Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Baikuntha Aryal"'
Autor:
Baikuntha Aryal, Joseph Tillotson, Kiwon Ok, Andrew T. Stoltzfus, Sarah L. J. Michel, V. Ashutosh Rao
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Pathogenesis of COVID-19 by SARS-CoV-2 resulted in a global pandemic and public health emergency in 2020. Viral infection can induce oxidative stress through reactive oxygen species (ROS). Inflammation and environmental stress are major sour
Externí odkaz:
https://doaj.org/article/8607a6785ee8427d8ba0c52ccb78da84
Autor:
Zephania Kwong Glover, Aaron Wecksler, Baikuntha Aryal, Shrenik Mehta, Melissa Pegues, Wayman Chan, Mari Lehtimaki, Allen Luo, Alavattam Sreedhara, V. Ashutosh Rao
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Biotherapeutics are exposed to common transition metal ions such as Cu(II) and Fe(II) during manufacturing processes and storage. IgG1 biotherapeutics are vulnerable to reactive oxygen species (ROS) generated via metal-catalyzed oxidation reactions.
Externí odkaz:
https://doaj.org/article/dc53b90652ca4eb487b24e5e38890be6
Autor:
Elliot Rosen, Dmitry Kryndushkin, Baikuntha Aryal, Yanira Gonzalez, Leena Chehab, Jennifer Dickey, V Ashutosh Rao
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233967 (2020)
Radiation-induced heart disease presents a significant challenge in the event of an accidental radiation exposure as well as to cancer patients who receive acute doses of irradiation as part of radiation therapy. We utilized the spontaneously hyperte
Externí odkaz:
https://doaj.org/article/852399ca289246bfb9b4a3422a6f3136
Autor:
Kaytee L. Pokrzywinski, Thomas G. Biel, Elliot T. Rosen, Julia L. Bonanno, Baikuntha Aryal, Francesca Mascia, Delaram Moshkelani, Steven Mog, V. Ashutosh Rao
Publikováno v:
Biology of Sex Differences, Vol 9, Iss 1, Pp 1-17 (2018)
Abstract Background Doxorubicin (DOX), an anthracycline therapeutic, is widely used to treat a variety of cancer types and known to induce cardiomyopathy in a time and dose-dependent manner. Postmenopausal and hypertensive females are two high-risk g
Externí odkaz:
https://doaj.org/article/e079b32ae31b427b80589dfdcb260e8d
Autor:
Baikuntha Aryal, V Ashutosh Rao
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194164 (2018)
Protein carbonylation is an irreversible post-translational modification induced by severe oxidative stress. Reactive oxygen species (ROS) are constantly produced in cells and play important roles in both cancer progression and cancer suppression. RO
Externí odkaz:
https://doaj.org/article/3e7da640e3dc44efbedd1f8283629ced
Autor:
Baikuntha Aryal, V Ashutosh Rao
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158376 (2016)
Cardiolipin (CL) is an inner mitochondrial membrane phospholipid which plays an important role in mitochondrial function. Perturbation in CL biosynthesis alters mitochondrial bioenergetics causing a severe genetic disorder commonly known as Barth syn
Externí odkaz:
https://doaj.org/article/ba880154c2bc4e5c8fea2ce3f0dff631
Autor:
Jennifer S Dickey, Yanira Gonzalez, Baikuntha Aryal, Steven Mog, Asako J Nakamura, Christophe E Redon, Ulrich Baxa, Elliot Rosen, Gang Cheng, Jacek Zielonka, Palak Parekh, Karen P Mason, Joy Joseph, Balaraman Kalyanaraman, William Bonner, Eugene Herman, Emily Shacter, V Ashutosh Rao
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70575 (2013)
Several front-line chemotherapeutics cause mitochondria-derived, oxidative stress-mediated cardiotoxicity. Iron chelators and other antioxidants have not completely succeeded in mitigating this effect. One hindrance to the development of cardioprotec
Externí odkaz:
https://doaj.org/article/7060670eeb5e44eba014664c9b3a8f2b
Publikováno v:
Biochemistry. 62:893-898
Autor:
Richard Pazdur, Gideon M. Blumenthal, Ann T. Farrell, Kirsten B. Goldberg, Steven Bowen, Christopher M. Sheth, Chao Liu, Ruby Leong, Yuan Li Shen, Donna Przepiorka, Rong Wang, Baikuntha Aryal, Natalie E. Simpson, Luning Zhuang, Liang Li, Xin Gao, Emily Y. Jen
Supplementary Table 1 contains FDA's screening algorithm for capillary leak syndrome (CLS).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ed8d0ff75dab154150f0380e96edf0
https://doi.org/10.1158/1078-0432.22476914.v1
https://doi.org/10.1158/1078-0432.22476914.v1
Autor:
Richard Pazdur, Gideon M. Blumenthal, Ann T. Farrell, Kirsten B. Goldberg, Steven Bowen, Christopher M. Sheth, Chao Liu, Ruby Leong, Yuan Li Shen, Donna Przepiorka, Rong Wang, Baikuntha Aryal, Natalie E. Simpson, Luning Zhuang, Liang Li, Xin Gao, Emily Y. Jen
Tagraxofusp-erzs (Elzonris, Stemline) is a cytotoxin that targets CD123-expressing cells. On December 21, 2018, FDA approved tagraxofusp-erzs for the treatment of blastic plasmacytoid dendritic cell neoplasms (BPDCN) in adult and pediatric patients 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4b2d8a53c69b4c65849d1eebfa9190
https://doi.org/10.1158/1078-0432.c.6529523
https://doi.org/10.1158/1078-0432.c.6529523