Polytrauma impairs fracture healing accompanied by increased persistence of innate inflammatory stimuli and reduced adaptive response.

Autor: Saiz AM; Department of Orthopaedic Surgery, UC Davis Health, Sacramento, California, USA., Rahmati M; Department of Orthopaedic Surgery, UC Davis Health, Sacramento, California, USA., Gresham RCH; Department of Orthopaedic Surgery, UC Davis Health, Sacramento, California, USA., Baldini TD; Department of Orthopaedic Surgery, UC Davis Health, Sacramento, California, USA.; California Northstate University College of Medicine, Sacramento, California, USA., Burgan J; Department of Orthopaedic Surgery, UC Davis Health, Sacramento, California, USA.; Stony Brook Renaissance School of Medicine, Stony Brook, New York, USA., Lee MA; Department of Orthopaedic Surgery, UC Davis Health, Sacramento, California, USA., Osipov B; Department of Orthopaedic Surgery, UC Davis Health, Sacramento, California, USA., Christiansen BA; Department of Orthopaedic Surgery, UC Davis Health, Sacramento, California, USA., Khassawna TE; Experimental Trauma Surgery, Justus-Liebig University Giessen, Giessen, Germany.; Faculty of Health Sciences, University of Applied Sciences, Giessen, Germany., Wieland DCF; Institute of Metallic Biomaterials, Helmholtz Zentrum Hereon, Geesthacht, Germany., Marinho AL; Institute of Metallic Biomaterials, Helmholtz Zentrum Hereon, Geesthacht, Germany., Blanchet C; European Molecular Biology Laboratory EMBL, Hamburg, Germany., Czachor M; Steadman Phillippon Research Institute, Vail, Colorado, USA., Working ZM; Oregon Health Sciences University, Portland, Oregon, USA., Bahney CS; Steadman Phillippon Research Institute, Vail, Colorado, USA.; University of California, San Francisco, California, USA., Leach JK; Department of Orthopaedic Surgery, UC Davis Health, Sacramento, California, USA.

Publikováno v: Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2024 Nov 17. Date of Electronic Publication: 2024 Nov 17.

Clinical validation of C 12 FDG as a marker associated with senescence and osteoarthritic phenotypes.

Autor: Hambright WS; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Duke VR; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Goff AD; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Goff AW; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Minas LT; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Kloser H; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Gao X; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Huard C; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Guo P; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Lu A; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Mitchell J; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Mullen M; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Su C; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Tchkonia T; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA., Espindola Netto JM; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA., Robbins PD; Department of Biochemistry and Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA., Niedernhofer LJ; Department of Biochemistry and Molecular Biology and Biophysics, Institute on the Biology of Aging and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA., Kirkland JL; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.; Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA., Bahney CS; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA.; Orthopaedic Trauma Institute, University of California San Francisco, San Francisco, California, USA., Philippon M; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA.; The Steadman Clinic, Vail, Colorado, USA., Huard J; Center for Regenerative Sports Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA.

Publikováno v: Aging cell [Aging Cell] 2024 May; Vol. 23 (5), pp. e14113. Date of Electronic Publication: 2024 May 06.

Evaluating the Morphology of Unique Superficial Fissured Cartilage Lesions at the Femoral Head-Neck Junction in Patients with Femoroacetabular Impingement Syndrome.

Autor: Yamaura K; Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA.; Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan., Nishimura H; Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Ruzbarsky JJ; Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA.; The Steadman Clinic, Vail, Colorado, USA., Kuhns BD; Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA.; The Steadman Clinic, Vail, Colorado, USA., Mullen MT; Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Duke VR; Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., O'Hara KM; Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Brown JM; Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Comfort SM; Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Hambright WS; Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Bahney CS; Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA.; The Orthopaedic Trauma Institute, University of California, San Francisco (UCSF), San Francisco, California, USA., Huard J; Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA., Philippon MJ; Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, Colorado, USA.; The Steadman Clinic, Vail, Colorado, USA.

Publikováno v: Orthopaedic journal of sports medicine [Orthop J Sports Med] 2024 Feb 08; Vol. 12 (2), pp. 23259671231219217. Date of Electronic Publication: 2024 Feb 08 (Print Publication: 2024).

Encapsulation of β-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair.

Autor: Rivera KO; Graduate Program in Oral and Craniofacial Sciences, School of Dentistry, University of California, San Francisco (UCSF), San Francisco, CA, United States.; Department of Orthopaedic Surgery, Orthopaedic Trauma Institute, University of California, San Francisco (UCSF), San Francisco, CA, United States.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco (UCSF), San Francisco, CA, United States., Cuylear DL; Graduate Program in Oral and Craniofacial Sciences, School of Dentistry, University of California, San Francisco (UCSF), San Francisco, CA, United States.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco (UCSF), San Francisco, CA, United States., Duke VR; Center for Regenerative and Personalized Medicine, The Steadman Philippon Research Institute (SPRI), Vail, CO, United States., O'Hara KM; Center for Regenerative and Personalized Medicine, The Steadman Philippon Research Institute (SPRI), Vail, CO, United States., Zhong JX; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco (UCSF), San Francisco, CA, United States.; UC Berkeley-UCSF Graduate Program in Bioengineering, San Francisco, CA, United States., Elghazali NA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco (UCSF), San Francisco, CA, United States.; UC Berkeley-UCSF Graduate Program in Bioengineering, San Francisco, CA, United States., Finbloom JA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco (UCSF), San Francisco, CA, United States., Kharbikar BN; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco (UCSF), San Francisco, CA, United States., Kryger AN; School of Dentistry, University of California, San Francisco (UCSF), San Francisco, CA, United States., Miclau T; Department of Orthopaedic Surgery, Orthopaedic Trauma Institute, University of California, San Francisco (UCSF), San Francisco, CA, United States., Marcucio RS; Department of Orthopaedic Surgery, Orthopaedic Trauma Institute, University of California, San Francisco (UCSF), San Francisco, CA, United States., Bahney CS; Graduate Program in Oral and Craniofacial Sciences, School of Dentistry, University of California, San Francisco (UCSF), San Francisco, CA, United States.; Department of Orthopaedic Surgery, Orthopaedic Trauma Institute, University of California, San Francisco (UCSF), San Francisco, CA, United States.; Center for Regenerative and Personalized Medicine, The Steadman Philippon Research Institute (SPRI), Vail, CO, United States.; UC Berkeley-UCSF Graduate Program in Bioengineering, San Francisco, CA, United States., Desai TA; Graduate Program in Oral and Craniofacial Sciences, School of Dentistry, University of California, San Francisco (UCSF), San Francisco, CA, United States.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco (UCSF), San Francisco, CA, United States.; Department of Bioengineering, University of California, Berkeley (UC Berkeley), Berkeley, CA, United States.; School of Engineering, Brown University, Providence, RI, United States.

Publikováno v: Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2023 May 22; Vol. 11, pp. 1190371. Date of Electronic Publication: 2023 May 22 (Print Publication: 2023).

Cellular expansion of MSCs: Shifting the regenerative potential.

Autor: Miclau K; Center for Regenerative and Personalized Medicine (CRPM), Steadman Philippon Research Institute, Vail, Colorado, USA.; Orthopaedic Trauma Institute (OTI), University of California San Francisco, San Francisco, California, USA., Hambright WS; Center for Regenerative and Personalized Medicine (CRPM), Steadman Philippon Research Institute, Vail, Colorado, USA., Huard J; Center for Regenerative and Personalized Medicine (CRPM), Steadman Philippon Research Institute, Vail, Colorado, USA., Stoddart MJ; Orthopaedic Trauma Institute (OTI), University of California San Francisco, San Francisco, California, USA., Bahney CS; Center for Regenerative and Personalized Medicine (CRPM), Steadman Philippon Research Institute, Vail, Colorado, USA.; AO Research Institute Davos, Davos, Switzerland.

Publikováno v: Aging cell [Aging Cell] 2023 Jan; Vol. 22 (1), pp. e13759. Date of Electronic Publication: 2022 Dec 19.