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Heteromultimeric sarbecovirus receptor binding domain immunogens primarily generate variant-specific neutralizing antibodies.

Autor: Trinity Zang, Kuffour, Edmund Osei, Baharani, Viren A., Canis, Marie, Schmidt, Fabian, Da Silva, Justin, Lercher, Alexander, Chaudhary, Pooja, Hoffmann, Hans-Heinrich, Gazumyan, Anna, Miranda, Ileana C., MacDonald, Margaret R., Rice, Charles M., Nussenzweig, Michel C., Hatziioannou, Theodora, Bieniasz, Paul D.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 12/19/2023, Vol. 120 Issue 51, p1-12, 23p

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Bispecific antibodies with broad neutralization potency against SARS-CoV-2 variants of concern.

Autor: Rubio AA; Stanford Biosciences, Stanford School of Medicine; Stanford, USA.; Department of Biology, Stanford University; Stanford, USA., Baharani VA; Laboratory of Retrovirology, The Rockefeller University; New York, USA.; Laboratory of Molecular Immunology, The Rockefeller University; New York, USA., Dadonaite B; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center; Seattle, USA., Parada M; Department of Biology, Stanford University; Stanford, USA., Abernathy ME; Department of Biology, Stanford University; Stanford, USA., Wang Z; Laboratory of Molecular Immunology, The Rockefeller University; New York, USA., Lee YE; Department of Biology, Stanford University; Stanford, USA., Eso MR; Department of Biology, Stanford University; Stanford, USA., Phung J; Department of Biology, Stanford University; Stanford, USA., Ramos I; Department of Biology, Stanford University; Stanford, USA., Chen T; Department of Biology, Stanford University; Stanford, USA., Nesr GE; Stanford Biosciences, Stanford School of Medicine; Stanford, USA., Bloom JD; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center; Seattle, USA.; Howard Hughes Medical Institute; Chevy Chase, USA., Bieniasz PD; Laboratory of Retrovirology, The Rockefeller University; New York, USA.; Howard Hughes Medical Institute; Chevy Chase, USA., Nussenzweig MC; Laboratory of Molecular Immunology, The Rockefeller University; New York, USA.; Howard Hughes Medical Institute; Chevy Chase, USA., Barnes CO; Department of Biology, Stanford University; Stanford, USA.; ChEM-H Institute, Stanford University; Stanford, CA.; Chan Zuckerberg Biohub; San Francisco, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 06. Date of Electronic Publication: 2024 May 06.