Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Bailey Baumann"'
Autor:
Jacob K. Sterling, Bailey Baumann, Sierra Foshe, Andrew Voigt, Samyuktha Guttha, Ahab Alnemri, Sam J. McCright, Mingyao Li, Randy J. Zauhar, Sandra R. Montezuma, Rebecca J. Kapphahn, Venkata R.M. Chavali, David A. Hill, Deborah A. Ferrington, Dwight Stambolian, Robert F. Mullins, David Merrick, Joshua L. Dunaief
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110942- (2022)
Summary: Age-related macular degeneration (AMD), the leading cause of irreversible blindness among Americans over 50, is characterized by dysfunction and death of retinal pigment epithelial (RPE) cells. The RPE accumulates iron in AMD, and iron overl
Externí odkaz:
https://doaj.org/article/a701cd56ed6f48bc9d2e45ba3c34f5f4
Autor:
Reas S. Khan, Bailey Baumann, Kimberly Dine, Ying Song, Joshua L. Dunaief, Sangwon F. Kim, Kenneth S. Shindler
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Dysregulation of iron metabolism, and resultant cytotoxicity, has been implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative processes. Iron accumulation promotes cytotoxicity through various mechanisms includ
Externí odkaz:
https://doaj.org/article/d0bc350eede54e77b57423da0e937210
Autor:
Kevin R. Zhang, Bailey Baumann, Ying Song, Jacob Sterling, Elizabeth A. Erler, Samyuktha Guttha, Zbynek Kozmik, Joshua L. Dunaief
Publikováno v:
Exp Eye Res
Iron accumulation has been implicated in degenerative retinal diseases. It can catalyze the production of damaging reactive oxygen species. Previous work has demonstrated iron accumulation in multiple retinal diseases, including age-related macular d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f93860c0ab44cd6a9616f9b877476c8
https://europepmc.org/articles/PMC9050911/
https://europepmc.org/articles/PMC9050911/
Autor:
Yingrui Liu, Bailey Baumann, Ying Song, Kevin Zhang, Jacob K. Sterling, Samira Lakhal-Littleton, Zbynek Kozmik, Guanfang Su, Joshua L. Dunaief
Publikováno v:
Exp Eye Res
Iron-induced oxidative stress can cause or exacerbate retinal degenerative diseases. Retinal iron overload has been reported in several mouse disease models with systemic or neural retina-specific knockout (KO) of homologous ferroxidases ceruloplasmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff70c48ee8526a79dde6032d052acaa5
https://europepmc.org/articles/PMC9050912/
https://europepmc.org/articles/PMC9050912/
Autor:
Jacob K. Sterling, Tae-In Kam, Samyuktha Guttha, Hyejin Park, Bailey Baumann, Amir A. Mehrabani-Tabari, Hannah Schultz, Brandon Anderson, Ahab Alnemri, Shih-Ching Chou, Juan C. Troncoso, Valina L. Dawson, Ted M. Dawson, Joshua L. Dunaief
Publikováno v:
Cell Reports. 38:110358
α-synuclein (α-syn) aggregation and accumulation drive neurodegeneration in Parkinson's disease (PD). The substantia nigra of patients with PD contains excess iron, yet the underlying mechanism accounting for this iron accumulation is unclear. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ec1dbfc491f73f25bcdcdbb2e1bc2d
https://doi.org/10.1016/j.celrep.2022.110358
https://doi.org/10.1016/j.celrep.2022.110358
Autor:
Ying Song, Bailey Baumann, Samira Lakhal-Littleton, Zbynek Kozmik, Joshua L. Dunaief, Wanting Shu, Jacob Sterling
Publikováno v:
Am J Pathol
The liver secretes hepcidin (Hepc) into the bloodstream to reduce blood iron levels. Hepc accomplishes this by triggering degradation of the only known cellular iron exporter ferroportin in the gut, macrophages, and liver. We previously demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e520d0dc05dadbf43964bb7cdef829
https://europepmc.org/articles/PMC6723216/
https://europepmc.org/articles/PMC6723216/
Autor:
Deborah A. Ferrington, Sandra R. Montezuma, Bailey Baumann, Hannah Schultz, Rebecca J. Kapphahn, Joshua L. Dunaief, Ying Song
Publikováno v:
Exp Eye Res
The blood retinal barrier (BRB) closely regulates the retinal microenvironment. Its compromise leads to the accumulation of retinal fluid containing potentially harmful plasma components. While eyes with non-exudative age-related macular degeneration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac02b943ffeb3a0e89935ac170c8c2b7
https://pubmed.ncbi.nlm.nih.gov/31158383
https://pubmed.ncbi.nlm.nih.gov/31158383
Autor:
Bailey Baumann, Reas S. Khan, Joshua L. Dunaief, Kenneth S. Shindler, Sangwon F. Kim, Ying Song, Kimberly Dine
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Dysregulation of iron metabolism, and resultant cytotoxicity, has been implicated in the pathogenesis of multiple sclerosis (MS) and other neurodegenerative processes. Iron accumulation promotes cytotoxicity through various mechanisms including oxida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a2e5d2ae4d5c90816911aeaf8db9d3
https://pubmed.ncbi.nlm.nih.gov/31406150
https://pubmed.ncbi.nlm.nih.gov/31406150
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Iron supplementation therapy is used for iron-deficiency anemia but has been associated with macular degeneration in a 43-year-old patient. Iron entry into the neurosensory retina (NSR) can be toxic. It is important to determine conditions un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a8b9e0bd4303de7d79d6830b0b587e
https://doi.org/10.1167/iovs.19-28250
https://doi.org/10.1167/iovs.19-28250
Autor:
Bailey Baumann, Elizabeth M. Simpson, Wanting Shu, Ying Song, Samira Lakhal-Littleton, Joshua L. Dunaief
Publikováno v:
Exp Eye Res
Retinal iron accumulation has been implicated in the pathogenesis of age-related macular degeneration (AMD) and other neurodegenerative diseases. The retina and the brain are protected from the systemic circulation by the blood retinal barrier (BRB)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffa561944439e7b264fe10e0f96cbbf
https://doi.org/10.1016/j.exer.2019.107728
https://doi.org/10.1016/j.exer.2019.107728