Moderate Folic Acid Supplementation in Pregnant Mice Results in Behavioral Alterations in Offspring with Sex-Specific Changes in Methyl Metabolism.

Autor: Cosín-Tomás M; Departments of Human Genetics and Pediatrics, Research Institute of the McGill University Health Center, McGill University, Montreal, QC H4A 3J1, Canada., Luan Y; Departments of Human Genetics and Pediatrics, Research Institute of the McGill University Health Center, McGill University, Montreal, QC H4A 3J1, Canada., Leclerc D; Departments of Human Genetics and Pediatrics, Research Institute of the McGill University Health Center, McGill University, Montreal, QC H4A 3J1, Canada., Malysheva OV; Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY 14853, USA., Lauzon N; Drug Discovery Platform, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada., Bahous RH; Departments of Human Genetics and Pediatrics, Research Institute of the McGill University Health Center, McGill University, Montreal, QC H4A 3J1, Canada., Christensen KE; Departments of Human Genetics and Pediatrics, Research Institute of the McGill University Health Center, McGill University, Montreal, QC H4A 3J1, Canada., Caudill MA; Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY 14853, USA., Rozen R; Departments of Human Genetics and Pediatrics, Research Institute of the McGill University Health Center, McGill University, Montreal, QC H4A 3J1, Canada.

Publikováno v: Nutrients [Nutrients] 2020 Jun 08; Vol. 12 (6). Date of Electronic Publication: 2020 Jun 08.

Mild Methylenetetrahydrofolate Reductase Deficiency Alters Inflammatory and Lipid Pathways in Liver.

Autor: Leclerc D; Departments of Human Genetics and Pediatrics, McGill University, McGill University Health Center (MUHC), Montreal, H4A 3J1, Canada., Christensen KE; Departments of Human Genetics and Pediatrics, McGill University, McGill University Health Center (MUHC), Montreal, H4A 3J1, Canada., Cauvi O; Departments of Human Genetics and Pediatrics, McGill University, McGill University Health Center (MUHC), Montreal, H4A 3J1, Canada., Yang E; Department of Chemistry, Université de Montréal, Montreal, H3T 1J4, Canada., Fournelle F; Department of Chemistry, Université de Montréal, Montreal, H3T 1J4, Canada., Bahous RH; Departments of Human Genetics and Pediatrics, McGill University, McGill University Health Center (MUHC), Montreal, H4A 3J1, Canada., Malysheva OV; Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY, 14853, USA., Deng L; Departments of Human Genetics and Pediatrics, McGill University, McGill University Health Center (MUHC), Montreal, H4A 3J1, Canada., Wu Q; Departments of Human Genetics and Pediatrics, McGill University, McGill University Health Center (MUHC), Montreal, H4A 3J1, Canada., Zhou Z; Departments of Human Genetics and Pediatrics, McGill University, McGill University Health Center (MUHC), Montreal, H4A 3J1, Canada., Gao ZH; Department of Pathology, McGill University, Montreal, H4A 3J1, Canada., Chaurand P; Department of Chemistry, Université de Montréal, Montreal, H3T 1J4, Canada., Caudill MA; Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY, 14853, USA., Rozen R; Departments of Human Genetics and Pediatrics, McGill University, McGill University Health Center (MUHC), Montreal, H4A 3J1, Canada.

Publikováno v: Molecular nutrition & food research [Mol Nutr Food Res] 2019 Feb; Vol. 63 (3), pp. e1801001. Date of Electronic Publication: 2018 Nov 23.

High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.

Autor: Bahous RH; Departments of Human Genetics and Pediatrics, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada., Jadavji NM; Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada., Deng L; Departments of Human Genetics and Pediatrics, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada., Cosín-Tomás M; Pharmacology Unit, Faculty of Pharmacy, Institut de Neurociència Universitat de Barcelona (IBUB), Nucli Universitari de Pedralbes, Barcelona, Spain., Lu J; Departments of Human Genetics and Pediatrics, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada., Malysheva O; Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY, USA., Leung KY; Developmental Biology and Cancer Programme, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Ho MK; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Pallàs M; Pharmacology Unit, Faculty of Pharmacy, Institut de Neurociència Universitat de Barcelona (IBUB), Nucli Universitari de Pedralbes, Barcelona, Spain., Kaliman P; Institute of Biomedical Investigation of Barcelona, Spanish National Research Council, Barcelona, Spain.; Center for Mind and Brain, University of California Davis, Davis, CA, USA., Greene NDE; Developmental Biology and Cancer Programme, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Bedell BJ; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Caudill MA; Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY, USA., Rozen R; Departments of Human Genetics and Pediatrics, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2017 Mar 01; Vol. 26 (5), pp. 888-900.

MTHFD1 formyltetrahydrofolate synthetase deficiency, a model for the MTHFD1 R653Q variant, leads to congenital heart defects in mice.

Autor: Christensen KE; Departments of Human Genetics and Pediatrics, McGill University, and the Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada., Deng L; Departments of Human Genetics and Pediatrics, McGill University, and the Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada., Bahous RH; Departments of Human Genetics and Pediatrics, McGill University, and the Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada., Jerome-Majewska LA; Departments of Human Genetics and Pediatrics, McGill University, and the Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada., Rozen R; Departments of Human Genetics and Pediatrics, McGill University, and the Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.

Publikováno v: Birth defects research. Part A, Clinical and molecular teratology [Birth Defects Res A Clin Mol Teratol] 2015 Dec; Vol. 103 (12), pp. 1031-8. Date of Electronic Publication: 2015 Sep 26.

Mouse model for deficiency of methionine synthase reductase exhibits short-term memory impairment and disturbances in brain choline metabolism.

Autor: Jadavji NM; Departments of Human Genetics and Pediatrics, McGill University, Montreal Children's Hospital site of the McGill University Health Centre Research Institute, 4060 Ste. Catherine St. West, Montreal, Quebec, Canada, H3Z 2Z3., Bahous RH; Departments of Human Genetics and Pediatrics, McGill University, Montreal Children's Hospital site of the McGill University Health Centre Research Institute, 4060 Ste. Catherine St. West, Montreal, Quebec, Canada, H3Z 2Z3., Deng L; Departments of Human Genetics and Pediatrics, McGill University, Montreal Children's Hospital site of the McGill University Health Centre Research Institute, 4060 Ste. Catherine St. West, Montreal, Quebec, Canada, H3Z 2Z3., Malysheva O; †Division of Nutritional Sciences, Cornell University, 241 Kinzelberg Hall, Ithaca, NY 14853 6300, U.S.A., Grand'maison M; ‡Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, 3801 University Street, Montreal, Quebec, Canada, H3A 2B4., Bedell BJ; ‡Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, 3801 University Street, Montreal, Quebec, Canada, H3A 2B4., Caudill MA; †Division of Nutritional Sciences, Cornell University, 241 Kinzelberg Hall, Ithaca, NY 14853 6300, U.S.A., Rozen R; Departments of Human Genetics and Pediatrics, McGill University, Montreal Children's Hospital site of the McGill University Health Centre Research Institute, 4060 Ste. Catherine St. West, Montreal, Quebec, Canada, H3Z 2Z3.

Publikováno v: The Biochemical journal [Biochem J] 2014 Jul 15; Vol. 461 (2), pp. 205-12.