Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development

Autor: Christensen, Karen E, Hou, Wenyang, Bahous, Renata H, Deng, Liyuan, Malysheva, Olga V, Arning, Erland, Bottiglieri, Teodoro, Caudill, Marie A, Jerome-Majewska, Loydie A, Rozen, Rima ^*

Publikováno v: In The American Journal of Clinical Nutrition November 2016 104(5):1459-1469

High Dietary Folate in Mice Alters Immune Response and Reduces Survival after Malarial Infection.

Autor: Meadows, Danielle N.¹, Bahous, Renata H.¹, Best, Ana F.², Rozen, Rima^1,3 rima.rozen@mcgill.ca

Publikováno v: PLoS ONE. 11/24/2015, Vol. 10 Issue 11, p1-17. 17p.

High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring

Autor: Bahous, Renata H., Jadavji, Nafisa M., Deng, Liyuan, Cosín-Tomás, Marta, Lu, Jessica, Malysheva, Olga, Leung, Kit-Yi, Ho, Ming-Kai, Pallàs, Mercè, Kaliman, Perla, Greene, Nicholas D.E., Caudill, Marie A., Rozen, Rima

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Methylenetetrahydrofolate reductase (MTHFR) generates methyltetrahydrofolate for methylation reactions. Severe MTHFR deficiency results in homocystinuria and neurologic impairment. Mild MTHFR deficiency (677C > T polymorphism) increases risk for comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a4d33142c65bc8c949977ce3a0e28c07
http://hdl.handle.net/10261/176556

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High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.

Autor: Bahous RH; Departments of Human Genetics and Pediatrics, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada., Jadavji NM; Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada., Deng L; Departments of Human Genetics and Pediatrics, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada., Cosín-Tomás M; Pharmacology Unit, Faculty of Pharmacy, Institut de Neurociència Universitat de Barcelona (IBUB), Nucli Universitari de Pedralbes, Barcelona, Spain., Lu J; Departments of Human Genetics and Pediatrics, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada., Malysheva O; Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY, USA., Leung KY; Developmental Biology and Cancer Programme, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Ho MK; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Pallàs M; Pharmacology Unit, Faculty of Pharmacy, Institut de Neurociència Universitat de Barcelona (IBUB), Nucli Universitari de Pedralbes, Barcelona, Spain., Kaliman P; Institute of Biomedical Investigation of Barcelona, Spanish National Research Council, Barcelona, Spain.; Center for Mind and Brain, University of California Davis, Davis, CA, USA., Greene NDE; Developmental Biology and Cancer Programme, Great Ormond Street Institute of Child Health, University College London, London, United Kingdom., Bedell BJ; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Caudill MA; Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY, USA., Rozen R; Departments of Human Genetics and Pediatrics, Research Institute of the McGill University Health Center, Montreal, Quebec, Canada.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2017 Mar 01; Vol. 26 (5), pp. 888-900.