Výsledky vyhledávání - "Baek Soo, Han"

Akademický článek

Development of a novel sandwich immunoassay based on targeting recombinant Francisella outer membrane protein A for the diagnosis of tularemia

Autor: Jieun Jang, Do Hyung Kwon, Ju-Hong Jang, Dong-Gwang Lee, Seo-Hyuk Chang, Min-Young Jeon, Young-Su Jeong, Dong-Hyun Song, Jeong-Ki Min, Jong-Gil Park, Moo-Seung Lee, Baek-Soo Han, Wonjun Yang, Nam-Kyung Lee, Jangwook Lee

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

IntroductionTularemia, caused by the bacterium Francisella tularensis, poses health risks to humans and can spread through a variety of routes. It has also been classified as a Tier 1 Select agent by the CDC, highlighting its potential as a bioterror

Externí odkaz: https://doaj.org/article/29a8d14e70a24b25bc8ae03a2ece0266

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Akademický článek

The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Abstract Arachidonic and adrenic acids in the membrane play key roles in ferroptosis. Here, we reveal that lipoprotein-associated phospholipase A2 (Lp-PLA2) controls intracellular phospholipid metabolism and contributes to ferroptosis resistance. A m

Externí odkaz: https://doaj.org/article/f90ee655100f4a7dbd4a8f6ac8458b81

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Akademický článek

FSP1 confers ferroptosis resistance in KEAP1 mutant non-small cell lung carcinoma in NRF2-dependent and -independent manner

Autor: Jong Woo Kim, Min-Ju Kim, Tae-Hee Han, Ji-Yoon Lee, Sangok Kim, Hyerin Kim, Kyoung-Jin Oh, Won Kon Kim, Baek-Soo Han, Kwang-Hee Bae, Hyun Seung Ban, Soo Han Bae, Sang Chul Lee, Haeseung Lee, Eun-Woo Lee

Publikováno v: Cell Death and Disease, Vol 14, Iss 8, Pp 1-11 (2023)

Abstract Ferroptosis, a type of cell death induced by lipid peroxidation, has emerged as a novel anti-cancer strategy. Cancer cells frequently acquire resistance to ferroptosis. However, the underlying mechanisms are poorly understood. To address thi

Externí odkaz: https://doaj.org/article/08d83d3808054f3497b887ace45047b5

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Akademický článek

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Mitochondrial uncoupling protein 1 (UCP1) is activated in BAT during cold stress and dissipates mitochondrial proto

Externí odkaz: https://doaj.org/article/8abfab449c994b11bb6233d6bda9aba7

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Akademický článek

Cellular heterogeneity and plasticity during NAFLD progression

Autor: Hyun-Ju Park, Juyong Choi, Hyunmi Kim, Da-Yeon Yang, Tae Hyeon An, Eun-Woo Lee, Baek-Soo Han, Sang Chul Lee, Won Kon Kim, Kwang-Hee Bae, Kyoung-Jin Oh

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

Nonalcoholic fatty liver disease (NAFLD) is a progressive liver disease that can progress to nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis, and hepatocellular carcinoma (HCC). NAFLD ranges from simple steatosis (or nonalcoholic fatty li

Externí odkaz: https://doaj.org/article/1558977ee33d496d887d5e81baca706d

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Akademický článek

TGF-β and SHH Regulate Pluripotent Stem Cell Differentiation into Brain Microvascular Endothelial Cells in Generating an In Vitro Blood–Brain Barrier Model

Autor: Na Geum Lee, Mi-Hee Lim, Jongjin Park, In Cheul Jeung, Byungtae Hwang, Jangwook Lee, Jong-Gil Park, Mi-Young Son, Baek Soo Han, Sung-Jin Yoon, Seon-Jin Lee, Young-Jun Park, Jae Ho Kim, Nam-Kyung Lee, Sang Chul Lee, Jeong-Ki Min

Publikováno v: Bioengineering, Vol 10, Iss 10, p 1132 (2023)

Blood–brain barrier (BBB) models are important tools for studying CNS drug delivery, brain development, and brain disease. In vitro BBB models have been obtained from animals and immortalized cell lines; however, brain microvascular endothelial cel

Externí odkaz: https://doaj.org/article/52114e4b0b3a47f588a31fdc740cd693

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Akademický článek

A Sensitive Immunodetection Assay Using Antibodies Specific to Staphylococcal Enterotoxin B Produced by Baculovirus Expression

Autor: Ju-Hong Jang, Sungsik Kim, Seul-Gi Kim, Jaemin Lee, Dong-Gwang Lee, Jieun Jang, Young-Su Jeong, Dong-Hyun Song, Jeong-Ki Min, Jong-Gil Park, Moo-Seung Lee, Baek-Soo Han, Jee-Soo Son, Jangwook Lee, Nam-Kyung Lee

Publikováno v: Biosensors, Vol 12, Iss 10, p 787 (2022)

Staphylococcal enterotoxin B (SEB) is a potent bacterial toxin that causes inflammatory stimulation and toxic shock, thus it is necessary to detect SEB in food and environmental samples. Here, we developed a sensitive immunodetection system using mon

Externí odkaz: https://doaj.org/article/b07487003fab48128a024c35cf269921

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Akademický článek

3,6′- and 1,6′-Dithiopomalidomide Mitigate Ischemic Stroke in Rats and Blunt Inflammation

Autor: Yan-Rou Tsai, Dong Seok Kim, Shih-Chang Hsueh, Kai-Yun Chen, John Chung-Che Wu, Jia-Yi Wang, Yi-Syue Tsou, Inho Hwang, Yukyung Kim, Dayeon Gil, Eui Jung Jo, Baek-Soo Han, David Tweedie, Daniela Lecca, Michael T. Scerba, Warren R. Selman, Barry J. Hoffer, Nigel H. Greig, Yung-Hsiao Chiang

Publikováno v: Pharmaceutics, Vol 14, Iss 5, p 950 (2022)

(1) Background: An important concomitant of stroke is neuroinflammation. Pomalidomide, a clinically available immunomodulatory imide drug (IMiD) used in cancer therapy, lowers TNF-α generation and thus has potent anti-inflammatory actions. Well-tole

Externí odkaz: https://doaj.org/article/abe37d4afed640b4839048006b4ded35

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