Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Bailey C. Montefiore"'
Autor:
Koen J. Dechering, Martijn Timmerman, Kim Rensen, Karin M.J. Koolen, Saman Honarnejad, Martijn W. Vos, Tonnie Huijs, Rob W.M. Henderson, Elodie Chenu, Benoît Laleu, Bailey C. Montefiore, Matthew D. Segall, James E.J. Mills, Eric M. Guantai, James Duffy, Maëlle Duffey
Publikováno v:
SLAS Discovery, Vol 27, Iss 6, Pp 337-348 (2022)
A central challenge of antimalarial therapy is the emergence of resistance to the components of artemisinin-based combination therapies (ACTs) and the urgent need for new drugs acting through novel mechanism of action. Over the last decade, compounds
Externí odkaz:
https://doaj.org/article/5462a223647e4fcf83104fa393c505f1
Autor:
Judith Reeks, James R. Ault, Martyna W. Pastok, Natalie J. Tatum, Svitlana Korolchuk, Mengxi Liu, Martin E.M. Noble, Richard A Heath, Frank Sobott, Bailey C. Montefiore, D.J. Wood, Lan-Zhen Wang, Michele Pagano, Jane A. Endicott, Marco Salamina, Arnaud Baslé, Stefan T. Arold
Publikováno v:
Journal of Molecular Biology
Graphical abstract
Highlights • SKP2 engages a site on the N-terminal lobe of cyclin A. • SKP2 recruits a catalytic CDK2-cyclin A to CDK2-cyclin A-CKS1-p27KIP1-SKP1-SKP2. • The SKP2 and p27KIP1 binding sites on cyclin A are divergent but o
Highlights • SKP2 engages a site on the N-terminal lobe of cyclin A. • SKP2 recruits a catalytic CDK2-cyclin A to CDK2-cyclin A-CKS1-p27KIP1-SKP1-SKP2. • The SKP2 and p27KIP1 binding sites on cyclin A are divergent but o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9746668e50adfe7324966d3acc066eea
https://pubmed.ncbi.nlm.nih.gov/33422522
https://pubmed.ncbi.nlm.nih.gov/33422522
Autor:
Arnaud Baslé, Natalie J. Tatum, Frank Sobott, Stefan T. Arold, Marco Salamina, Bailey C. Montefiore, Richard A Heath, Martin E.M. Noble, Judith Reeks, D.J. Wood, Lan-Zhen Wang, Michele Pagano, Mengxi Liu, Svitlana Korolchuk, Jane A. Endicott, Martyna W. Pastok, James R. Ault
The SCFSKP2 ubiquitin ligase relieves G1 checkpoint control of CDK-cyclin complexes by promoting p27KIP1 degradation. We describe reconstitution of stable complexes containing SKP1-SKP2 and CDK1-cyclin B or CDK2-cyclin A/E, mediated by the CDK regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d1af534de89e8bab164434dd0bc2f1a
https://doi.org/10.1101/2020.10.08.329599
https://doi.org/10.1101/2020.10.08.329599
