Correction for Bagashev et al., 'CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum'

Autor: Asen, Bagashev, Elena, Sotillo, Chih-Hang Anthony, Tang, Kathryn L, Black, Jessica, Perazzelli, Steven H, Seeholzer, Yair, Argon, David M, Barrett, Stephan A, Grupp, Chih-Chi Andrew, Hu, Andrei, Thomas-Tikhonenko

Publikováno v: Molecular and Cellular Biology

We previously described a mechanism of acquired resistance of B-cell acute lymphoblastic leukemia to CD19-directed chimeric antigen receptor T-cell (CART) immunotherapy. It was based on in-frame insertions in or skipping of CD19 exon 2.
We previ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f38bea316891d2621a66602d6ecb94
https://pubmed.ncbi.nlm.nih.gov/30104252

Co-targeting of the thymic stromal lymphopoietin receptor to decrease immunotherapeutic resistance in CRLF2-rearranged Ph-like and Down syndrome acute lymphoblastic leukemia.

Autor: Balestra T; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Niswander LM; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Pediatrics, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA., Bagashev A; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Loftus JP; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Ross SL; Division of Hematology/Oncology/Bone Marrow Transplant and Center for Cancer and Blood Disorders, Children's Hospital of Colorado, Aurora, CO, USA., Chen RK; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., McClellan SM; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Junco JJ; Texas Children's Hospital Cancer Center and Division of Pediatric Hematology/Oncology, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Bárcenas López DA; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Rabin KR; Texas Children's Hospital Cancer Center and Division of Pediatric Hematology/Oncology, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Fry TJ; Division of Hematology/Oncology/Bone Marrow Transplant and Center for Cancer and Blood Disorders, Children's Hospital of Colorado, Aurora, CO, USA.; University of Colorado Anschutz Medical Campus and Gates Institute, Aurora, CO, USA., Tasian SK; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA. tasians@chop.edu.; Department of Pediatrics, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA. tasians@chop.edu.; Abramson Cancer Center, University of Pennsylvania, School of Medicine, Philadelphia, PA, USA. tasians@chop.edu.; Prinses Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. tasians@chop.edu.

Publikováno v: Leukemia [Leukemia] 2024 Dec 16. Date of Electronic Publication: 2024 Dec 16.

1514 In vivo CAR-M: redirecting endogenous myeloid cells with mRNA for cancer immunotherapy

Autor: Claudia Lee, Michael Klichinsky, Nicholas Minutolo, Yumi Ohtani, Kayleigh Ross, Rashid Gabbasov, Stefano Pierini, Thomas Condamine, Michael Ball, Rehman Qureshi, Alison Worth, Bindu Varghese, Simone Mori, Asen Bagashev, Shuo Huang, Amanda Bona, Sherly Merdiana, Kate Slovik, Karan Nagar, Robert Saporito, Lauren Shaw, Kevin Tosh, Christine Lukacs, Lin Guey

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)

Externí odkaz: https://doaj.org/article/75c0cb542c3e49e7bb18e3dab52b85f6

HIV-1 gp120 Impairs Spatial Memory Through Cyclic AMP Response Element-Binding Protein

Autor: Jenny Shrestha, Maryline Santerre, Charles N. S. Allen, Sterling P. Arjona, Carmen Merali, Ruma Mukerjee, Kumaraswamy Naidu Chitrala, Jin Park, Asen Bagashev, Viet Bui, Eliseo A. Eugenin, Salim Merali, Marcus Kaul, Jeannie Chin, Bassel E. Sawaya

Publikováno v: Frontiers in Aging Neuroscience, Vol 14 (2022)

HIV-associated neurocognitive disorders (HAND) remain an unsolved problem that persists despite using antiretroviral therapy. We have obtained data showing that HIV-gp120 protein contributes to neurodegeneration through metabolic reprogramming. This

Externí odkaz: https://doaj.org/article/34ed7172ee7742b284b32f138f58b797

HIV-1 Tat protein promotes neuronal dysregulation by inhibiting E2F transcription factor 3 (E2F3)

Autor: Santerre, Maryline, Bagashev, Asen, Gorecki, Laura, Lysek, Kyle Z., Wang, Ying, Shrestha, Jenny, Del Carpio-Cano, Fabiola, Mukerjee, Ruma, Sawaya, Bassel E.

Publikováno v: In Journal of Biological Chemistry 8 March 2019 294(10):3618-3633