Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Bahige Baroudy"'
Autor:
Mahesh J. Patel, † Tze-Ming Chan, Bahige Baroudy, Joseph Terracciano, Mohindar S. Puar, Min Chu, Nicole Wagner, Vincent P. Gullo, and Andrew T. McPhail, Ronald Mierzwa, † Shu-Wei Yang
Publikováno v:
Journal of Natural Products. 69:1025-1028
Two novel chemokine receptor CCR-5 inhibitors, Sch 210971 (1) and Sch 210972 (2), were isolated from the fungal fermentation broth of Chaetomium globosum by normal- and reversed-phase HPLC purifications. The structure determination of 1 and 2 was acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981babedf62bec9c0d4c3814edb45b29
https://doi.org/10.1021/np060121y
https://doi.org/10.1021/np060121y
Autor:
Odile E. Levy, Susan Y. Tamura, Andrew Prongay, Robert Chase, Sumei Ruan, Rong Liu, Bahige Baroudy, Paul Ingravallo, Kemp Scott Jeffrey, Viyyoor Girijavallabhan, Kevin Chen, John Pichardo, Bennett Frank, Tony Y. Hsieh, F. George Njoroge, Weidong Pan, Raymond G. Lovey, Kuo-Chi Cheng, Ashok Arasappan, Edwin Jao, Lim-Wilby Marguerita, Jean-Marc Brisson, Tajel Parekh, Russel E. Pike, Srikanth Venkatraman, Stephane L. Bogen, Sony Agrawal, Yi-Tsung Liu, Anil K. Saksena
Publikováno v:
Journal of Medicinal Chemistry. 49:2750-2757
Introduction of various modified prolines at P(2) and optimization of the P(1) side chain led to the discovery of SCH6 (24, Table 2), a potent ketoamide inhibitor of the HCV NS3 serine protease. In addition to excellent enzyme potency (K(i)*= 3.8 nM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3d177beeb1725aa51e250b5f8f869a
https://doi.org/10.1021/jm060077j
https://doi.org/10.1021/jm060077j
Autor:
Srikanth, Venkatraman, Stéphane L, Bogen, Ashok, Arasappan, Frank, Bennett, Kevin, Chen, Edwin, Jao, Yi-Tsung, Liu, Raymond, Lovey, Siska, Hendrata, Yuhua, Huang, Weidong, Pan, Tejal, Parekh, Patrick, Pinto, Veljko, Popov, Russel, Pike, Sumei, Ruan, Bama, Santhanam, Bancha, Vibulbhan, Wanli, Wu, Weiying, Yang, Jianshe, Kong, Xiang, Liang, Jesse, Wong, Rong, Liu, Nancy, Butkiewicz, Robert, Chase, Andrea, Hart, Sony, Agrawal, Paul, Ingravallo, John, Pichardo, Rong, Kong, Bahige, Baroudy, Bruce, Malcolm, Zhuyan, Guo, Andrew, Prongay, Vincent, Madison, Lisa, Broske, Xiaoming, Cui, Kuo-Chi, Cheng, Yunsheng, Hsieh, Jean-Marc, Brisson, Danial, Prelusky, Walter, Korfmacher, Ronald, White, Susan, Bogdanowich-Knipp, Anastasia, Pavlovsky, Prudence, Bradley, Anil K, Saksena, Ashit, Ganguly, John, Piwinski, Viyyoor, Girijavallabhan, F George, Njoroge
Publikováno v:
Journal of medicinal chemistry. 49(20)
Hepatitis C virus (HCV) infection is the major cause of chronic liver disease, leading to cirrhosis and hepatocellular carcinoma, which affects more than 170 million people worldwide. Currently the only therapeutic regimens are subcutaneous interfero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d829742096e46d140179bde31ce0d830
https://pubmed.ncbi.nlm.nih.gov/17004721
https://pubmed.ncbi.nlm.nih.gov/17004721