Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Baharan Fekry"'
Autor:
Rachel Van Drunen, Yulin Dai, Haichao Wei, Baharan Fekry, Sina Noori, Samay Shivshankar, Rafael Bravo, Zhongming Zhao, Seung-hee Yoo, Nicholas Justice, Jia Qian Wu, Qingchun Tong, Kristin Eckel-Mahan
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114380- (2024)
Summary: Circadian rhythms are internal biological rhythms driving temporal tissue-specific, metabolic programs. Loss of the circadian transcription factor BMAL1 in the paraventricular nucleus (PVN) of the hypothalamus reveals its importance in metab
Externí odkaz:
https://doaj.org/article/f22c96455dcb4bc4974719b6c4a5baca
HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver
Autor:
Jonathan R. Deans, Poonamjot Deol, Nina Titova, Sarah H. Radi, Linh M. Vuong, Jane R. Evans, Songqin Pan, Johannes Fahrmann, Jun Yang, Bruce D. Hammock, Oliver Fiehn, Baharan Fekry, Kristin Eckel-Mahan, Frances M. Sladek
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Hepatocyte Nuclear Factor 4α (HNF4α), a master regulator of hepatocyte differentiation, is regulated by two promoters (P1 and P2) which drive the expression of different isoforms. P1-HNF4α is the major isoform in the adult liver while P2-HNF4α is
Externí odkaz:
https://doaj.org/article/e1a980aa2c3548fca155dbc6f3c46efe
Autor:
Gang Li, Xin Li, Iqbal Mahmud, Jazmin Ysaguirre, Baharan Fekry, Shuyue Wang, Bo Wei, Kristin L. Eckel-Mahan, Philip L. Lorenzi, Richard Lehner, Kai Sun
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Hepatocellular carcinoma (HCC) is the most common lethal form of liver cancer. Apart from surgical removal and transplantation, other treatments have not yet been well established for patients with HCC. In this study, we found that carboxylesterase 1
Externí odkaz:
https://doaj.org/article/de92de44d5f74854adf94990735933e3
Autor:
Myrthala Moreno-Smith, Giorgio Milazzo, Ling Tao, Baharan Fekry, Bokai Zhu, Mahmoud A. Mohammad, Simone Di Giacomo, Roshan Borkar, Karthik Reddy Kami Reddy, Mario Capasso, Sanjeev A. Vasudevan, Pavel Sumazin, John Hicks, Nagireddy Putluri, Giovanni Perini, Kristin Eckel-Mahan, Thomas P. Burris, Eveline Barbieri
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
MYCN is frequently amplified in neuroblastomas. Here, the authors show that MYCN disrupts the molecular clock by downregulating clock activator RORα and that the reactivation of RORα restores BMAL1 activity, and inhibits lipid metabolism and neurob
Externí odkaz:
https://doaj.org/article/36f78ce6f76041c49c8161f0733a70f4
Autor:
Aleix Ribas-Latre, Rafael Bravo Santos, Baharan Fekry, Yomna M. Tamim, Samay Shivshankar, Alaa M. T. Mohamed, Corrine Baumgartner, Christopher Kwok, Claudia Gebhardt, Angielyn Rivera, Zhanguo Gao, Kai Sun, John T. Heiker, Brad E. Snyder, Mikhail G. Kolonin, Kristin L. Eckel-Mahan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
During the expansion of adipose tissue adipocyte progenitor cells proliferate and undergo adipogenesis. Here, the authors show that adipocyte progenitor cell proliferation in visceral adipose tissue has a diurnal pattern, which is dependent on both e
Externí odkaz:
https://doaj.org/article/d2bcdacfb8da49f1947d4b6f3b07213c
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Mammalian species contain an internal circadian (i.e., 24-h) clock that is synchronized to the day and night cycles. Large epidemiological studies, which are supported by carefully controlled studies in numerous species, support the idea that chronic
Externí odkaz:
https://doaj.org/article/765ea6fee9f64867beeeb6ec865ec95d
Autor:
Baharan Fekry, Kristen A. Jeffries, Amin Esmaeilniakooshkghazi, Zdzislaw M. Szulc, Kevin J. Knagge, David R. Kirchner, David A. Horita, Sergey A. Krupenko, Natalia I. Krupenko
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here authors show that C16-ceramide binds to the tumor suppressor p53, disrupts its interaction with MDM2 and facilitates p53 accumulation and act
Externí odkaz:
https://doaj.org/article/c8bb01b97ed94da88a335f1f599d147e
Autor:
Baharan Fekry, Aleix Ribas-Latre, Corrine Baumgartner, Jonathan R. Deans, Christopher Kwok, Pooja Patel, Loning Fu, Rebecca Berdeaux, Kai Sun, Mikhail G. Kolonin, Sidney H. Wang, Seung-Hee Yoo, Frances M. Sladek, Kristin Eckel-Mahan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Hepatocyte nuclear factor 4 alpha (HNF4α) is regulated by different promoters to generate two isoforms, one of which functions as a tumor suppressor. Here, the authors reveal that induction of the alternative isoform in hepatocellular carcinoma inhi
Externí odkaz:
https://doaj.org/article/056eef75c52b4174ad77b500303fd84c
Autor:
Aleix Ribas-Latre, Rafael Bravo Santos, Baharan Fekry, Yomna M. Tamim, Samay Shivshankar, Alaa M. T. Mohamed, Corrine Baumgartner, Christopher Kwok, Claudia Gebhardt, Angielyn Rivera, Zhanguo Gao, Kai Sun, John T. Heiker, Brad E. Snyder, Mikhail G. Kolonin, Kristin L. Eckel-Mahan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/35948522b3234d209efccb45c80c9f81
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146618 (2016)
We previously reported that ceramide synthase 6 (CerS6) is elevated in response to folate stress in cancer cells, leading to enhanced production of C16-ceramide and apoptosis. Antifolate methotrexate (MTX), a drug commonly used in chemotherapy of sev
Externí odkaz:
https://doaj.org/article/9e2d5263dda7445890c283dce96545f1