Fibroblastic reticular cells in lymph node potentiate white adipose tissue beiging through neuro-immune crosstalk in male mice

Autor: Lai Yee Cheong, Baile Wang, Qin Wang, Leigang Jin, Kelvin H. M. Kwok, Xiaoping Wu, Lingling Shu, Huige Lin, Sookja Kim Chung, Kenneth K. Y. Cheng, Ruby L. C. Hoo, Aimin Xu

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Beiging and thermogenesis in white adipose tissue (WAT) is an important adaptive response to cold exposure, but how the brain senses cold and subsequently induces beiging remains unclear. Here, the authors show that sympathetic nerves stimulate lymph

Externí odkaz: https://doaj.org/article/855172dea7104e12b8e6ff973eaba45e

The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic β-cells

Autor: Wenqi Lu, Kenneth K.Y. Cheng, Xiaomu Li, Huige Lin, Aimin Xu, Baile Wang, Jae Bum Kim

Publikováno v: Proc Natl Acad Sci U S A

Filamentous actin (F-actin) cytoskeletal remodeling is critical for glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells, and its dysregulation causes type 2 diabetes. The adaptor protein APPL1 promotes first-phase GSIS by up-regulating

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86355a6ef4aa1e8ef9a25e1da34292d
https://pubmed.ncbi.nlm.nih.gov/33122440

The Dysfunctional MDM2–p53 Axis in Adipocytes Contributes to Aging-Related Metabolic Complications by Induction of Lipodystrophy

Autor: Zhuohao Liu, Jin Kui Yang, Kenneth K.Y. Cheng, Philip Hallenborg, Baile Wang, Leigang Jin, Kelvin K.L. Wu, Aimin Xu

Publikováno v: Liu, Z, Jin, L, Yang, J-K, Wang, B, Wu, K K, Hallenborg, P, Xu, A & Cheng, K K 2018, ' The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Ageing Related Metabolic Complications by Induction of Lipodystrophy ', Diabetes, vol. 67, no. 11, pp. 2397-2409 . https://doi.org/10.2337/db18-0684

Profound loss and senescence of adipose tissues are hallmarks of advanced age, but the underlying cause and their metabolic consequences remain obscure. Proper function of the murine double minute 2 (MDM2)–p53 axis is known to prevent tumorigenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03e325711897542011e839f66c205f1
https://doi.org/10.2337/db18-0684

Loss of Adipocyte MDM2 Causes Lipodystrophy by Inducing P53-Dependent Apoptosis and Senescence

Autor: Zhuohao Liu, Aimin Xu, Leigang Jin, Kenneth K.Y. Cheng, Baile Wang

Publikováno v: Diabetes. 67

Adipose tissue is crucial for the maintenance of metabolic health. Activation of tumor suppressor p53 is known to induce adipose tissue dysfunction and its related metabolic diseases in obesity and aging. Here we show that murine double minute 2 (MDM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51587c6cc67fde1f8d072dbb5b4fd870
https://doi.org/10.2337/db18-2027-p

Activation of hypothalamic RIP‐Cre neurons promotes beiging of WAT via sympathetic nervous system

Autor: Aimin Xu, Zhuohao Liu, Kenneth K.Y. Cheng, Ang Li, Xiaoqi Wang, Sonata S.Y. Yau, Xiaomu Li, Baile Wang, Kelvin K.L. Wu, Philip Wing-Lok Ho, Donghai Wu

Activation of brown adipose tissue (BAT) and beige fat by cold increases energy expenditure. Although their activation is known to be differentially regulated in part by hypothalamus, the underlying neural pathways and populations remain poorly chara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71aef64010a879d7d1e23640450efac7
https://europepmc.org/articles/PMC5891405/