Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Bailong Xiao"'
Autor:
Fan Jiang, Kunlun Yin, Kun Wu, Mingmin Zhang, Shiqiang Wang, Heping Cheng, Zhou Zhou, Bailong Xiao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The beating heart adapts cardiac output to changes in mechanical load via incompletely understood mechanotransduction mechanisms. Here the authors show that the mechanosensitive Piezo1 channel serves as a mechanotransducer for directly converting mec
Externí odkaz:
https://doaj.org/article/5ede68f3d2b2430db4de9c5749801c0f
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110342- (2022)
Summary: The mechanically activated Piezo channel plays a versatile role in conferring mechanosensitivity to various cell types. However, how it incorporates its intrinsic mechanosensitivity and cellular components to effectively sense long-range mec
Externí odkaz:
https://doaj.org/article/4ee79486640e4b35ae4599fbded5908b
Autor:
Yao Rong, Jinghui Jiang, Yiwei Gao, Jianli Guo, Danfeng Song, Wenhao Liu, Mingmin Zhang, Yan Zhao, Bailong Xiao, Zhenfeng Liu
Publikováno v:
eLife, Vol 10 (2021)
TMEM120A, a member of the transmembrane protein 120 (TMEM120) family, has a pivotal function in adipocyte differentiation and metabolism, and may also contribute to sensing mechanical pain by functioning as an ion channel named TACAN. Here we report
Externí odkaz:
https://doaj.org/article/2c1e845af19e41d38509e00b21d3eed6
Autor:
Yanfeng Wang, Shaopeng Chi, Huifang Guo, Guang Li, Li Wang, Qiancheng Zhao, Yu Rao, Liansuo Zu, Wei He, Bailong Xiao
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Piezo1 is a large trimeric ion channel activated by mechanical stimulus. Here the authors identify chemical activators of Piezo1 that utilize a lever-like mechanotransduction pathway for long-range allosteric gating.
Externí odkaz:
https://doaj.org/article/c9e4bf37c751415aba8d06d398c7970c
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Mechanosensitive Piezo channels are important for a wide range of mechanotransduction processes. Here the authors show that Piezos interact with sarcoplasmic /endoplasmic-reticulum Ca2+ ATPases (SERCA) and give mechanistic insights into mechanogating
Externí odkaz:
https://doaj.org/article/6beba7b2efeb4c08b83cd2137e93cc51
Autor:
Weijia Sun, Shaopeng Chi, Yuheng Li, Shukuan Ling, Yingjun Tan, Youjia Xu, Fan Jiang, Jianwei Li, Caizhi Liu, Guohui Zhong, Dengchao Cao, Xiaoyan Jin, Dingsheng Zhao, Xingcheng Gao, Zizhong Liu, Bailong Xiao, Yingxian Li
Publikováno v:
eLife, Vol 8 (2019)
Mechanical load of the skeleton system is essential for the development, growth, and maintenance of bone. However, the molecular mechanism by which mechanical stimuli are converted into osteogenesis and bone formation remains unclear. Here we report
Externí odkaz:
https://doaj.org/article/def7f427e6634ab4b60a3af8dcbdf0aa
Publikováno v:
Cell Reports, Vol 26, Iss 6, Pp 1419-1431.e4 (2019)
Summary: Touch and mechanical pain represent distinct, but interactive, modalities of mechanosensation. However, the molecular mechanisms underlying these mechanotransduction processes remain incompletely understood. Here, we show that deletion of th
Externí odkaz:
https://doaj.org/article/a931b31391da4a8b8421a264550b7530
Autor:
Adrienne E. Dubin, Manuela Schmidt, Jayanti Mathur, Matthew J. Petrus, Bailong Xiao, Bertrand Coste, Ardem Patapoutian
Publikováno v:
Cell Reports, Vol 2, Iss 3, Pp 511-517 (2012)
Heightened nociceptor function caused by inflammatory mediators such as bradykinin (BK) contributes to increased pain sensitivity (hyperalgesia) to noxious mechanical and thermal stimuli. Although it is known that sensitization of the heat transducer
Externí odkaz:
https://doaj.org/article/a280bf8878e849079744627b696ecefa
Autor:
Liang Guo, Qionglei Mao, Ji He, Xiaoling Liu, Xuejiao Piao, Li Luo, Xiaoxu Hao, Hanzhi Yu, Qiang Song, Bailong Xiao, Dongsheng Fan, Zhaobing Gao, Yichang Jia
Publikováno v:
Cell Research.
Although anion channel activities have been demonstrated in sarcoplasmic reticulum/endoplasmic reticulum (SR/ER), their molecular identities and functions remain unclear. Here, we link rare variants of Chloride Channel CLIC Like 1 (CLCC1) to amyotrop
Autor:
Yue Wan, Haiping Wang, Xiaowei Fan, Jiayu Bao, Shen Wu, Qian Liu, Xuejing Yan, Jingxue Zhang, Zi‐bing Jin, Bailong Xiao, Ningli Wang
Publikováno v:
Glia. 71