Host engineering for improved valerolactam production inPseudomonas putida

Autor: Jay D. Keasling, Yan Chen, Baidoo Eek, Jacquelyn M. Blake-Hedges, Christopher J. Petzold, Mitchell G. Thompson, Adam M. Deutschbauer, Sermeno Ln, Allison N. Pearson, Pablo Cruz-Morales, Velasquez Ae, William A. Sharpless, Veronica T. Benites, Luis E. Valencia

Pseudomonas putidais a promising bacterial chassis for metabolic engineering given its ability to metabolize a wide array of carbon sources, especially aromatic compounds derived from lignin. However, this omnivorous metabolism can also be a hindranc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643abb8075bf141eaac7bddb36fb5452
https://doi.org/10.1101/660795

Biochemical Characterization of β-Amino Acid Incorporation in FluvirucinB2Biosynthesis

Autor: Barajas, JF, Zargar, A, Pang, B, Benites, VT, Gin, J, Baidoo, EEK, Petzold, CJ, Hillson, NJ, Keasling, JD

Publikováno v: Barajas, JF; Zargar, A; Pang, B; Benites, VT; Gin, J; Baidoo, EEK; et al.(2018). Biochemical Characterization of β-Amino Acid Incorporation in FluvirucinB2Biosynthesis. ChemBioChem. doi: 10.1002/cbic.201800169. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/71d5d5kn

© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Naturally occurring lactams, such as the polyketide-derived macrolactams, provide a diverse class of natural products that could enhance existing chemically produced lactams. Although β-amino acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::e616230f97f56f8670152fdc86348ee7
http://www.escholarship.org/uc/item/71d5d5kn

Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type i Modular Polyketide Synthase Subunit

Autor: Eng, CH, Yuzawa, S, Wang, G, Baidoo, EEK, Katz, L, Keasling, JD

Publikováno v: Eng, CH; Yuzawa, S; Wang, G; Baidoo, EEK; Katz, L; & Keasling, JD. (2016). Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type i Modular Polyketide Synthase Subunit. Biochemistry, 55(12), 1677-1680. doi: 10.1021/acs.biochem.6b00129. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/5zw6k4dm

© 2016 American Chemical Society. Polyketide natural products have broad applications in medicine. Exploiting the modular nature of polyketide synthases to alter stereospecificity is an attractive strategy for obtaining natural product analogues wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::4bb993fa188e1cc2211acc487ec9eeff
http://www.escholarship.org/uc/item/5zw6k4dm

Acute Limonene Toxicity in Escherichia coli Is Caused by Limonene Hydroperoxide and Alleviated by a Point Mutation in Alkyl Hydroperoxidase AhpC

Autor: Chubukov, V, Mingardon, F, Schackwitz, W, Baidoo, EEK, Alonso-Gutierrez, J, Hu, Q, Lee, TS, Keasling, JD, Mukhopadhyay, A

Publikováno v: Applied and environmental microbiology, vol 81, iss 14
Chubukov, V; Mingardon, F; Schackwitz, W; Baidoo, EEK; Alonso-Gutierrez, J; Hu, Q; et al.(2015). Acute limonene toxicity in Escherichia coli is caused by limonene hydroperoxide and alleviated by a point mutation in alkyl hydroperoxidase AhpC. Applied and Environmental Microbiology, 81(14), 4690-4696. doi: 10.1128/AEM.01102-15. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/37b8d8s5

© 2015, American Society for Microbiology. Limonene, a major component of citrus peel oil, has a number of applications related to microbiology. The antimicrobial properties of limonene make it a popular disinfectant and food preservative, while its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f7cd4f3bfb40f81dcc9865d4782d0807
https://escholarship.org/uc/item/37b8d8s5

Engineered reduction of S-adenosylmethionine alters lignin in sorghum.

Autor: Tian Y; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 978R4468, Berkeley, CA, 94720, USA., Gao Y; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 978R4468, Berkeley, CA, 94720, USA., Turumtay H; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 978R4468, Berkeley, CA, 94720, USA.; Department of Energy System Engineering, Karadeniz Technical University, 61830, Trabzon, Turkey., Turumtay EA; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 978R4468, Berkeley, CA, 94720, USA.; Department of Chemistry, Recep Tayyip Erdogan University, 53100, Rize, Turkey., Chai YN; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 978R4468, Berkeley, CA, 94720, USA., Choudhary H; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; Department of Bioresource and Environmental Security, Sandia National Laboratories, Livermore, CA, 94550, USA., Park JH; Forage Genetics International, West Salem, WI, 54669, USA., Wu CY; Forage Genetics International, West Salem, WI, 54669, USA., De Ben CM; Department of Plant Sciences, University of California-Davis, Davis, CA, 95616, USA., Dalton J; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 978R4468, Berkeley, CA, 94720, USA., Louie KB; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 978R4468, Berkeley, CA, 94720, USA.; Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Harwood T; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 978R4468, Berkeley, CA, 94720, USA.; Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Chin D; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; Rausser College of Natural Resources, University of California-Berkeley, Berkeley, CA, 94720, USA., Vuu KM; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 978R4468, Berkeley, CA, 94720, USA., Bowen BP; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 978R4468, Berkeley, CA, 94720, USA.; Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Shih PM; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 978R4468, Berkeley, CA, 94720, USA.; Department of Plant and Microbial Biology, University of California-Berkeley, Berkeley, CA, 94720, USA., Baidoo EEK; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Northen TR; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 978R4468, Berkeley, CA, 94720, USA.; Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Simmons BA; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Hutmacher R; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; University of California, Agriculture and Natural Resources, Kearney Agricultural Research and Extension Center, Parlier, CA, 93648, USA., Atim J; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; University of California, Agriculture and Natural Resources, Kearney Agricultural Research and Extension Center, Parlier, CA, 93648, USA., Putnam DH; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; Department of Plant Sciences, University of California-Davis, Davis, CA, 95616, USA., Scown CD; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.; Energy & Biosciences Institute, University of California-Berkeley, Berkeley, CA, 94720, USA.; Energy Analysis and Environmental Impacts Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Mortimer JC; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 978R4468, Berkeley, CA, 94720, USA.; School of Agriculture, Food, and Wine, University of Adelaide, Glen Osmond, South Australia, Australia., Scheller HV; Joint BioEnergy Institute, Emeryville, CA, 94608, USA.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 978R4468, Berkeley, CA, 94720, USA.; Department of Plant and Microbial Biology, University of California-Berkeley, Berkeley, CA, 94720, USA., Eudes A; Joint BioEnergy Institute, Emeryville, CA, 94608, USA. ageudes@lbl.gov.; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 978R4468, Berkeley, CA, 94720, USA. ageudes@lbl.gov.

Publikováno v: Biotechnology for biofuels and bioproducts [Biotechnol Biofuels Bioprod] 2024 Oct 15; Vol. 17 (1), pp. 128. Date of Electronic Publication: 2024 Oct 15.