Bone marrow mesenchymal stromal cell-derived extracellular matrix displays altered glycosaminoglycan structure and impaired functionality in Myelodysplastic Syndromes

Autor: Bains, Amanpreet Kaur, Behrens Wu, Lena, Rivière, Jennifer, Rother, Sandra, Magno, Valentina, Friedrichs, Jens, Werner, Carsten, Bornhäuser, Martin, Götze, Katharina S., Cross, Michael, Platzbecker, Uwe, Wobus, Manja

Myelodysplastic syndromes (MDS) comprise a heterogeneous group of hematologic malignancies characterized by clonal hematopoiesis, one or more cytopenias such as anemia, neutropenia, or thrombocytopenia, abnormal cellular maturation, and a high risk o

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Bone marrow mesenchymal stromal cell-derived extracellular matrix displays altered glycosaminoglycan structure and impaired functionality in Myelodysplastic Syndromes.

Autor: Bains AK; Medical Department I, Haematology and Cell Therapy, University of Leipzig Medical Center, Leipzig, Germany., Behrens Wu L; Department of Medicine I, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany., Rivière J; Department of Medicine III, Hematology/Oncology, School of Medicine, Klinikum rechts der Isar, München, Technical University of Munich, Munich, Germany., Rother S; Center for Molecular Signaling Präklinisches Zentrum für Molekulare Signalverarbeitung (PZMS), Saarland University School of Medicine, Homburg, Germany., Magno V; Max Bergmann Center of Biomaterials, Leibniz Institute of Polymer Research Dresden, Technische Universität (TU) Dresden, Dresden, Germany., Friedrichs J; Max Bergmann Center of Biomaterials, Leibniz Institute of Polymer Research Dresden, Technische Universität (TU) Dresden, Dresden, Germany., Werner C; Max Bergmann Center of Biomaterials, Leibniz Institute of Polymer Research Dresden, Technische Universität (TU) Dresden, Dresden, Germany., Bornhäuser M; Department of Medicine I, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany., Götze KS; Department of Medicine III, Hematology/Oncology, School of Medicine, Klinikum rechts der Isar, München, Technical University of Munich, Munich, Germany., Cross M; Medical Department I, Haematology and Cell Therapy, University of Leipzig Medical Center, Leipzig, Germany., Platzbecker U; Medical Department I, Haematology and Cell Therapy, University of Leipzig Medical Center, Leipzig, Germany., Wobus M; Department of Medicine I, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany.

Publikováno v: Frontiers in oncology [Front Oncol] 2022 Sep 08; Vol. 12, pp. 961473. Date of Electronic Publication: 2022 Sep 08 (Print Publication: 2022).