Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Baerbel Rohrer"'
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)
Abstract Background Traumatic brain injury (TBI) is associated with the development of visual system disorders. Visual deficits can present with delay and worsen over time, and may be associated with an ongoing neuroinflammatory response that is know
Externí odkaz:
https://doaj.org/article/29c6dc985f564b6b8b5674ef76f3c698
Autor:
Liyun Zhang, Conan Chen, Jie Fu, Brendan Lilley, Cynthia Berlinicke, Baranda Hansen, Ding Ding, Guohua Wang, Tao Wang, Daniel Shou, Ying Ye, Timothy Mulligan, Kevin Emmerich, Meera T Saxena, Kelsi R Hall, Abigail V Sharrock, Carlene Brandon, Hyejin Park, Tae-In Kam, Valina L Dawson, Ted M Dawson, Joong Sup Shim, Justin Hanes, Hongkai Ji, Jun O Liu, Jiang Qian, David F Ackerley, Baerbel Rohrer, Donald J Zack, Jeff S Mumm
Publikováno v:
eLife, Vol 10 (2021)
Retinitis pigmentosa (RP) and associated inherited retinal diseases (IRDs) are caused by rod photoreceptor degeneration, necessitating therapeutics promoting rod photoreceptor survival. To address this, we tested compounds for neuroprotective effects
Externí odkaz:
https://doaj.org/article/ae361e62a3fd4acc8161a7ed3eae9011
Autor:
Davis M. Borucki, Amer Toutonji, Christine Couch, Khalil Mallah, Baerbel Rohrer, Stephen Tomlinson
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The focus of this review is the role of complement-mediated phagocytosis in retinal and neurological diseases affecting the visual system. Complement activation products opsonize synaptic material on neurons for phagocytic removal, which is a normal
Externí odkaz:
https://doaj.org/article/6b66d9cb881e43a290eb6f3880e221a6
Publikováno v:
AIMS Molecular Science, Vol 4, Iss 4, Pp 446-462 (2017)
Multiple sclerosis (MS), the most common chronic autoimmune inflammatory disease of the central nervous system (CNS), is characterized by demyelination and neurodegeneration. In particular, neurodegeneration is a major factor in disease progression w
Externí odkaz:
https://doaj.org/article/9f5a88d63b9c405fb819a0f29c519d3d
Autor:
Cecile Nasarre, Yuri K. Peterson, Christopher C. Lindsey, Nathan Perron, Rick G. Schnellmann, Mausumi Bandyopadhyay, Baerbel Rohrer, Craig Beeson, Richard Comer, Gyda C. Beeson
Publikováno v:
J Ocul Pharmacol Ther
Purpose: Metabolic stress and associated mitochondrial dysfunction are implicated in retinal degeneration irrespective of the underlying cause. We identified seven unique chemicals from a Chembridge DiverSET screen and tested their protection against
Autor:
Ding Ding, Hyejin Park, Jeff S. Mumm, Conan Chen, Tae In Kam, Jiang Qian, Brendan Lilley, Valina L. Dawson, Baranda Hansen, Liyun Zhang, Carlene Brandon, Joong Sup Shim, Baerbel Rohrer, Ying Ye, Kevin Emmerich, Kelsi R. Hall, Jie Fu, Ted M. Dawson, Abigail V. Sharrock, Donald J. Zack, Guohua Wang, Meera T. Saxena, Daniel Shou, Jun O. Liu, David F. Ackerley, Justin Hanes, Tao Wang, Timothy Mulligan, Hongkai Ji, Cynthia Berlinicke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c69cbae701d04e068fd7fc0de67f867
https://doi.org/10.7554/elife.57245.sa2
https://doi.org/10.7554/elife.57245.sa2
Publikováno v:
Molecular Vision
Purpose: Recent reports linking HDAC6 to mitochondrial turnover and neurodegeneration led us to hypothesize that an inhibitor such as Vorinostat (suberoylanilide hydroxamic acid, SAHA) may reduce mitochondrial damage found in retinitis pigmentosa (RP
Autor:
Jiang Qian, Joong Sup Shim, Donald J. Zack, Conan Chen, Ding Ding, Daniel Daniel, Brendan Lilley, Jeff S. Mumm, Baerbel Rohrer, Abigail V. Sharrock, Jie Fu, Meera T. Saxena, David F. Ackerley, Jun O. Liu, Liyun Zhang, Carlene Brandon, Ying Ye, Justin Hanes, Cynthia Berlinicke, Guohua Wang, Baranda Hansen, Kelsi R. Hall, Hongkai Ji, Tao Wang
Retinitis pigmentosa (RP) and associated inherited retinal diseases (IRDs) are caused by rod photoreceptor degeneration, necessitating therapeutics promoting rod photoreceptor survival. To address this, we tested compounds for neuroprotective effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07e8a40ed40c8d757bc84ea9c27f4f3
https://doi.org/10.1101/2020.03.26.010009
https://doi.org/10.1101/2020.03.26.010009
Autor:
Jennifer R. DeRosa, Ellie Lumen, Kelsey Moody, Brandon S. Moyer, Justin Applegate, Jay Tinklepaugh, Meegan B. Sleeper, Danique Wortel, Emily Leary, Scott Campbell, Cheyanne Fisher, Baerbel Rohrer, Robert P. Doyle, Nicholas LeClair, Kris Grohn, Aaron J. Wolfe, Anthony H Bianchi, Adam R. Blanden, Elisabeth Obert
Publikováno v:
Rejuvenation research. 21(6)
Macular degeneration is hallmarked by retinal accumulation of toxic retinoid species (e.g., A2E) for which there is no endogenous mechanism to eliminate it. This ultimately results in progressive dysfunction and loss of vision either in advanced age
Autor:
Baerbel Rohrer, Ashish Sharma
Publikováno v:
The Journal of biological chemistry. 292(32)
The rd mouse, an accepted animal model for photoreceptor degeneration in retinitis pigmentosa, has a recessive mutation for the gene encoding the beta-subunit of the cGMP phosphodiesterase. This mutation results in high levels of cGMP, which leaves a