Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Bailey Cooke"'
Autor:
Alexandra D’Oto, Jie Fang, Hongjian Jin, Beisi Xu, Shivendra Singh, Anoushka Mullasseril, Victoria Jones, Ahmed Abu-Zaid, Xinyu von Buttlar, Bailey Cooke, Dongli Hu, Jason Shohet, Andrew J. Murphy, Andrew M. Davidoff, Jun Yang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The histone demethylase KDM6B is reported to be essential for neuroblastoma cell survival. Here the authors show that KDM6B regulates CDK4/6-pRB-E2F pathway through H3K27me3-dependent enhancer-promoter interactions in neuroblastoma.
Externí odkaz:
https://doaj.org/article/2ad9ab2b23fe41648721a58a68144d5b
Autor:
Shivendra Singh, Ahmed Abu-Zaid, Wenwei Lin, Jonathan Low, Alireza Abdolvahabi, Hongjian Jin, Qiong Wu, Bailey Cooke, Jie Fang, John Bowling, Sivaraja Vaithiyalingam, Duane Currier, Mi-Kyung Yun, Dinesh M. Fernando, Julie Maier, Heather Tillman, Purva Bulsara, Zhaohua Lu, Sourav Das, Anang Shelat, Zhenmei Li, Brandon Young, Richard Lee, Zoran Rankovic, Andrew J. Murphy, Stephen W. White, Andrew M. Davidoff, Taosheng Chen, Jun Yang
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101996- (2021)
Summary: Histone lysine demethylases (KDMs) play critical roles in oncogenesis and therefore may be effective targets for anticancer therapy. Using a time-resolved fluorescence resonance energy transfer demethylation screen assay, in combination with
Externí odkaz:
https://doaj.org/article/06c582be98bb44abbf752e112dc13534
Autor:
Andrew J. Murphy, Jason M. Shohet, Alexandra D’Oto, Dongli Hu, Xinyu von Buttlar, Andrew M. Davidoff, Beisi Xu, Bailey Cooke, Jun J. Yang, Shivendra V. Singh, Victoria Jones, Anoushka Mullasseril, Hongjian Jin, Jie Fang, Ahmed Abu-Zaid
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
The H3K27me2/me3 histone demethylase KDM6B is essential to neuroblastoma cell survival. However, the mechanism of KDM6B action remains poorly defined. We demonstrate that inhibition of KDM6B activity 1) reduces the chromatin accessibility of E2F targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da49739893ca1a7c26cbefa1e9542786
https://doi.org/10.1038/s41467-021-27502-2
https://doi.org/10.1038/s41467-021-27502-2
Autor:
Ahmed Abu-Zaid, Sivaraja Vaithiyalingam, Brandon Young, Sourav Das, Heather Tillman, Bailey Cooke, Alireza Abdolvahabi, Julie Maier, Jonathan Low, Taosheng Chen, Jun J. Yang, Andrew M. Davidoff, Zhenmei Li, John J. Bowling, Hongjian Jin, Shivendra V. Singh, Jie Fang, Purva Bulsara, Wenwei Lin, Zoran Rankovic, Duane G. Currier, Andrew J. Murphy, Zhaohua Lu, Richard E. Lee, Anang A. Shelat, Dinesh M. Fernando, Qiong Wu, Stephen W. White, Mi-Kyung Yun
Publikováno v:
iScience
iScience, Vol 24, Iss 1, Pp 101996-(2021)
iScience, Vol 24, Iss 1, Pp 101996-(2021)
Summary Histone lysine demethylases (KDMs) play critical roles in oncogenesis and therefore may be effective targets for anticancer therapy. Using a time-resolved fluorescence resonance energy transfer demethylation screen assay, in combination with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc8fae1c6e40b2ac715a77fb2977e6c
http://europepmc.org/articles/PMC7811140
http://europepmc.org/articles/PMC7811140
Autor:
Jonathan Low, Brandon Young, Jun J. Yang, John J. Bowling, Zoran Rankovic, Dinesh M. Fernando, Andrew M. Davidoff, Zhenmei Li, Bailey Cooke, Duane G. Currier, Stephen W. White, Jie Fang, Ahmed Abu-Zaid, Julie Maier, Heather Tillman, Zhaohua Lu, Sourav Das, Shivendra V. Singh, Taosheng Chen, Sivaraja Vaithiyalingam, Purva Bulsara, Wenwei Lin, Richard E. Lee, Alaa Altahan, Mi-Kyung Yun, Alireza Abdolvahabi
Histone lysine demethylases (KDMs) are emerging as therapeutic targets in cancer. Development of potent KDM inhibitors may provide additional options for epigenomics-oriented therapies. Using a Time-Resolved Fluorescence Resonance Energy Transfer (TR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1ac2240ce64466e93c8e36ffb99c2a
