A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels

Autor: Minor, Daniel, Renslo, Adam, Arkin, Michelle, Bagriantsev, SN, Ang, KH, Gallardo-Godoy, A, Clark, KA, Arkin, MR, Renslo, AR, Minor, DL

Publikováno v: Minor, Daniel; Renslo, Adam; Arkin, Michelle; Bagriantsev, SN; Ang, KH; Gallardo-Godoy, A; et al.(2013). A high-throughput functional screen identifies small molecule regulators of temperature-and mechano-sensitive K2P channels. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/5jc0k9qr

K2P (KCNK) potassium channels generate "leak" potassium currents that strongly influence cellular excitability and contribute to pain, somatosensation, anesthesia, and mood. Despite their physiological importance, K2Ps lack specific pharmacology. Add

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::a00fa9123faa6890241244e04e6df793
http://www.escholarship.org/uc/item/5jc0k9qr

Suppression of neurons in circumventricular organs enables months-long survival without water in thirteen-lined ground squirrels.

Autor: Junkins MS; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.; Department of Neuroscience and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, USA., Feng NY; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.; Department of Neuroscience and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, USA., Merriman DK; Department of Biology, University of Wisconsin-Oshkosh, Oshkosh, WI, USA., Bagriantsev SN; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA., Gracheva EO; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.; Department of Neuroscience and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT, USA.; Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Nov 29; Vol. 386 (6725), pp. 1048-1055. Date of Electronic Publication: 2024 Nov 28.

Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation.

Autor: Mohr SM; Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.; Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.; Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA., Dai Pra R; Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.; Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.; Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA., Platt MP; Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.; Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.; Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA., Feketa VV; Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.; Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.; Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA., Shanabrough M; Department of Comparative Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven, CT, 06510, USA., Varela L; Department of Comparative Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven, CT, 06510, USA.; Laboratory of Glia-Neuron Interactions in the Control of Hunger. Achucarro_Basque Center for Neuroscience, 48940, Leioa, Vizcaya, Spain.; IKERBASQUE, Basque Foundation for Science, 48009, Bilbao, Vizcaya, Spain., Kristant A; Department of Comparative Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven, CT, 06510, USA., Cao H; Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.; Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.; Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA., Merriman DK; Department of Biology, University of Wisconsin-Oshkosh, 800 Algoma Boulevard, Oshkosh, WI, 54901, USA., Horvath TL; Department of Comparative Medicine, Yale University School of Medicine, 310 Cedar Street, New Haven, CT, 06510, USA.; Laboratory of Glia-Neuron Interactions in the Control of Hunger. Achucarro_Basque Center for Neuroscience, 48940, Leioa, Vizcaya, Spain.; IKERBASQUE, Basque Foundation for Science, 48009, Bilbao, Vizcaya, Spain., Bagriantsev SN; Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA. slav.bagriantsev@yale.edu., Gracheva EO; Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA. elena.gracheva@yale.edu.; Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA. elena.gracheva@yale.edu.; Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA. elena.gracheva@yale.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Jul 10; Vol. 15 (1), pp. 5803. Date of Electronic Publication: 2024 Jul 10.

Neural control of fluid homeostasis is engaged below 10°C in hibernation.

Autor: Junkins MS; Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA; Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA; Department of Neuroscience and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA., Feng NY; Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA; Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA; Department of Neuroscience and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA; Neuroscience & Behavior Program, Wesleyan University, 52 Lawn Ave, Middletown, CT 06459, USA. Electronic address: nfeng@wesleyan.edu., Murphy LA; Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA., Curtis G; Department of Biology, Wesleyan University, 52 Lawn Ave, Middletown, CT 06459, USA., Merriman DK; Department of Biology, University of Wisconsin-Oshkosh, 800 Algoma Blvd, Oshkosh, WI 54901, USA., Bagriantsev SN; Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA. Electronic address: slav.bagriantsev@yale.edu., Gracheva EO; Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA; Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA; Department of Neuroscience and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA; Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA. Electronic address: elena.gracheva@yale.edu.

Publikováno v: Current biology : CB [Curr Biol] 2024 Feb 26; Vol. 34 (4), pp. 923-930.e5. Date of Electronic Publication: 2024 Feb 06.

Ground squirrels - experts in thermoregulatory adaptation.

Autor: Feketa VV; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, USA., Bagriantsev SN; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA. Electronic address: slav.bagriantsev@yale.edu., Gracheva EO; Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, CT 06510, USA; Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: elena.gracheva@yale.edu.

Publikováno v: Trends in neurosciences [Trends Neurosci] 2023 Jul; Vol. 46 (7), pp. 505-507. Date of Electronic Publication: 2023 May 13.