Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Bai-Yu Lee"'
Autor:
Xubin Zheng, Xuwei Gui, Lan Yao, Jun Ma, Yifan He, Hai Lou, Jin Gu, Ruoyan Ying, Liping Chen, Qin Sun, Yidian Liu, Chih-Ming Ho, Bai-Yu Lee, Daniel L. Clemens, Marcus A. Horwitz, Xianting Ding, Xiaohui Hao, Hua Yang, Wei Sha
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 1 (2023)
ABSTRACTIn preclinical studies, a new antituberculosis drug regimen markedly reduced the time required to achieve relapse-free cure. This study aimed to preliminarily evaluate the efficacy and safety of this four-month regimen, consisting of clofazim
Externí odkaz:
https://doaj.org/article/bcc7bcb8469149d9a4e7a3b5d77c9834
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Francisella tularensis, a Tier 1 select agent of bioterrorism, contains a type VI secretion system (T6SS) encoded within the Francisella pathogenicity island (FPI), which is critical for its pathogenesis. Among the 18 proteins encoded by FPI
Externí odkaz:
https://doaj.org/article/81629bbcb0ca46dfbb412f4c661d3273
Autor:
Bai-Yu Lee, Daniel L. Clemens, Aleidy Silva, Barbara Jane Dillon, Saša Masleša-Galić, Susana Nava, Xianting Ding, Chih-Ming Ho, Marcus A. Horwitz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Current antibiotic therapies for tuberculosis are lengthy and onerous. Here, the authors use an output-driven approach to optimize drug doses for two experimental drug regimens in a mouse model of tuberculosis, leading to improved regimens that reduc
Externí odkaz:
https://doaj.org/article/589689ebb4e6419f8418ee3376f93d87
Autor:
Daniel L Clemens, Bai-Yu Lee, Aleidy Silva, Barbara Jane Dillon, Saša Masleša-Galić, Susana Nava, Xianting Ding, Chih-Ming Ho, Marcus A Horwitz
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0215607 (2019)
BackgroundShorter, more effective treatments for tuberculosis (TB) are urgently needed. While many TB drugs are available, identification of the best regimens is challenging because of the large number of possible drug-dose combinations. We have foun
Externí odkaz:
https://doaj.org/article/cde177d439264af188ccfb9b5f5493d9
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Francisella tularensisis subsp. tularensis is an intracellular bacterial pathogen and the causative agent of the life-threatening zoonotic disease tularemia. The Francisella Pathogenicity Island encodes a large secretion apparatus, known as a Type VI
Externí odkaz:
https://doaj.org/article/9bc9d992c9a44979a1189f07f97c3768
Autor:
Bai-Yu Lee, Daniel L Clemens, Aleidy Silva, Barbara Jane Dillon, Saša Masleša-Galić, Susana Nava, Chih-Ming Ho, Marcus A Horwitz
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207469 (2018)
As current treatment of tuberculosis is burdensomely long, provoking non-adherence and drug resistance, effective short-course treatments are needed. Using the output-driven parabolic response surface (PRS) platform, we have identified drug regimens
Externí odkaz:
https://doaj.org/article/5b99654f36db4e2abf60fb0fc1538cb4
Autor:
Tingyi Leo Liu, Pei-Shan Chung, Daniel L. Clemens, Jason S. Hong, Michael A. Teitell, Tianxing Man, Pei-Yu Chiou, Bai-Yu Lee, Chuanzhen Zhao, Cong Wu, Yu Ting Chow, Alexander N. Patananan, Paul S. Weiss, Xiongfeng Zhu, Ximiao Wen, Emma R. Dawson
Publikováno v:
ACS Nano. 13:10835-10844
Efficient intracellular delivery of biomolecules into cells that grow in suspension is of great interest for biomedical research, such as for applications in cancer immunotherapy. Although tremendous effort has been expended, it remains challenging f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3bd63debdc1ec68c00f7f424727679f
https://doi.org/10.1021/acsnano.9b06025
https://doi.org/10.1021/acsnano.9b06025
Autor:
Marcus A. Horwitz, Chia-Jung Yu, Jeffrey I. Zink, Michael V. Tullius, Sheba Plamthottam, Zilu Li, Bai-Yu Lee, Barbara Jane Dillon, Ruining Wang, Daniel L. Clemens
Publikováno v:
ACS Infectious Diseases. 5:281-291
Francisella tularensis causes a serious and often fatal infection, tularemia. We compared the efficacy of moxifloxacin formulated as free drug vs disulfide snap-top mesoporous silica nanoparticles (MSNs) in a mouse model of pneumonic tularemia. We fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80d798ac8387b353537841d8d7ba7c0
https://doi.org/10.1021/acsinfecdis.8b00268
https://doi.org/10.1021/acsinfecdis.8b00268
Publikováno v:
Journal of the American Chemical Society. 139:6663-6668
We present a synthetic approach to a highly pathogen-selective detection and delivery platform based on the interaction of an antibody nanovalve with a tetrasaccharide from the O-antigen of the lipopolysaccharide (LPS) of Francisella tularensis bacte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5fc1301372b90fd7e93a0bcce93d16b
https://doi.org/10.1021/jacs.7b01278
https://doi.org/10.1021/jacs.7b01278
Publikováno v:
Advanced Therapeutics
Tuberculosis (TB) is a major health problem that causes more deaths worldwide than any other single infectious disease. Current multidrug therapy for tuberculosis is exceedingly lengthy, leading to poor drug adherence, and consequently the emergence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db71546fddc5f38c90f92f8d63257a2f
http://europepmc.org/articles/PMC6988120
http://europepmc.org/articles/PMC6988120