasens, Gerard
Publikováno v:
Life Science Alliance; Jul2024, Vol. 7 Issue 7, p1-17, 17p
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 5, Pp n/a-n/a (2021)
Abstract Transient delivery of CRISPR‐based genome editing effectors is important to reduce off‐target effects and immune responses. Recently extracellular vesicles (EVs) have been explored for Cas9 ribonucleoprotein (RNP) delivery. However, lack
Externí odkaz:
https://doaj.org/article/79d9857902784c08ad6f80f58cdf9eb8
Autor:
Pin Lyu, Kyung Whan Yoo, Manish Kumar Yadav, Anthony Atala, Annemieke Aartsma-Rus, Maaike van Putten, Dongsheng Duan, Baisong Lu
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239468 (2020)
Most Duchenne muscular dystrophy (DMD) cases are caused by deletions or duplications of one or more exons that disrupt the reading frame of DMD mRNA. Restoring the reading frame allows the production of partially functional dystrophin proteins, and r
Externí odkaz:
https://doaj.org/article/cf35423d69684f1faff13463cecab734
Autor:
Nalinda B. Wasala, Emily D. Million, Thais B. Watkins, Lakmini P. Wasala, Jin Han, Yongping Yue, Baisong Lu, Shi-jie Chen, Chady H. Hakim, Dongsheng Duan
Publikováno v:
Hum Gene Ther
Adeno-associated virus (AAV)-mediated clustered regularly interspaced short palindromic repeats (CRISPR) editing holds promise to restore missing dystrophin in Duchenne muscular dystrophy (DMD). Intramuscular coinjection of CRISPR-associated protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20bae538125f53cedcdc205fb649074e
https://doi.org/10.1089/hum.2021.130
https://doi.org/10.1089/hum.2021.130
Publikováno v:
Nucleic Acids Research. 50:3944-3957
Most insertions or deletions generated by CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) endonucleases are short (500 bp) can be observed. The possibility of generating long on-target DNA deletions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248012626ecc82cf7a47e33bf236db27
https://doi.org/10.1093/nar/gkac186
https://doi.org/10.1093/nar/gkac186
Publikováno v:
Life, Vol 10, Iss 12, p 366 (2020)
The discovery of designer nucleases has made genome editing much more efficient than before. The designer nucleases have been widely used for mechanistic studies, animal model generation and gene therapy development. However, potential off-targets an
Externí odkaz:
https://doaj.org/article/2184e2db55b7467d915591fd8d185c7e
Autor:
Zuyan Lu, Xiangwan Miao, Qianqian Song, Huifen Ding, Rajan, Shiny Amala Priya, Skardal, Aleksander, Votanopoulos, Konstantinos I., Kerong Dai, Weixin Zhao, Baisong Lu, Atala, Anthony
Publikováno v:
Theranostics; 2023, Vol. 13 Issue 14, p4905-4918, 14p