Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Bahareh Amirloo"'
Autor:
Olga Patutina, Daria Chiglintseva, Bahareh Amirloo, David Clarke, Svetlana Gaponova, Valentin Vlassov, Elena Bichenkova, Marina Zenkova
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6562 (2022)
The selective degradation of disease-associated microRNA is promising for the development of new therapeutic approaches. In this study, we engineered a series of bulge-loop-forming oligonucleotides conjugated with catalytic peptide [(LeuArg)2Gly]2 (B
Externí odkaz:
https://doaj.org/article/ba817a51cbfa427fa049c4cfab602216
Autor:
Yaroslav Staroseletz, Svetlana Gaponova, Olga Patutina, Elena Bichenkova, Bahareh Amirloo, Thomas Heyman, Daria Chiglintseva, Marina Zenkova
Publikováno v:
Molecules, Vol 26, Iss 6, p 1732 (2021)
RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are curren
Externí odkaz:
https://doaj.org/article/b6e2f145e1c94415a4b34c09e00a009c
Autor:
Aimee Donald, Jane Potter, Heather J. Church, Bahareh Amirloo, James Cooper, Christine Egerton, Kelly E. Watts, Rebekah A. Hutton, Stewart Rust, Rebecca Bromley, Stavros M. Stivaros, Mathews Adera, Essra Ridha, Milena Veselinovic, Simon A. Jones, Robert Wynn, Alexander Broomfield
Publikováno v:
Molecular Genetics and Metabolism. 138:107083
Autor:
Valentin V. Vlassov, Elena V. Bichenkova, Marina A. Zenkova, Bahareh Amirloo, S. K. Miroshnichenko, O. A. Patutina
Publikováno v:
Russian Journal of Bioorganic Chemistry. 45:803-812
Nowadays, application of miRNases—artificial ribonucleases aimed at degradation of noncoding RNAs, in particular, miRNAs—represents one of the novel experimental approaches to inhibit tumorigenesis. miRNases integrate in their structure an addres
Autor:
Bahareh Amirloo, Yaroslav Staroseletz, Sameen Yousaf, David J Clarke, Tom Brown, Harmesh Aojula, Marina A Zenkova, Elena V Bichenkova
Publikováno v:
Nucleic Acids Research
Amirloo, B, Staroseletz, Y, Yousaf, S, Clarke, D J, Brown, T, Aojula, H, Zenkova, M A & Bichenkova, E V 2021, ' “Bind, cleave and leave”: multiple turnover catalysis of RNA cleavage by bulge–loop inducing supramolecular conjugates ', Nucleic acids research . https://doi.org/10.1093/nar/gkab1273
Amirloo, B, Staroseletz, Y, Yousaf, S, Clarke, D J, Brown, T, Aojula, H, Zenkova, M A & Bichenkova, E V 2021, ' “Bind, cleave and leave”: multiple turnover catalysis of RNA cleavage by bulge–loop inducing supramolecular conjugates ', Nucleic acids research . https://doi.org/10.1093/nar/gkab1273
Antisense sequence-specific knockdown of pathogenic RNA offers opportunities to find new solutions for therapeutic treatments. However, to gain a desired therapeutic effect, the multiple turnover catalysis is critical to inactivate many copies of eme
Autor:
Marina A. Zenkova, David Clarke, Tom Brown, Bahareh Amirloo, Kepa K. Burusco, Alexander A. Lomzov, Aled Williams, Elena V. Bichenkova, Yaroslav Staroseletz
Publikováno v:
Staroseletz, Y, Amirloo, B, Williams, A, Lomzov, A, Burusco, K, Clarke, D J, Brown, T, Zenkova, M A & Bichenkova, E 2020, ' Strict conformational demands of RNA cleavage in bulge-loops created by peptidyl-oligonucleotide conjugates ', Nucleic acids research, vol. 48, no. 19, pp. 10662-10679 . https://doi.org/10.1093/nar/gkaa780
University of Manchester-PURE
Staroseletz, Y, Amirloo, B, Williams, A, Lomzov, A, Burusco-Goni, K, Clarke, D, Brown, T, Zenkova, M A & Bichenkova, E 2020, ' Strict conformational demands of RNA cleavage in bulgeloops created by peptidyl-oligonucleotide conjugates ', Nucleic Acids Res, vol. 48, no. 19, pp. 10662-10679 . < https://doi.org/10.1093/nar/gkaa780 >
Nucleic Acids Research
University of Manchester-PURE
Staroseletz, Y, Amirloo, B, Williams, A, Lomzov, A, Burusco-Goni, K, Clarke, D, Brown, T, Zenkova, M A & Bichenkova, E 2020, ' Strict conformational demands of RNA cleavage in bulgeloops created by peptidyl-oligonucleotide conjugates ', Nucleic Acids Res, vol. 48, no. 19, pp. 10662-10679 . < https://doi.org/10.1093/nar/gkaa780 >
Nucleic Acids Research
Potent knockdown of pathogenic RNA in vivo is an urgent health need unmet by both small-molecule and biologic drugs. ‘Smart’ supramolecular assembly of catalysts offers precise recognition and potent destruction of targeted RNA, hitherto not foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3370e00e689f01039fccc16fa1d0b0f
https://www.research.manchester.ac.uk/portal/en/publications/strict-conformational-demands-of-rna-cleavage-in-bulgeloops-created-by-peptidyloligonucleotide-conjugates(faa0502c-dbe3-4266-83ca-0e4fa9f90b67).html
https://www.research.manchester.ac.uk/portal/en/publications/strict-conformational-demands-of-rna-cleavage-in-bulgeloops-created-by-peptidyloligonucleotide-conjugates(faa0502c-dbe3-4266-83ca-0e4fa9f90b67).html
Autor:
Svetlana Gaponova, O. A. Patutina, Daria Chiglintseva, Thomas Heyman, Yaroslav Staroseletz, Bahareh Amirloo, Elena V. Bichenkova, Marina A. Zenkova
Publikováno v:
Molecules
Staroseletz, Y, Gaponova, S, Patutina, O, Bichenkova, E, Amirloo, B, Heyman, T, Chiglintseva, D & Zenkova, M 2021, ' Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences ', Molecules, vol. 26, no. 6, 1732 . https://doi.org/10.3390/molecules26061732
Molecules, Vol 26, Iss 1732, p 1732 (2021)
Staroseletz, Y, Gaponova, S, Patutina, O, Bichenkova, E, Amirloo, B, Heyman, T, Chiglintseva, D & Zenkova, M 2021, ' Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences ', Molecules, vol. 26, no. 6, 1732 . https://doi.org/10.3390/molecules26061732
Molecules, Vol 26, Iss 1732, p 1732 (2021)
RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are curren