Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels.

Autor: Bailus BJ; The Buck Institute for Research on Aging, Novato, CA, USA.; School of Pharmacy and Health Sciences, Keck Graduate Institute, Claremont, CA, USA., Scheeler SM; The Buck Institute for Research on Aging, Novato, CA, USA.; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA., Simons J; The Buck Institute for Research on Aging, Novato, CA, USA., Sanchez MA; The Buck Institute for Research on Aging, Novato, CA, USA., Tshilenge KT; The Buck Institute for Research on Aging, Novato, CA, USA., Creus-Muncunill J; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Naphade S; The Buck Institute for Research on Aging, Novato, CA, USA., Lopez-Ramirez A; The Buck Institute for Research on Aging, Novato, CA, USA., Zhang N; The Buck Institute for Research on Aging, Novato, CA, USA., Lakshika Madushani K; The Buck Institute for Research on Aging, Novato, CA, USA., Moroz S; The Buck Institute for Research on Aging, Novato, CA, USA., Loureiro A; The Buck Institute for Research on Aging, Novato, CA, USA., Schreiber KH; The Buck Institute for Research on Aging, Novato, CA, USA., Hausch F; Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Darmstadt, Germany., Kennedy BK; The Buck Institute for Research on Aging, Novato, CA, USA.; Departments of Biochemistry and Physiology, Yong Loo Lin School of Medicine, National University Singapore, Singapore.; Centre for Healthy Longevity, National University Health System, Singapore., Ehrlich ME; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ellerby LM; The Buck Institute for Research on Aging, Novato, CA, USA.

Publikováno v: Autophagy [Autophagy] 2021 Dec; Vol. 17 (12), pp. 4119-4140. Date of Electronic Publication: 2021 May 24.

In Vivo Applications of Cell-Penetrating Zinc-Finger Transcription Factors.

Autor: Ren C; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA.; Guangzhou Key Laboratory of Insect Development Regulation and Application Research, South China Normal University, Guangzhou, China., Adams AN; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA., Pyles B; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA., Bailus BJ; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA.; The Buck Institute for Research on Aging, Novato, CA, USA., O'Geen H; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA., Segal DJ; Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA. djsegal@ucdavis.edu.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2018; Vol. 1867, pp. 239-251.

Protein Delivery of an Artificial Transcription Factor Restores Widespread Ube3a Expression in an Angelman Syndrome Mouse Brain.

Autor: Bailus BJ; Genome Center, MIND Institute, and Department of Biochemistry and Molecular Medicine, University of California, Davis, California, USA., Pyles B; Genome Center, MIND Institute, and Department of Biochemistry and Molecular Medicine, University of California, Davis, California, USA., McAlister MM; Genome Center, MIND Institute, and Department of Biochemistry and Molecular Medicine, University of California, Davis, California, USA., O'Geen H; Genome Center, MIND Institute, and Department of Biochemistry and Molecular Medicine, University of California, Davis, California, USA., Lockwood SH; Genome Center, MIND Institute, and Department of Biochemistry and Molecular Medicine, University of California, Davis, California, USA., Adams AN; Genome Center, MIND Institute, and Department of Biochemistry and Molecular Medicine, University of California, Davis, California, USA., Nguyen JT; Genome Center, MIND Institute, and Department of Biochemistry and Molecular Medicine, University of California, Davis, California, USA., Yu A; Genome Center, MIND Institute, and Department of Biochemistry and Molecular Medicine, University of California, Davis, California, USA., Berman RF; Department of Neurological Surgery, University of California, Davis, California, USA., Segal DJ; Genome Center, MIND Institute, and Department of Biochemistry and Molecular Medicine, University of California, Davis, California, USA.

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2016 Mar; Vol. 24 (3), pp. 548-55. Date of Electronic Publication: 2016 Jan 04.

The prospect of molecular therapy for Angelman syndrome and other monogenic neurologic disorders.

Autor: Bailus BJ, Segal DJ; Genome Center, MIND Institute, and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA 95616, USA. djsegal@ucdavis.edu.

Publikováno v: BMC neuroscience [BMC Neurosci] 2014 Jun 19; Vol. 15, pp. 76. Date of Electronic Publication: 2014 Jun 19.