Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Bahaa Salem"'
Autor:
Holger Sellner, Emilie Chapeau, Pascal Furet, Markus Voegtle, Bahaa Salem, Mickaël Le Douget, Vincent Bordas, Jean‐Marc Groell, Anne‐Laure Le Goff, Christine Rouzet, Thomas Wietlisbach, Thomas Zimmermann, Joseph McKenna, Cara E. Brocklehurst, Patrick Chène, Markus Wartmann, Clemens Scheufler, Joerg Kallen, Gareth Williams, Stephanie Harlfinger, Martin Traebert, Bérengère M. Dumotier, Tobias Schmelzle, Nicolas Soldermann
Publikováno v:
ChemMedChem.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87689f9fe496e8ff4e8b8008d72b261f
https://doi.org/10.1002/cmdc.202300051
https://doi.org/10.1002/cmdc.202300051
Autor:
Pascal Furet, Vincent Bordas, Mickaël Le Douget, Bahaa Salem, Yannick Mesrouze, Patricia Imbach‐Weese, Holger Sellner, Markus Voegtle, Nicolas Soldermann, Emilie Chapeau, Markus Wartmann, Clemens Scheufler, Cesar Fernandez, Joerg Kallen, Vito Guagnano, Patrick Chène, Tobias Schmelzle
Publikováno v:
ChemMedChem. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72eaa7a7b52b189acf9bc634916ec5d3
https://doi.org/10.1002/cmdc.202200514
https://doi.org/10.1002/cmdc.202200514
Autor:
Pascal Furet, Vincent Bordas, Mickaël Le Douget, Bahaa Salem, Yannick Mesrouze, Patricia Imbach‐Weese, Holger Sellner, Markus Voegtle, Nicolas Soldermann, Emilie Chapeau, Markus Wartmann, Clemens Scheufler, Cesar Fernandez, Joerg Kallen, Vito Guagnano, Patrick Chène, Tobias Schmelzle
Publikováno v:
ChemMedChem. 17(19)
Inhibition of the YAP-TEAD protein-protein interaction is an attractive therapeutic concept under intense investigation with the objective to treat cancers associated with a dysregulation of the Hippo pathway. However, owing to the very extended surf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e849912e1b00046650c0d4b1f52f7eb
https://pubmed.ncbi.nlm.nih.gov/35950546
https://pubmed.ncbi.nlm.nih.gov/35950546
Autor:
Pascal Furet, Bahaa Salem, Yannick Mesrouze, Tobias Schmelzle, Ian Lewis, Joerg Kallen, Patrick Chène
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2316-2319
The YAP-TEAD protein-protein interaction is a potential therapeutic target to treat cancers in which the Hippo signaling pathway is deregulated. However, the extremely large surface of interaction between the two proteins presents a formidable challe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3a1187429823abe9c5c6490df7f137
https://doi.org/10.1016/j.bmcl.2019.06.022
https://doi.org/10.1016/j.bmcl.2019.06.022
Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1
Autor:
Sandra W. Cowan-Jacob, A.A. Wylie, Bahaa Salem, J.M. Groell, Franco Lombardo, Peter Drueckes, Gabriele Rummel, Paul W. Manley, G. Berellini, Robert Martin Grotzfeld, Alice Loo, Markus Warmuth, Chrystelle Henry, Andreas Marzinzik, A.Q. Hassan, Xavier Pelle, V. Iyer, Stephanie Kay Dodd, Joseph Schoepfer, Simona Cotesta, Pascal Furet, Darryl Brynley Jones, Doriano Fabbro, Tobias Gabriel, Wolfgang Jahnke, S. Buonamici, Thomas Zoller
Publikováno v:
Journal of Medicinal Chemistry. 61:8120-8135
Chronic myelogenous leukemia (CML) arises from the constitutive activity of the BCR-ABL1 oncoprotein. Tyrosine kinase inhibitors (TKIs) that target the ATP-binding site have transformed CML into a chronic manageable disease. However, some patients de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43ca6c11f830ca5a00d41dc4c6b7d49
https://doi.org/10.1021/acs.jmedchem.8b01040
https://doi.org/10.1021/acs.jmedchem.8b01040
Autor:
Paul Erbel, Bernd Gerhartz, Frederic Cumin, Jürgen Maibaum, Nils Ostermann, Edwige Lorthiois, Claudio Dalvit, Thomas Zoller, Stefan Andreas Randl, Simon Rüdisser, Ulrich Hommel, Anna Vulpetti, Aengus Mac Sweeney, Bahaa Salem
Publikováno v:
Journal of Medicinal Chemistry. 60:1946-1958
Chronic dysregulation of alternative complement pathway activation has been associated with diverse clinical disorders including age-related macular degeneration and paroxysmal nocturnal hemoglobinurea. Factor D is a trypsin-like serine protease with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfc49de28df6dccc09e8711c747aed7
https://doi.org/10.1021/acs.jmedchem.6b01684
https://doi.org/10.1021/acs.jmedchem.6b01684
Autor:
François Gessier, Robert Mah, Philipp Holzer, Therese-Marie Stachyra, Andrea Vaupel, Vito Guagnano, Emmanuelle Wirth, Patrick Chène, Pascal Furet, Joseph Schoepfer, Aude Izaac, Bahaa Salem, Stefan Stutz, Joerg Kallen, Keiichi Masuya, Achim Schlapbach, Suzanne Chau
Publikováno v:
ChemMedChem. 14(14)
Hdm2 (human MDM2, human double minute 2 homologue) counteracts p53 function by direct binding to p53 and by ubiquitin-dependent p53 protein degradation. Activation of p53 by inhibitors of the p53-Hdm2 interaction is being pursued as a therapeutic str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f06228760b95695741263802f16121
https://pubmed.ncbi.nlm.nih.gov/31066983
https://pubmed.ncbi.nlm.nih.gov/31066983
Autor:
Aude Izaac, Stefan Stutz, Patrick Chène, Emmanuelle Wirth, Achim Schlapbach, Keiichi Masuya, François Gessier, Robert Mah, Bahaa Salem, Andrea Vaupel, Therese-Marie Stachyra, Philipp Holzer, Vito Guagnano, Joseph Schoepfer, Pascal Furet, Joerg Kallen, Suzanne Chau
Publikováno v:
ChemMedChem. 14:1304-1304
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efe94a39c43df4c5bdda9b5a4aab3872
https://doi.org/10.1002/cmdc.201900400
https://doi.org/10.1002/cmdc.201900400
Publikováno v:
Organic Letters. 10:1075-1078
Two new palladium catalyzed cascade reactions involving a 4-exo-dig cyclocarbopalladation are described. These processes are shown to convert bromoenediynes and bromodienynes into strained aromatic compounds in a single step.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da32fcdb62a56a4e2726a7dab7ad58b
https://doi.org/10.1021/ol702855h
https://doi.org/10.1021/ol702855h
Autor:
Ken Yamada, Hyi-Man Park, Dean F Rigel, Keith DiPetrillo, Erin J Whalen, Anthony Anisowicz, Michael Beil, James Berstler, Cara Emily Brocklehurst, Debra A Burdick, Shari L Caplan, Michael P Capparelli, Guanjing Chen, Wei Chen, Bethany Dale, Lin Deng, Fumin Fu, Norio Hamamatsu, Kouki Harasaki, Tracey Herr, Peter Hoffmann, Qi-Ying Hu, Waan-Jeng Huang, Neeraja Idamakanti, Hidetomo Imase, Yuki Iwaki, Monish Jain, Jey Jeyaseelan, Mitsunori Kato, Virendar K Kaushik, Darcy Kohls, Vidya Kunjathoor, Daniel LaSala, Jongchan Lee, Jing Liu, Yang Luo, Fupeng Ma, Ruowei Mo, Sarah Mowbray, Muneto Mogi, Flavio Ossola, Pramod Pandey, Sejal J Patel, Swetha Raghavan, Bahaa Salem, Yuka H Shanado, Gary M Trakshel, Gordon Turner, Hiromichi Wakai, Chunhua Wang, Stephen Weldon, Jennifer B Wielicki, Xiaoling Xie, Lingfei Xu, Yukiko I Yagi, Kayo Yasoshima, Jianning Yin, David Yowe, Ji-Hu Zhang, Gang Zheng, Lauren Monovich
Publikováno v:
Nature chemical biology. 12(11)
The With-No-Lysine (K) (WNK) kinases play a critical role in blood pressure regulation and body fluid and electrolyte homeostasis. Herein, we introduce the first orally bioavailable pan-WNK-kinase inhibitor, WNK463, that exploits unique structural fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78087a9853125909a6b388fbc86c95c9
https://pubmed.ncbi.nlm.nih.gov/27595330
https://pubmed.ncbi.nlm.nih.gov/27595330