Identification and analysis of novel small molecule inhibitors of RNase E: Implications for antibacterial targeting and regulation of RNase E

Autor: Helen S. Atkins, Louise E. Butt, Paul A. Cox, Bailei C. Spelman, Anastasia J. Callaghan, Charlotte E. Mardle, Darren M. Gowers, Layla R. Goddard, Helen A. Vincent

Publikováno v: Biochemistry and Biophysics Reports
Mardle, C E, Goddard, L, Spelman, B C, Atkins, H S, Butt, L, Cox, P, Gowers, D, Vincent, H & Callaghan, A 2020, ' Identification and analysis of novel small molecule inhibitors of RNase E: implications for antibacterial targeting and regulation of RNase E ', Biochemistry and Biophysics Reports, vol. 23, 100773 . https://doi.org/10.1016/j.bbrep.2020.100773
Biochemistry and Biophysics Reports, Vol 23, Iss, Pp 100773-(2020)

Increasing resistance of bacteria to antibiotics is a serious global challenge and there is a need to unlock the potential of novel antibacterial targets. One such target is the essential prokaryotic endoribonuclease RNase E. Using a combination of i

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http://europepmc.org/articles/PMC7284133