Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery

Autor: Shoemark, Deborah K, Williams, Christopher, Fahey, Mark S, Watson, Judy J, Tyler, Sue J, Scoltock, Simon J, Ellis, Rosamund, Wickendon, Elaine, Burton, Antony J, Hemmings, Jennifer Luise L, Bailey, Christopher D, Dawbarn, David, Jane, David E, Willis, Chris L, Sessions, Richard B, Allen , Shelley J, Crump, Matthew P

Publikováno v: Shoemark, D K, Williams, C, Fahey, M S, Watson, J J, Tyler, S J, Scoltock, S J, Ellis, R, Wickendon, E, Burton, A J, Hemmings, J L L, Bailey, C D, Dawbarn, D, Jane, D E, Willis, C L, Sessions, R B, Allen, S J & Crump, M P 2015, ' Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery ', Journal of Medicinal Chemistry, vol. 58, no. 2, pp. 767-777 . https://doi.org/10.1021/jm501307e

The tyrosine kinase A (TrkA) receptor is a validated therapeutic intervention point for a wide range of conditions. TrkA activation by nerve growth factor (NGF) binding the second extracellular immunoglobulin (TrkAIg2) domain, triggers intracellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2642::42630e8d534f8036916a0099b5032282
https://hdl.handle.net/1983/ef88c645-344d-43d5-af15-69ecf8224f68

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Design and Nuclear MagneticResonance (NMR) StructureDetermination of the Second Extracellular Immunoglobulin TyrosineKinase A (TrkAIg2) Domain Construct for Binding Site Elucidation inDrug Discovery.

Autor: Shoemark, Debbie K., Williams, Christopher, Fahey, Mark S., Watson, Judy J., Tyler, Sue J., Scoltock, Simon J., Ellis, Rosamund Z., Wickenden, Elaine, Burton, Antony J., Hemmings, Jennifer L., Bailey, Christopher D., Dawbarn, David, Jane, David E., Willis, Christine L., Sessions, Richard B., Allen, Shelley J., Crump, Matthew P.

Publikováno v: Journal of Medicinal Chemistry; Jan2015, Vol. 58 Issue 2, p767-777, 11p

Bicyclic Oxygen Heterocycles from γ,δ-Unsaturated Alcohols: Synthetic Targets Inspired by Blepharocalyxin D.

Autor: Bunt, Adam J., Bailey, Christopher D., Cons, Benjamin D., Edwards, Sophie J., Elsworth, Jon D., Pheko, Tshepo, Willis, Christine L.

Publikováno v: Angewandte Chemie; Apr2012, Vol. 124 Issue 16, p3967-3970, 4p

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.