Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Bahareh Eftekharzadeh"'
Autor:
Bahareh Eftekharzadeh, Varuna C. Banduseela, Giulio Chiesa, Paula Martínez-Cristóbal, Jennifer N. Rauch, Samir R. Nath, Daniel M. C. Schwarz, Hao Shao, Marta Marin-Argany, Claudio Di Sanza, Elisa Giorgetti, Zhigang Yu, Roberta Pierattelli, Isabella C. Felli, Isabelle Brun-Heath, Jesús García, Ángel R. Nebreda, Jason E. Gestwicki, Andrew P. Lieberman, Xavier Salvatella
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Hsp chaperones stabilize the inactive conformation of androgen receptor (AR) and are released upon hormone-induced AR activation. Here, the authors locate the Hsp binding region on AR, and show that Hsp70 reduces AR aggregation and promotes AR degrad
Externí odkaz:
https://doaj.org/article/6c6c515e273b446cb66da2f55b7b3d95
Autor:
Albert Escobedo, Busra Topal, Micha B. A. Kunze, Juan Aranda, Giulio Chiesa, Daniele Mungianu, Ganeko Bernardo-Seisdedos, Bahareh Eftekharzadeh, Margarida Gairí, Roberta Pierattelli, Isabella C. Felli, Tammo Diercks, Oscar Millet, Jesús García, Modesto Orozco, Ramon Crehuet, Kresten Lindorff-Larsen, Xavier Salvatella
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Polyglutamine (polyQ) tracts are low-complexity regions and their expansion is linked to certain neurodegenerative diseases. Here the authors combine experimental and computational approaches to find that the length of the androgen receptor polyQ tra
Externí odkaz:
https://doaj.org/article/1f190bc76aba4d9fb248940a644fa9a9
Autor:
Ana Claudia Amaral, Beatriz G. Perez-Nievas, Michael Siao Tick Chong, Alicia Gonzalez-Martinez, Herminia Argente-Escrig, Sara Rubio-Guerra, Caitlin Commins, Serra Muftu, Bahareh Eftekharzadeh, Eloise Hudry, Zhanyun Fan, Prianca Ramanan, Shuko Takeda, Matthew P. Frosch, Susanne Wegmann, Teresa Gomez-Isla
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102058- (2021)
Summary: It has been suggested that aberrant activation of glycogen synthase kinase-3-beta (GSK-3β) can trigger abnormal tau hyperphosphorylation and aggregation, which ultimately leads to neuronal/synaptic damage and impaired cognition in Alzheimer
Externí odkaz:
https://doaj.org/article/0834daf1f0d14cb1bd40b2f5ea69e654
Autor:
Samantha B Nicholls, Sarah L DeVos, Caitlin Commins, Chloe Nobuhara, Rachel E Bennett, Diana L Corjuc, Eduardo Maury, Bahareh Eftekharzadeh, Ololade Akingbade, Zhanyun Fan, Allyson D Roe, Shuko Takeda, Susanne Wegmann, Bradley T Hyman
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177914 (2017)
The spread of neurofibrillary tangle (NFT) pathology through the human brain is a hallmark of Alzheimer's disease (AD), which is thought to be caused by the propagation of "seeding" competent soluble misfolded tau. "TauC3", a C-terminally truncated f
Externí odkaz:
https://doaj.org/article/6b7577e645ef4883bb7ef913fa08713d
Autor:
Bahareh Eftekharzadeh, Varuna C. Banduseela, Giulio Chiesa, Paula Martínez-Cristóbal, Jennifer N. Rauch, Samir R. Nath, Daniel M. C. Schwarz, Hao Shao, Marta Marin-Argany, Claudio Di Sanza, Elisa Giorgetti, Zhigang Yu, Roberta Pierattelli, Isabella C. Felli, Isabelle Brun-Heath, Jesús García, Ángel R. Nebreda, Jason E. Gestwicki, Andrew P. Lieberman, Xavier Salvatella
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/d1198cecc1114d42ba57e2c691ec211c
Publikováno v:
Molecular and Cellular Biochemistry. 477:1327-1327
Autor:
Tammo Diercks, Micha B. A. Kunze, Oscar Millet, Jesús García, Busra Topal, Albert Escobedo, Giulio Chiesa, Xavier Salvatella, Isabella C. Felli, Modesto Orozco, Kresten Lindorff-Larsen, Juan Aranda, Roberta Pierattelli, Ramon Crehuet, Bahareh Eftekharzadeh
Publikováno v:
Biophysical Journal. 118:369a-370a
Autor:
Isabella C. Felli, Jesús García, Roberta Pierattelli, Samir R. Nath, Paula Martínez-Cristóbal, Giulio Chiesa, Andrew P. Lieberman, Zhigang Yu, Xavier Salvatella, Daniel M. C. Schwarz, Claudio Di Sanza, Bahareh Eftekharzadeh, Jennifer N. Rauch, Elisa Giorgetti, Varuna C. Banduseela, Marta Marin-Argany, Isabelle Brun-Heath, Angel R. Nebreda, Jason E. Gestwicki, Hao Shao
Publikováno v:
Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
Nature Communications
Molecular chaperones such as Hsp40 and Hsp70 hold the androgen receptor (AR) in an inactive conformation. They are released in the presence of androgens, enabling transactivation and causing the receptor to become aggregation-prone. Here we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3006d7de3e115a9649d8bf1c63fb04
https://escholarship.org/uc/item/1s17d7p6
https://escholarship.org/uc/item/1s17d7p6
Autor:
Kresten Lindorff-Larsen, Juan Aranda, Jesús T. García, Ganeko Bernardo-Seisdedos, Giulio Chiesa, Ramon Crehuet, Oscar Millet, Margarida Gairí, Micha B. A. Kunze, Busra Topal, Xavier Salvatella, Daniele Mungianu, Albert Escobedo, Bahareh Eftekharzadeh, Roberta Pierattelli, Isabella C. Felli, Tammo Diercks, Modesto Orozco
Publikováno v:
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Escobedo, A, Topal, B, Kunze, M B A, Aranda, J, Chiesa, G, Mungianu, D, Bernardo-Seisdedos, G, Eftekharzadeh, B, Gairí, M, Pierattelli, R, Felli, I C, Diercks, T, Millet, O, García, J, Orozco, M, Crehuet, R, Lindorff-Larsen, K & Salvatella, X 2019, ' Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor ', Nature Communications, vol. 10, 2034 . https://doi.org/10.1038/s41467-019-09923-2
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Escobedo, A, Topal, B, Kunze, M B A, Aranda, J, Chiesa, G, Mungianu, D, Bernardo-Seisdedos, G, Eftekharzadeh, B, Gairí, M, Pierattelli, R, Felli, I C, Diercks, T, Millet, O, García, J, Orozco, M, Crehuet, R, Lindorff-Larsen, K & Salvatella, X 2019, ' Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor ', Nature Communications, vol. 10, 2034 . https://doi.org/10.1038/s41467-019-09923-2
Polyglutamine (polyQ) tracts are regions of low sequence complexity frequently found in transcription factors. Tract length often correlates with transcriptional activity and expansion beyond specific thresholds in certain human proteins is the cause
Autor:
Teresa Gomez-Isla, Shuko Takeda, Prianca Ramanan, Caitlin Commins, Alicia Gonzalez-Martinez, Beatriz G. Pérez-Nievas, Ana C. Amaral, Sara Rubio-Guerra, Susanne Wegmann, Bahareh Eftekharzadeh, Herminia Argente-Escrig, Zhanyun Fan, Matthew P. Frosch, Michael Siao Tick Chong, Serra Muftu, Eloise Hudry
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102058-(2021)
iScience
iScience
Summary It has been suggested that aberrant activation of glycogen synthase kinase-3-beta (GSK-3β) can trigger abnormal tau hyperphosphorylation and aggregation, which ultimately leads to neuronal/synaptic damage and impaired cognition in Alzheimer