Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Baggavalli P Somesh"'
Autor:
Michelle Harreman, Joan W. Conaway, Stephanie E. Kong, James F. Reid, Baggavalli P. Somesh, Jesper Q. Svejstrup, Ronald C. Conaway, Stefan Sigurdsson, Charles A.S. Banks, Roy Anindya, Michael Taschner
Publikováno v:
Proceedings of the National Academy of Sciences. 106:20705-20710
The proteasome degrades proteins modified by polyubiquitylation, so correctly controlled ubiquitylation is crucial to avoid unscheduled proteolysis of essential proteins. The mechanism regulating proteolysis of RNAPII has been controversial since two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f1e464bd3438b4af09d59e76438b9d
https://doi.org/10.1073/pnas.0907052106
https://doi.org/10.1073/pnas.0907052106
Autor:
Jesper Q. Svejstrup, Paul Tempst, Hideaki Saeki, Baggavalli P. Somesh, Stefan Sigurdsson, Hediye Erdjument-Bromage
Publikováno v:
Cell. 129:57-68
SummaryTranscriptional arrest triggers ubiquitylation of RNA polymerase II (RNAPII). We mapped the yeast RNAPII ubiquitylation sites and found that they play an important role in elongation and the DNA-damage response. One site lies in a protein doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee4e65522240b85975edd705c36add2
https://doi.org/10.1016/j.cell.2007.01.046
https://doi.org/10.1016/j.cell.2007.01.046
Publikováno v:
Traffic. 7:1194-1212
Dictyostelium RacH localizes predominantly to membranes of the nuclear envelope, endoplasmic reticulum and Golgi apparatus. To investigate the role of this protein, we generated knockout and overexpressor strains. RacH-deficient cells displayed 50% r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8cef9689ae92b6d46b7b20278ee0e5e
https://doi.org/10.1111/j.1600-0854.2006.00455.x
https://doi.org/10.1111/j.1600-0854.2006.00455.x
Autor:
Jesper Q. Svejstrup, James Reid, Baggavalli P. Somesh, Wei-Feng Liu, T. Max M. Søgaard, Paul Tempst, Hediye Erdjument-Bromage
Publikováno v:
Cell. 121(6):913-923
SummaryIn order to study mechanisms and regulation of RNA polymerase II (RNAPII) ubiquitylation and degradation, highly purified factors were used to reconstitute RNAPII ubiquitylation in vitro. We show that arrested RNAPII elongation complexes are t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8a04796f04a016214dea85b92ecdbf
Autor:
Nicola Adam, Heidrun Dislich, Ann-Kathrin Meyer, Francisco Rivero, Baggavalli P. Somesh, Daria Illenberger
Publikováno v:
The EMBO Journal. 21:4539-4549
Rho GDP‐dissociation inhibitors (RhoGDIs) modulate the cycling of Rho GTPases between active GTP‐bound and inactive GDP‐bound states. We identified two RhoGDI homologues in Dictyostelium . GDI1 shares 51–58% similarity to RhoGDIs from diverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3dca683d2de6a7d67e5ed2765d81d0
https://doi.org/10.1093/emboj/cdf449
https://doi.org/10.1093/emboj/cdf449
Autor:
Baggavalli P. Somesh, Francisco Rivero
Publikováno v:
Journal of Muscle Research and Cell Motility. 23:737-749
Rho GTPases are ubiquitously expressed across the eukaryotes where they act as molecular switches, cycling between an active GTP-bound state and an inactive GDP-bound state. Activation enables Rho GTPases to interact with a multitude of effectors tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee6d98800a7da9bc35981cb0cdb98ae4
https://doi.org/10.1023/a:1024423611223
https://doi.org/10.1023/a:1024423611223
Autor:
Shivakumar Pratibha, Anilkumar Dandu, Bobbili Madhusudhan Reddy, Sivakumaran Yogeshwari, Mudigere N Lakshmi, Mahesh Kumar Verma, Manoj Kumar Sadasivuni, Mammen O Anup, Puttrevana M Pallavi, Madanahalli R Jagannath, Marikunte V Venkataranganna, Jaideep Singh, Chandrashekaran Harish, Baggavalli P Somesh, Yoganand Moolemath, Venkategowda Sunil, Suni K. Chacko, Baisani S Naveenkumar, Aralakuppe S Gopala, Talanki Lokesh Pooja
Publikováno v:
Diabetology & Metabolic Syndrome
Background In addition to their role in growth, cellular differentiation and homeostasis Retinoid X Receptors (RXR) regulate multiple physiological and metabolic pathways in various organs that have beneficial glucose and lipid (cholesterol) lowering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b6a0801aa383aed51853cf7d3f62a2
https://doi.org/10.1186/1758-5996-6-83
https://doi.org/10.1186/1758-5996-6-83
Autor:
Anup M. Oommen, Kandoor Sandhya, Baggavalli P Somesh, Niketa Pawar, Mahesh Kumar Verma, Puttrevana M Pallavi, Mudigere N Lakshmi, Jayaram Poornima, Korrapati Neelima, Aggunda Nagaraju Yateesh, Madanahalli R Jagannath, Sivakumaran Yogeshwari
Publikováno v:
SpringerPlus
Background Chronic metabolic overload leads to insulin resistance in a variety of tissues. It has been shown that exposure to saturated fatty acid palmitate can cause insulin resistance in skeletal muscle cells. Fatty acid induced synthesis of cerami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13fc7288bc4a3eb5822e5a21c2433e6
https://doi.org/10.1186/2193-1801-3-255
https://doi.org/10.1186/2193-1801-3-255
Autor:
Baggavalli P Somesh, Mahesh Kumar Verma, Puttrevana M Pallavi, Korrapati Neelima, Madanahalli R Jagannath, Anup M. Oommen, Madhusudhan Reddy, Jayaram Poornima, Aggunda Nagaraju Yateesh, Rachapalli Smitha
Publikováno v:
SpringerPlus
Apart from elevated glucose, triglyceride and cholesterol, elevated levels of serum free-fatty acid (FFA) are observed in diabetic patients. Increased FFA load can cause multiple dysregulation which are collectively known as lipotoxicity. Impacts of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad43a0283f1f182f0548593df4c78ee
https://doi.org/10.1186/2193-1801-3-251
https://doi.org/10.1186/2193-1801-3-251
Autor:
Sanghamitra Biswas, Mahesh Kumar Verma, Puttrevana M Pallavi, Anup Mammen-Oommen, Baggavalli P Somesh, Pavagada C Shilpa, Korrapati Neelima, Manoj Kumar Sadasivuni, Madanahalli R Jagannath, G. Ashok Kumar Reddy, Aggunda Nagaraju Yateesh, Usha Narayanan, Rachapalli Smitha, Siddaraju Nethra
Publikováno v:
BMC Cell Biology
Background In the progression towards diabetes, glucolipotoxicity is one of the main causes of pancreatic beta cell pathology. The aim of this study was to examine the in vitro effects of chronic glucolipotoxic conditions on cellular responses in pan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be222637553867a7ff9c9cab13c466e6
https://pubmed.ncbi.nlm.nih.gov/23815372
https://pubmed.ncbi.nlm.nih.gov/23815372