Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1

Autor: Peng, R, Wang, CK, Wang-Kan, X, Idorn, M, Kjaer, M, Zhou, FY, Fiil, BK, Timmermann, F, Orozco, SL, McCarthy, J, Leung, CS, Lu, X, Bagola, K, Rehwinkel, J, Oberst, A, Maelfait, J, Paludan, SR, Gyrd-Hansen, M

Publikováno v: Peng, R, Wang, C K, Wang-Kan, X, Idorn, M, Kjær, M, Zhou, F Y, Fiil, B K, Timmermann, F, Orozco, S L, McCarthy, J, Leung, C S, Lu, X, Bagola, K, Rehwinkel, J, Oberst, A, Maelfait, J, Paludan, S R & Gyrd-Hansen, M 2022, ' Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1 ', EMBO Reports, vol. 23, no. 12, e55839 . https://doi.org/10.15252/embr.202255839
EMBO REPORTS
Peng, R, Wang, C K, Wang-Kan, X, Idorn, M, Kjær, M, Zhou, F Y, Fiil, B K, Timmermann, F, Orozco, S L, McCarthy, J, Leung, C S, Lu, X, Bagola, K, Rehwinkel, J, Oberst, A, Maelfait, J, Paludan, S R & Gyrd-Hansen, M 2022, ' Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1 ', EMBO Reports, vol. 2022, no. 23, e55839 . https://doi.org/10.15252/embr.202255839

ZBP1 is an interferon-induced cytosolic nucleic acid sensor that facilitates antiviral responses via RIPK3. Although ZBP1-mediated programmed cell death is widely described, whether and how it promotes inflammatory signaling is unclear. Here, we repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40f7543eefb2e1eae82a204855bccc8
https://pure.au.dk/portal/da/publications/human-zbp1-induces-cell-deathindependent-inflammatory-signaling-via-ripk3-and-ripk1(c05320ff-0f70-4a24-aa88-b795c357a0c3).html

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

Autor: Elliott, P, Leske, D, Hrdinka, M, Bagola, K, Fiil, B, McLaughlin, S, Wagstaff, J, Volkmar, N, Christianson, J, Kessler, B, Freund, S, Komander, D, Gyrd-Hansen, M

Publikováno v: Molecular Cell

Summary The linear ubiquitin chain assembly complex (LUBAC) regulates immune signaling, and its function is regulated by the deubiquitinases OTULIN and CYLD, which associate with the catalytic subunit HOIP. However, the mechanism through which CYLD i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8662c00be1c4f28a2e088da7af8df185

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