Zobrazeno 1 - 10 of 94 pro vyhledávání: '"Bahar, Tunctan"'
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Akademický článek
Pyroptosis and necroptosis inhibitor necrosulfonamide ameliorates lipopolysaccharide-induced inflammatory hyperalgesia in mice
Autor: Beyza Ozgen, Sefika Pinar Senol, Dilsah Ezgi Yilmaz, Meryem Temiz-Resitoglu, Omer Bahceli, Bahar Tunctan
Publikováno v: Pharmacia, Vol 70, Iss 4, Pp 1345-1354 (2023)
Objectives: This study aimed to investigate the effect of the gasdermin D (GSDMD) and mixed lineage kinase domain-like pseudokinase (MLKL) inhibitor, necrosulfonamide (NSA), on lipopolysaccharide (LPS)-induced hyperalgesia in mice. Methods: Reaction
Externí odkaz: https://doaj.org/article/d3682546f2bc4a95a1924a6cfab0b36d
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3
mTOR inhibition as a possible pharmacological target in the management of systemic inflammatory response and associated neuroinflammation by lipopolysaccharide challenge in rats
Autor: Deniz Kibar, Meryem Temiz-Resitoglu, Demet Sinem Guden, Şakir Necat Yılmaz, Kafait U. Malik, Sefika Pinar Senol, Seyhan Sahan-Firat, Bahar Tunctan
Publikováno v: Canadian Journal of Physiology and Pharmacology. 99:921-934
Neuroinflammation plays a critical role during sepsis triggered by microglial activation. Mammalian target of rapamycin (mTOR) has gained attraction in neuroinflammation, however, the mechanism remains unclear. Our goal was to assess the effects of m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b13f7469fbe44a26ebdf034f6edf4f9
https://doi.org/10.1139/cjpp-2020-0487
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4
Pyroptosis and Necroptosis Inhibitor Necrosulfonamide Prevents Lipopolysaccharide-Induced Inflammatory Hyperalgesia in Mice
Autor: Beyza Ozgen, Sefika Pinar Senol, Dilsah Ezgi Yilmaz, Meryem Temiz-Resitoglu, Omer Bahceli, Bahar Tunctan
Recent studies have demonstrated that two distinct forms of necrotic cell death, pyroptosis, and necroptosis, triggered by the lipid A part of lipopolysaccharide (LPS) are involved in the pathogenesis of several neurodegenerative diseases associated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a288769e52451f4c3e0ee29b3200f12
https://doi.org/10.21203/rs.3.rs-1727695/v1
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6
Suppression of TLR4/MyD88/TAK1/NF-κB/COX-2 Signaling Pathway in the Central Nervous System by Bexarotene, a Selective RXR Agonist, Prevents Hyperalgesia in the Lipopolysaccharide-Induced Pain Mouse Model
Autor: Meryem Temiz-Resitoglu, Seyhan Sahan-Firat, Sefika Pinar Senol, Demet Sinem Guden, Ayse Nihal Sari, Bahar Tunctan
Publikováno v: Neurochemical Research. 46:624-637
A selective RXR agonist, bexarotene, has been shown to have anti-inflammatory, anti-nociceptive, and neuroprotective effects in several models of numerous neurological diseases characterized by systemic inflammation. The mechanisms underlying these e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1fa0bb65e17f1828235b1c72b3804d
https://doi.org/10.1007/s11064-020-03197-7
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8
NLRX1 Ligand, Docosahexaenoic Acid, Ameliorates LPS-Induced Inflammatory Hyperalgesia by Decreasing TRAF6/IKK/IkB-a/NF-kB Signaling Pathway Activity
Autor: Dilsah Ezgi Yilmaz, Sefika Pinar Senol, Meryem Temiz-Resitoglu, Seyhan Sahan-Firat, Bahar Tunctan
Objective The nucleotide-binding oligomerization domain-like receptor X1 (NLRX1) has been associated with various anti-inflammatory mechanisms. We investigated whether the NLRX1 ligand docosahexaenoic acid (DHA) ameliorates lipopolysaccharide (LPS)-i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b603a9ed81187d766293db6fa66ad27d
https://doi.org/10.21203/rs.3.rs-1403191/v1
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Modulation of oxidative–nitrosative stress and inflammatory response by rapamycin in target and distant organs in rats exposed to hindlimb ischemia–reperfusion: the role of mammalian target of rapamycin
Autor: Seyhan Sahan-Firat, Senay Balci, Özden Vezir, Lulufer Tamer-Gumus, Bahar Tunctan, Meryem Temiz-Resitoglu, Kafait U. Malik, Zumrut Kocak, Demet Sinem Guden, Nehir Sucu
Publikováno v: Canadian Journal of Physiology and Pharmacology. 97:1193-1203
Mammalian target of rapamycin (mTOR) has been recognized with potential immunomodulatory properties playing an important role in various physiopathological processes including ischemia–reperfusion (I/R) injury. I/R injury stimulate reactive oxygen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac436769f8ee2eab3293a06a07ba755e
https://doi.org/10.1139/cjpp-2019-0394
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10
Activation of GPR75 Signaling Pathway Contributes to the Effect of a 20-HETE Mimetic, 5,14-HEDGE, to Prevent Hypotensive and Tachycardic Responses to Lipopolysaccharide in a Rat Model of Septic Shock
Autor: Bahar Tunctan, Sefika Pinar Senol, Meryem Temiz-Resitoglu, Dilsah Ezgi Yilmaz, Demet Sinem Guden, Omer Bahceli, Mehmet Furkan Horat, Seyhan Sahan-Firat, Ayse Nihal Sari, John R. Falck, Raghunath Reddy Anugu, Kafait U. Malik
Publikováno v: Journal of cardiovascular pharmacology. 80(2)
The orphan receptor, G protein-coupled receptor (GPR) 75, which has been shown to mediate various effects of 20-hydroxyeicosatetraenoic acid (20-HETE), is considered as a therapeutic target in the treatment of cardiovascular diseases in which changes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e7a8caeece3d61696c612a8e6217c7
https://pubmed.ncbi.nlm.nih.gov/35575984
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