Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Baihua Hu"'
Autor:
Bryan K. Chan, Eileen Seward, Michael Lainchbury, Thomas F. Brewer, Le An, Toby Blench, Matthew W. Cartwright, Grace Ka Yan Chan, Edna F. Choo, Jason Drummond, Richard L. Elliott, Emanuela Gancia, Lewis Gazzard, Baihua Hu, Graham E. Jones, Xifeng Luo, Andrew Madin, Sushant Malhotra, John G. Moffat, Jodie Pang, Laurent Salphati, Christopher J. Sneeringer, Craig E. Stivala, Binqing Wei, Weiru Wang, Ping Wu, Timothy P. Heffron
Publikováno v:
ACS Med Chem Lett
[Image: see text] Hematopoietic progenitor kinase 1 (HPK1) is implicated as a negative regulator of T-cell receptor-induced T-cell activation. Studies using HPK1 kinase-dead knock-in animals have demonstrated the loss of HPK1 kinase activity resulted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f11f71008647153e48985266e826374
https://doi.org/10.1021/acsmedchemlett.1c00473
https://doi.org/10.1021/acsmedchemlett.1c00473
Autor:
Jun Chen, Baihua Hu, Kevin M. Johnson, Kang-Jye Chou, Jack A. Terrett, Yunli Wang, Lea Constantineau-Forget, Steven Magnuson, Chantal Grand-Maître, Francis Beaumier, John Liu, Lorena Riol-Blanco, Shannon D. Shields, Yong Chen, Brian Safina, Martin Dery, Elisia Villemure, Claudio Sturino, Huifen Chen, Luce Lépissier, Matthew Volgraf, Alessia Balestrini, Xiumin Wu, Daniel G. Shore, Stuart Ward, Wyne P. Lee, David H. Hackos, Andrew Peter Cridland, Robin Larouche-Gauthier, Lionel Rouge, Stephane Ciblat, Aijun Lu, Matt Baumgardner, Justin Ly, Rebecca M. Reese, Alexis Rohou, Eric Suto, Juan Zhang, Hank La
Publikováno v:
Journal of Medicinal Chemistry. 64:3843-3869
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium-permeable ion channel highly expressed in the primary sensory neurons functioning as a polymodal sensor for exogenous and endogenous stimuli and has generated widespread interes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17e5be6b310c8cbde93a6ecff3b6232
https://doi.org/10.1021/acs.jmedchem.0c02023
https://doi.org/10.1021/acs.jmedchem.0c02023
Autor:
Jun Chen, Justin Elstrott, Lan Wang, Simon S. Gao, Richard A.D. Carano, Jose E. Heredia, Elisia Villemure, Daniel G. Shore, Wyne P. Lee, Bobby Brillantes, Joseph H. Lin, Liling Liu, David H. Hackos, Jens Kortmann, Matthew Volgraf, Daniel D. Bravo, Christine Tam, Lorena Riol-Blanco, Steven Magnuson, Lionel Rouge, Chris Bjornson, Baihua Hu, Tania Chernov-Rogan, Rebecca M. Reese, Christopher P. Arthur, Min Jung, Michelle Dourado, Xiumin Wu, Victory Joseph, Alberto Estevez, John Liu, Alvin Gogineni, Juan Zhang, Laurie Leong, Jian Payandeh, Vishal Verma, Shannon D. Shields, Han Ting Ding, Brian Safina, Alessia Balestrini, Yong Chen, Vineela D. Gandham, Eric Suto, Jianyong Wang, Justin Ly, Rebecca N. Bauer, Jonas Doerr, Alexis Rohou, Cary D. Austin, Jason A. Vander Heiden, Xiaoying Yang, Ryan L. Wong, Lucinda Tam, Liuxi Chen, Kathy Hötzel, Kai H. Barck, Merone Roose-Girma, Claudio Ciferri, Huifen Chen, Bianca M. Liederer
Publikováno v:
Journal of Experimental Medicine. 218
Despite the development of effective therapies, a substantial proportion of asthmatics continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient receptor potential cation channel member A1 (TRPA1) agonists are elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7586a7b163f0274f73ff2d6634f422f1
https://doi.org/10.1084/jem.20201637
https://doi.org/10.1084/jem.20201637
Autor:
Chan, Bryan K., Seward, Eileen, Lainchbury, Michael, Brewer, Thomas F., Le An, Blench, Toby, Cartwright, Matthew W., Chan, Grace Ka Yan, Choo, Edna F., Drummond, Jason, Elliott, Richard L., Gancia, Emanuela, Gazzard, Lewis, Baihua Hu, Jones, Graham E., Xifeng Luo, Madin, Andrew, Malhotra, Sushant, Moffat, John G., Pang, Jodie
Publikováno v:
ACS Medicinal Chemistry Letters; 1/13/2022, Vol. 13 Issue 1, p84-91, 8p
Autor:
Rebecca M. Reese, Desiree Amm, Justin Ly, Aleksandr Kolesnikov, Christine E. Brotherton-Pleiss, Steven Do, Daniel G. Shore, David H. Hackos, Vishal Verma, Matthew Volgraf, Lesley J. Murray, Xiaofeng Xu, Guosheng Wu, Aijun Lu, Jun Chen, Baihua Hu, Martin E. Dahl, Huifen Chen, Yuen Po-Wai, Elisia Villemure, Yamin Zhang, Joseph P. Lyssikatos, Yong Chen, Brian Safina, Lan Wang, Anthony Estrada, Wienke Lange, Shawn David Erickson, Shannon D. Shields, Suzanne Tay
Publikováno v:
Journal of medicinal chemistry. 61(8)
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel expressed in sensory neurons where it functions as an irritant sensor for a plethora of electrophilic compounds and is implicated in pain, itch, and respiratory disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1efb169a4638458b259af0587c1a4d5
https://pubmed.ncbi.nlm.nih.gov/29590749
https://pubmed.ncbi.nlm.nih.gov/29590749
Autor:
Baihua Hu, Elaine Quinet, Irene Feingold, Igor Goljer, Thomas J. Berrodin, Mark J. Evans, James W Jetter, Jay Wrobel, Rayomand J. Unwalla, Michael D Basso, Annika Goos Nilsson, Anna Wilhelmsson
Publikováno v:
Journal of Medicinal Chemistry. 53:3296-3304
A series of phenyl sulfone substituted quinoxaline were prepared and the lead compound 13 (WYE-672) was shown to be a tissue selective LXR Agonist. Compound 13 demonstrated partial agonism for LXRbeta in kidney HEK-293 cells but did not activate Gal4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2418668e8e39d3a6194f3f8fbfab8dc3
https://doi.org/10.1021/jm100034x
https://doi.org/10.1021/jm100034x
Autor:
Baihua Hu, Rayomand J. Unwalla, Mark J. Evans, Jay E. Wrobel, Annika Goos-Nilsson, Anna Wilhelmsson, Michael D. Collini, Irene Feingold, Ron Bernotas, Ponnal Nambi, Elaine Quinet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:689-693
A series of quinoline-3-carboxamide containing sulfones was prepared and found to have good binding affinity for LXRbeta and moderate binding selectivity over LXRalpha. The 8-Cl quinoline analog 33 with a high TPSA score, displayed 34-fold binding se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8a4ec47fed1470799b19a5824da510
https://doi.org/10.1016/j.bmcl.2009.11.062
https://doi.org/10.1016/j.bmcl.2009.11.062
Autor:
Erik Wagner, Jonathan A. Bard, Kristine Svenson, Guixan Jin, Rajiv Chopra, Mei-Chu Lo, Minakshi Jani, Eric S. Manas, Pawel Nowak, Derek C. Cole, John W. Ellingboe, Baihua Hu, Robichaud Albert Jean, Kristi Fan, Michael S. Malamas, Rani Narasimhan, Jim Turner, Ann Aulabaugh, Ping Zhou, Rebecca Cowling, Steve Jacobsen, Peter H. Reinhart, Joseph Raymond Stock, Joan Subrath
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:632-635
8,8-Diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine (1) was identified through HTS, as a weak (micromolar) inhibitor of BACE1. X-Ray crystallographic studies indicate the 2-aminoimidazole ring forms key H-bonding interactions with Asp32 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f64763182d742185f38a6b59ffe4de0
https://doi.org/10.1016/j.bmcl.2009.11.052
https://doi.org/10.1016/j.bmcl.2009.11.052
Autor:
Elaine Quinet, Baihua Hu, Jay E. Wrobel, Anna Wihelmsson, Ponnal Nambi, Raymound Unwalla, Michael D. Collini, Annika Goos-Nilsson, Irene Feingold
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:3519-3527
A series of cinnolines/quinolines was prepared and it was found that 4-phenyl-cinnoline/quinolines with either a 2',3' or 2',5'-disubstituted benzyloxy moiety or the 1-Me-7-indole methoxy moiety on the meta position of the 4-phenyl ring showed good b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf31f7116c047da01138df80c4ce11e8
https://doi.org/10.1016/j.bmc.2009.04.012
https://doi.org/10.1016/j.bmc.2009.04.012
Autor:
Charles Eigenbrot, Yong Chen, Xiaofeng Xu, Daniel F. Ortwine, Paul A. McEwan, Claire Ellebrandt, Zhonghua Lin, Daniel Kordt, Yamin Zhang, Daniel B. Stein, Baihua Hu, Richard Goldsmith, Ali A. Zarrin, John Barker, Xiaolu Wang, Jason DeVoss, Yuen Po-Wai, Jason Burch, M. Hicham A. Ismaili, Kevin Lau, Kathy Barrett, Yuan Chen, Zhonghua Pei
Publikováno v:
Journal of medicinal chemistry. 58(9)
The medicinal chemistry community has directed considerable efforts toward the discovery of selective inhibitors of interleukin-2 inducible T-cell kinase (ITK), given its role in T-cell signaling downstream of the T-cell receptor (TCR) and the implic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af042a664b1539fc20b020da84768b01
https://pubmed.ncbi.nlm.nih.gov/25844760
https://pubmed.ncbi.nlm.nih.gov/25844760