Two dose levels of once-weekly fosravuconazole versus daily itraconazole in combination with surgery in patients with eumycetoma in Sudan: a randomised, double-blind, phase 2, proof-of-concept superiority trial.

Autor: Fahal AH; Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan. Electronic address: ahfahal@hotmail.com., Ahmed ES; Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan., Bakhiet SM; Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan; Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan., Bakhiet OE; Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan., Fahal LA; Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan., Mohamed AA; Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan., Mohamedelamin ESW; Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan; Department of Surgery, Faculty of Medicine, Alneelain University, Khartoum, Sudan., Bahar MEN; Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan., Attalla HY; Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan., Siddig EE; Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan; Department of Medical Microbiology and Infectious Diseases, University Medical Center Rotterdam, Erasmus MC, Rotterdam, Netherlands., Mhmoud NA; Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan., Musa AM; Mycetoma Research Centre, University of Khartoum, Khartoum, Sudan; Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan., van de Sande WWJ; Department of Medical Microbiology and Infectious Diseases, University Medical Center Rotterdam, Erasmus MC, Rotterdam, Netherlands., Scherrer B; Bruno Scherrer Conseil, Saint Arnoult en Yvelines, France., Oyieko P; Drugs for Neglected Diseases initiative (DNDi), Nairobi, Kenya., Egondi TW; Drugs for Neglected Diseases initiative (DNDi), Nairobi, Kenya., Onyango KO; Drugs for Neglected Diseases initiative (DNDi), Nairobi, Kenya., Hata K; Global Health Research Section, Eisai, Tsukuba, Japan., Chu WY; Department of Pharmacy, Uppsala University, Uppsala, Sweden., Dorlo TPC; Department of Pharmacy, Uppsala University, Uppsala, Sweden., Brüggemann RJ; Department of Pharmacy and Radboudumc-CWZ Center of Expertise in Mycology, Radboud University Medical Center, Nijmegen, Netherlands., Nyaoke BA; Drugs for Neglected Diseases initiative (DNDi), Nairobi, Kenya., Strub-Wourgaft N; Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland., Zijlstra EE; Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland.

Publikováno v: The Lancet. Infectious diseases [Lancet Infect Dis] 2024 Nov; Vol. 24 (11), pp. 1254-1265. Date of Electronic Publication: 2024 Aug 01.