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2'- O -Alkyl- N ³ -Methyluridine Functionalized Passenger Strand Improves RNAi Activity by Modulating the Thermal Stability.

Autor: Sahoo A; Department of Chemistry, Indian Institute of Technology Kharagpur, West Bengal 721302, India., Gupta S; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India., Das G; Department of Chemistry, Indian Institute of Technology Kharagpur, West Bengal 721302, India., Ghosh A; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India., Bagale SS; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India., Sinha S; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India., Gore KR; Department of Chemistry, Indian Institute of Technology Kharagpur, West Bengal 721302, India.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Jul 16; Vol. 15 (8), pp. 1250-1259. Date of Electronic Publication: 2024 Jul 16 (Print Publication: 2024).

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Synthesis of N ² - trans -isosafrole-dG-adduct Bearing DNAs and the Bypass Studies with Human TLS Polymerases κ and η.

Autor: Bagale SS; Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Deshmukh PU; Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Lad SB; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Sudarsan A; Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Sudhakar S; Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Mandal S; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Kondabagil K; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Pradeepkumar PI; Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2024 Jun 07; Vol. 89 (11), pp. 7680-7691. Date of Electronic Publication: 2024 May 13.

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4'- C -Acetamidomethyl-2'- O -methoxyethyl Nucleic Acid Modifications Improve Thermal Stability, Nuclease Resistance, Potency, and hAgo2 Binding of Small Interfering RNAs.

Autor: Gangopadhyay S; Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India., Das G; Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India., Gupta S; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Kolkata, Jadavpur 700032, India., Ghosh A; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Kolkata, Jadavpur 700032, India., Bagale SS; Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India., Roy PK; School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India., Mandal M; School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India., Harikrishna S; Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, United States., Sinha S; School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Kolkata, Jadavpur 700032, India., Gore KR; Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2024 Mar 15; Vol. 89 (6), pp. 3747-3768. Date of Electronic Publication: 2024 Feb 23.

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Human Translesion Synthesis Polymerases polκ and polη Perform Error-Free Replication across N ² -dG Methyleugenol and Estragole DNA Adducts.

Autor: Deshmukh PU; Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Lad SB; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Sudarsan A; Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Sudhakar S; Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Aggarwal T; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Mandal S; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Bagale SS; Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Kondabagil K; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India., Pradeepkumar PI; Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.

Publikováno v: Biochemistry [Biochemistry] 2023 Aug 15; Vol. 62 (16), pp. 2391-2406. Date of Electronic Publication: 2023 Jul 24.

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