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The unique ORF8 protein from SARS-CoV-2 binds to human dendritic cells and induces a hyper-inflammatory cytokine storm.

Autor: Hamdorf M; Cornea Lab Experimental Ophthalmology, Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, 50937 Cologne, Germany.; Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA., Imhof T; Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, 50931 Cologne, Germany.; Institute for Experimental Dentistry and Oral Musculoskeletal Biology, Faculty of Medicine and University Hospital Cologne, 50931 Cologne, Germany., Bailey-Elkin B; Department of Microbiology, University of Manitoba, Winnipeg MB R3B 2E9 Manitoba, Canada., Betz J; Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, 50931 Cologne, Germany.; Institute for Experimental Dentistry and Oral Musculoskeletal Biology, Faculty of Medicine and University Hospital Cologne, 50931 Cologne, Germany., Theobald SJ; Department I of Internal Medicine, Division of Infectious Diseases, Faculty of Medicine and University Hospital Cologne, 50937 Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany., Simonis A; Department I of Internal Medicine, Division of Infectious Diseases, Faculty of Medicine and University Hospital Cologne, 50937 Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany., Di Cristanziano V; Institute of Virology, Faculty of Medicine and University Hospital Cologne, 50935 Cologne, Germany., Gieselmann L; Institute of Virology, Faculty of Medicine and University Hospital Cologne, 50935 Cologne, Germany., Dewald F; Institute of Virology, Faculty of Medicine and University Hospital Cologne, 50935 Cologne, Germany., Lehmann C; Department I of Internal Medicine, Division of Infectious Diseases, Faculty of Medicine and University Hospital Cologne, 50937 Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, 50931 Cologne, Germany., Augustin M; Department I of Internal Medicine, Division of Infectious Diseases, Faculty of Medicine and University Hospital Cologne, 50937 Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, 50931 Cologne, Germany., Klein F; Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany.; Institute of Virology, Faculty of Medicine and University Hospital Cologne, 50935 Cologne, Germany.; German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, 50931 Cologne, Germany., Alejandre Alcazar MA; Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany.; Department of Children and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, 50931 Cologne, Germany.; Cologne Excellence Cluster Stress Responses in Aging-associated Diseases, 50931 Cologne, Germany.; Institute for Lung Health (ILH), Universities of Gießen and Marburg Lung Centre, Member of the German Center for Lung Research, 35392 Gießen, Germany., Rongisch R; Dermatology, Faculty of Medicine and University Hospital Cologne, 50937 Cologne, Germany., Fabri M; Dermatology, Faculty of Medicine and University Hospital Cologne, 50937 Cologne, Germany., Rybniker J; Department I of Internal Medicine, Division of Infectious Diseases, Faculty of Medicine and University Hospital Cologne, 50937 Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany., Goebel H; Institute of Pathology, Faculty of Medicine and University Hospital Cologne, 50937 Cologne, Germany., Stetefeld J; Department of Microbiology, University of Manitoba, Winnipeg MB R3B 2E9 Manitoba, Canada., Brachvogel B; Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, 50931 Cologne, Germany.; Department of Pediatrics and Adolescent Medicine, Experimental Neonatology, Faculty of Medicine and University Hospital Cologne, 50931 Cologne, Germany., Cursiefen C; Cornea Lab Experimental Ophthalmology, Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, 50937 Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany., Koch M; Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, 50931 Cologne, Germany.; Institute for Experimental Dentistry and Oral Musculoskeletal Biology, Faculty of Medicine and University Hospital Cologne, 50931 Cologne, Germany., Bock F; Cornea Lab Experimental Ophthalmology, Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, 50937 Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany.

Publikováno v: Journal of molecular cell biology [J Mol Cell Biol] 2024 Apr 04; Vol. 15 (10).