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The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome

Autor: Davis Terence, Rokicki Michal J, Bagley Mark C, Kipling David

Publikováno v: Chemistry Central Journal, Vol 7, Iss 1, p 18 (2013)

Abstract Fibroblasts derived from the progeroid Werner syndrome (WS) show reduced replicative lifespan and a “stressed” morphology, both phenotypes being alleviated by using the p38 MAP kinase inhibitor SB203580. Because p38 is a major hub for th

Externí odkaz: https://doaj.org/article/a37748b05bac45568e2edce271f3bce1

Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors

Autor: Davis Terence, Dix Matthew C, Rokicki Michal J, Brook Amy JC, Widdowson Caroline S, Kipling David, Bagley Mark C

Publikováno v: Chemistry Central Journal, Vol 5, Iss 1, p 83 (2011)

Abstract Fibroblasts derived from the progeroid Werner syndrome show reduced replicative lifespan and a "stressed" morphology, both alleviated using the MAP kinase inhibitor SB203580. However, interpretation of these data is problematical because alt

Externí odkaz: https://doaj.org/article/018cb1d453e94afa94c94e6ab50eace1

New benefit-sharing principles for digital sequence information.

Autor: Halewood M; Alliance of Bioversity International and the International Center for Tropical Agriculture, Rome, Italy., Bagley MA; Emory University School of Law, Atlanta, GA, USA., Wyss M; DSM Nutritional Products Ltd, Kaiseraugst, Switzerland., Scholz AH; Leibniz Institute DSMZ, German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.

Publikováno v: Science (New York, N.Y.) [Science] 2023 Nov 03; Vol. 382 (6670), pp. 520-522. Date of Electronic Publication: 2023 Nov 02.