Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Bahram Resul"'
Autor:
Hisashi Doi, Masaaki Suzuki, Margareta Björkman, Ryoji Noyori, Yasuyoshi Watanabe, Bengt Långström, Bahram Resul
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 43:1327-1334
17-(3-[11C]methylphenyl)-18,19,20-trinor-PGF2αisopropyl ester 2 was synthesised using an improved method for cross-coupling reactions with [11C]methyl iodide. The decay-corrected radiochemical yield of 2 was 34 % based on [11C]methyl iodide in a syn
Publikováno v:
Journal of Medicinal Chemistry. 38:289-304
The 15R and 15S epimers of a series of phenyl substituted analogs of 17-phenyl-18,19,20-trinorprostaglandin F2 alpha isopropyl ester [(15S)-3] have been synthesized. The intraocular pressure (IOP) lowering effects and potential side effects of these
Autor:
Albert Alm, Anders Marsk, Johan Stjernschantz, Anja Tuulonen, Agneta Mandahl, Juhani P. Airaksinen, Jörgen Villumsen, Per Törnquist, Bahram Resul
Publikováno v:
Ophthalmology. 100:1312-1317
Purpose: To establish the dose-response relationship for the effect on intraocular pressure (IOP) and side effects during long-term treatment of patients with ocular hypertension with the prostaglandin F 2α (PGF 2α ) analog PhXA41. Methods: A three
Palladium catalyzed syntheses of phenyl-substittuted pgf2α analogues: potential antigluaucoma agents
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:241-244
A PGF 2α -isopropylester derivative with a modified ω-chain containing a phenyl group ( 1 ) is an interesting antiglaucoma agent. Herein we described a synthetic strategy which provides an arrays of derivatives of 1 by use of palladium catalyzed me
Publikováno v:
ChemInform. 26
Publikováno v:
ChemInform. 27
Novel prostaglandin F2α derivatives, functionalized at C13 and C14, have been prepared. 17-Phenyl-18,19,20-trinorprostaglandin F2α isopropyl ester [(15S)-1] and its epimer [(15R)-1] were stereoselectively epoxidized, using Sharpless conditions, to
Autor:
K. N. Houk, Daniel R. Carcanague, Markku R. Sundberg, Reijo Sillanpää, Johan Stjernschantz, Milan M. Jakšić, Bahram Resul, Ito Chao
Publikováno v:
Acta Chemica Scandinavica. 46:34-37
Publikováno v:
Progress in retinal and eye research. 19(4)
Prostaglandin F(2alpha) analogues have recently been introduced on the market for glaucoma treatment. While these drugs have a well-documented intraocular pressure reducing effect only a limited number of studies have been published regarding their e
Publikováno v:
Survey of ophthalmology. 41
Latanoprost, a new ocular hypotensive prostaglandin F2 alpha analogue prodrug, was found to induce increased pigmentation of monkey irides in chronic toxicity studies. This prompted us to investigate the effect of naturally occurring prostaglandins o
Publikováno v:
The Journal of organic chemistry. 61(12)
Novel prostaglandin F(2)(alpha) derivatives, functionalized at C13 and C14, have been prepared. 17-Phenyl-18,19,20-trinorprostaglandin F(2)(alpha) isopropyl ester [(15S)-1] and its epimer [(15R)-1] were stereoselectively epoxidized, using Sharpless c