Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin.

Autor: Ho GY; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; The Royal Women's Hospital, Parkville, Victoria, Australia., Kyran EL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Cancer Research UK Cambridge Institute, Cambridge, United Kingdom., Bedo J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; School of Computing and Information Systems, the University of Melbourne, Parkville, Victoria, Australia., Wakefield MJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia., Ennis DP; Division of Cancer and Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom.; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom., Mirza HB; Division of Cancer and Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom., Vandenberg CJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Lieschke E; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Farrell A; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Hadla A; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Lim R; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Dall G; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Vince JE; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Chua NK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Kondrashova O; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Upstill-Goddard R; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom., Bailey UM; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom., Dowson S; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom., Roxburgh P; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom.; Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom., Glasspool RM; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom.; Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom., Bryson G; Department of Pathology, Queen Elizabeth University Hospital, Glasgow, United Kingdom., Biankin AV; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom., Cooke SL; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom., Ratnayake G; The Royal Women's Hospital, Parkville, Victoria, Australia., McNally O; The Royal Women's Hospital, Parkville, Victoria, Australia.; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.; Sir Peter MacCallum Cancer Centre Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., Traficante N; Sir Peter MacCallum Cancer Centre Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., DeFazio A; Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, Australia.; The Daffodil Centre, The University of Sydney, A Joint Venture with Cancer Council NSW, Sydney, Australia.; Department of Gynaecological Oncology, Westmead Hospital, Sydney, Australia., Weroha SJ; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Bowtell DD; Sir Peter MacCallum Cancer Centre Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., McNeish IA; Division of Cancer and Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom.; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom.; Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom., Papenfuss AT; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Scott CL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; The Royal Women's Hospital, Parkville, Victoria, Australia.; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.; Sir Peter MacCallum Cancer Centre Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., Barker HE; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.

Publikováno v: Cancer research [Cancer Res] 2022 Dec 02; Vol. 82 (23), pp. 4457-4473.

Using Chromatin Accessibility to Delineate Therapeutic Subtypes in Pancreatic Cancer Patient-Derived Cell Lines.

Autor: Brunton H; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1QH, UK.; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Garner IM; Epigenetics Unit, Department of Surgery & Cancer, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK., Bailey UM; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK., Upstill-Goddard R; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1QH, UK., Bailey PJ; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1QH, UK.; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.; Department of General surgery, University of Heidelberg, 69120 Heidelberg, Germany.

Publikováno v: STAR protocols [STAR Protoc] 2020 Aug 04; Vol. 1 (2), pp. 100079. Date of Electronic Publication: 2020 Aug 04 (Print Publication: 2020).

Genomic analyses identify molecular subtypes of pancreatic cancer.

Autor: Bailey P; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK., Chang DK; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.; Department of Surgery, Bankstown Hospital, Eldridge Road, Bankstown, Sydney, New South Wales 2200, Australia.; South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Liverpool, New South Wales 2170, Australia., Nones K; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia., Johns AL; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Patch AM; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia., Gingras MC; Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.; Michael DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA.; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA., Miller DK; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Christ AN; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Bruxner TJ; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Quinn MC; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia., Nourse C; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK., Murtaugh LC; Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112, USA., Harliwong I; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Idrisoglu S; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Manning S; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Nourbakhsh E; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Wani S; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia., Fink L; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Holmes O; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia., Chin V; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Anderson MJ; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Kazakoff S; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia., Leonard C; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia., Newell F; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Waddell N; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Wood S; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia., Xu Q; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia., Wilson PJ; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Cloonan N; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia., Kassahn KS; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; Genetic and Molecular Pathology, SA Pathology, Adelaide, South Australia 5000, Australia.; School of Biological Sciences, The University of Adelaide, Adelaide, South Australia 5000, Australia., Taylor D; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Quek K; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Robertson A; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia., Pantano L; Harvard Chan Bioinformatics Core, Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115, USA., Mincarelli L; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK., Sanchez LN; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK., Evers L; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK., Wu J; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Pinese M; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Cowley MJ; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Jones MD; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Colvin EK; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Nagrial AM; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Humphrey ES; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Chantrill LA; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.; Macarthur Cancer Therapy Centre, Campbelltown Hospital, New South Wales 2560, Australia., Mawson A; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Humphris J; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Chou A; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.; Department of Pathology. SydPath, St Vincent's Hospital, Sydney, NSW 2010, Australia., Pajic M; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.; St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, New South Wales 2052, Australia., Scarlett CJ; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.; School of Environmental &Life Sciences, University of Newcastle, Ourimbah, New South Wales 2258, Australia., Pinho AV; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Giry-Laterriere M; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Rooman I; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Samra JS; Department of Surgery, Royal North Shore Hospital, St Leonards, Sydney, New South Wales 2065, Australia.; University of Sydney, Sydney, New South Wales 2006, Australia., Kench JG; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.; University of Sydney, Sydney, New South Wales 2006, Australia.; Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Camperdown New South Wales 2050, Australia., Lovell JA; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Merrett ND; South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Liverpool, New South Wales 2170, Australia.; School of Medicine, University of Western Sydney, Penrith, New South Wales 2175, Australia., Toon CW; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Epari K; Fiona Stanley Hospital, Robin Warren Drive, Murdoch, Western Australia 6150, Australia., Nguyen NQ; Department of Gastroenterology, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia., Barbour A; Department of Surgery, Princess Alexandra Hospital, Ipswich Rd, Woollongabba, Queensland 4102, Australia., Zeps N; School of Surgery M507, University of Western Australia, 35 Stirling Hwy, Nedlands 6009, Australia and St John of God Pathology, 12 Salvado Rd, Subiaco, Western Australia 6008, Australia., Moran-Jones K; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK., Jamieson NB; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.; Academic Unit of Surgery, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow Royal Infirmary, Glasgow G4 OSF, UK.; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow G31 2ER, UK., Graham JS; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.; Department of Medical Oncology, Beatson West of Scotland Cancer Centre, 1053 Great Western Road, Glasgow G12 0YN, UK., Duthie F; Department of Pathology, Southern General Hospital, Greater Glasgow &Clyde NHS, Glasgow G51 4TF, UK., Oien K; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.; Department of Pathology, Southern General Hospital, Greater Glasgow &Clyde NHS, Glasgow G51 4TF, UK., Hair J; GGC Bio-repository, Pathology Department, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TY, UK., Grützmann R; Department of Surgery, TU Dresden, Fetscherstr. 74, 01307 Dresden, Germany., Maitra A; Departments of Pathology and Translational Molecular Pathology, UT MD Anderson Cancer Center, Houston Texas 77030, USA., Iacobuzio-Donahue CA; The David M. Rubenstein Pancreatic Cancer Research Center and Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Wolfgang CL; Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.; Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA., Morgan RA; Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA., Lawlor RT; ARC-Net Applied Research on Cancer Centre, University and Hospital Trust of Verona, Verona 37134, Italy.; Department of Pathology and Diagnostics, University of Verona, Verona 37134, Italy., Corbo V; ARC-Net Applied Research on Cancer Centre, University and Hospital Trust of Verona, Verona 37134, Italy., Bassi C; Department of Surgery, Pancreas Institute, University and Hospital Trust of Verona, Verona 37134, Italy., Rusev B; ARC-Net Applied Research on Cancer Centre, University and Hospital Trust of Verona, Verona 37134, Italy., Capelli P; Department of Pathology and Diagnostics, University of Verona, Verona 37134, Italy., Salvia R; Department of Surgery, Pancreas Institute, University and Hospital Trust of Verona, Verona 37134, Italy., Tortora G; Department of Medical Oncology, Comprehensive Cancer Centre, University and Hospital Trust of Verona, Verona 37134, Italy., Mukhopadhyay D; Mayo Clinic, Rochester, Minnesota 55905, USA., Petersen GM; Mayo Clinic, Rochester, Minnesota 55905, USA., Munzy DM; Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.; Michael DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA., Fisher WE; Elkins Pancreas Center, Baylor College of Medicine, One Baylor Plaza, MS226, Houston, Texas 77030-3411, USA., Karim SA; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK., Eshleman JR; Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA., Hruban RH; Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA., Pilarsky C; Department of Surgery, TU Dresden, Fetscherstr. 74, 01307 Dresden, Germany., Morton JP; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK., Sansom OJ; Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.; Institute for Cancer Science, University of Glasgow, Glasgow G12 8QQ, UK., Scarpa A; ARC-Net Applied Research on Cancer Centre, University and Hospital Trust of Verona, Verona 37134, Italy.; Department of Pathology and Diagnostics, University of Verona, Verona 37134, Italy., Musgrove EA; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK., Bailey UM; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK., Hofmann O; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.; Harvard Chan Bioinformatics Core, Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115, USA., Sutherland RL; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia., Wheeler DA; Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.; Michael DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA., Gill AJ; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.; University of Sydney, Sydney, New South Wales 2006, Australia., Gibbs RA; Department of Molecular and Human Genetics, Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA.; Michael DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA., Pearson JV; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia., Waddell N; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; QIMR Berghofer Medical Research Institute, Herston, Queensland 4006, Australia., Biankin AV; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.; The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, and the Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney, New South Wales 2010, Australia.; Department of Surgery, Bankstown Hospital, Eldridge Road, Bankstown, Sydney, New South Wales 2200, Australia.; South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Liverpool, New South Wales 2170, Australia.; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow G31 2ER, UK., Grimmond SM; Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia.; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK.; University of Melbourne, Parkville, Victoria 3010, Australia.

Publikováno v: Nature [Nature] 2016 Mar 03; Vol. 531 (7592), pp. 47-52. Date of Electronic Publication: 2016 Feb 24.

Chemical probing suggests redox-regulation of the carbonic anhydrase activity of mycobacterial Rv1284.

Autor: Nienaber L; Eskitis Institute, Griffith University, Nathan, Queensland, Australia., Cave-Freeman E; Eskitis Institute, Griffith University, Nathan, Queensland, Australia., Cross M; Eskitis Institute, Griffith University, Nathan, Queensland, Australia., Mason L; Eskitis Institute, Griffith University, Nathan, Queensland, Australia., Bailey UM; Eskitis Institute, Griffith University, Nathan, Queensland, Australia., Amani P; Eskitis Institute, Griffith University, Nathan, Queensland, Australia., A Davis R; Eskitis Institute, Griffith University, Nathan, Queensland, Australia.; Queensland Tropical Health Alliance, Smithfield, Australia., Taylor P; School of Biological Sciences, The University of Edinburgh, Scotland, UK., Hofmann A; Eskitis Institute, Griffith University, Nathan, Queensland, Australia.; Queensland Tropical Health Alliance, Smithfield, Australia.; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria, Australia.

Publikováno v: The FEBS journal [FEBS J] 2015 Jul; Vol. 282 (14), pp. 2708-21. Date of Electronic Publication: 2015 May 18.

A practical Java tool for small-molecule compound appraisal.

Autor: Amani P; Structural Chemistry Program, Eskitis Institute, Griffith University, Nathan, QLD Australia., Sneyd T; Structural Chemistry Program, Eskitis Institute, Griffith University, Nathan, QLD Australia., Preston S; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC Australia., Young ND; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC Australia., Mason L; Structural Chemistry Program, Eskitis Institute, Griffith University, Nathan, QLD Australia., Bailey UM; Structural Chemistry Program, Eskitis Institute, Griffith University, Nathan, QLD Australia., Baell J; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences (MIPS), Monash University, Parkville, VIC Australia., Camp D; Griffith School of Environment, Griffith University, Nathan, QLD Australia., Gasser RB; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC Australia., Gorse AD; Queensland Facility for Advanced Bioinformatics, Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD Australia., Taylor P; School of Biological Sciences, The University of Edinburgh, Edinburgh, Scotland, UK., Hofmann A; Structural Chemistry Program, Eskitis Institute, Griffith University, Nathan, QLD Australia ; Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC Australia.

Publikováno v: Journal of cheminformatics [J Cheminform] 2015 Jun 16; Vol. 7, pp. 28. Date of Electronic Publication: 2015 Jun 16 (Print Publication: 2015).