Zobrazeno 1 - 10
of 1 829
pro vyhledávání: '"Baek Kim"'
Autor:
Chandra Bhushan Prasad, Adrian Oo, Yujie Liu, Zhaojun Qiu, Yaogang Zhong, Na Li, Deepika Singh, Xiwen Xin, Young-Jae Cho, Zaibo Li, Xiaoli Zhang, Chunhong Yan, Qingfei Zheng, Qi-En Wang, Deliang Guo, Baek Kim, Junran Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Checkpoint kinase 1 (CHK1) is critical for cell survival under replication stress (RS). CHK1 inhibitors (CHK1i’s) in combination with chemotherapy have shown promising results in preclinical studies but have displayed minimal efficacy with
Externí odkaz:
https://doaj.org/article/4e9f2011ac204a8f800749ef6ae41bf2
Autor:
Demis Menolfi, Brian J. Lee, Hanwen Zhang, Wenxia Jiang, Nicole E. Bowen, Yunyue Wang, Junfei Zhao, Antony Holmes, Steven Gershik, Raul Rabadan, Baek Kim, Shan Zha
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The ATR kinase, which coordinates cellular responses to DNA replication stress, is also essential for the proliferation of normal unstressed cells. Although its role in the replication stress response is well defined, the mechanisms by which
Externí odkaz:
https://doaj.org/article/d09bbaea5ecb4671897b8a2789d31420
Autor:
Moritz Schüssler, Kerstin Schott, Nina Verena Fuchs, Adrian Oo, Morssal Zahadi, Paula Rauch, Baek Kim, Renate König
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Sterile α motif and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphate triphosphohydrolase (dNTPase) and a potent restriction factor for immunodeficiency virus 1 (HIV-1), active in myeloid and resting CD4+ T cells. The anti-vira
Externí odkaz:
https://doaj.org/article/1c167ea212ec4a49b4f9019e5796d44f
Autor:
Priya Kapoor-Vazirani, Sandip K. Rath, Xu Liu, Zhen Shu, Nicole E. Bowen, Yitong Chen, Ramona Haji-Seyed-Javadi, Waaqo Daddacha, Elizabeth V. Minten, Diana Danelia, Daniela Farchi, Duc M. Duong, Nicholas T. Seyfried, Xingming Deng, Eric A. Ortlund, Baek Kim, David S. Yu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
SAMHD1 has a dNTPase-independent resection function in genome maintenance. Here the authors show that SAMHD1 is deacetylated at conserved K354 by SIRT1 to facilitate direct binding with ssDNA to promote DNA end resection and homologous recombination.
Externí odkaz:
https://doaj.org/article/28cc02127faa4de9bf5e662150744115
Autor:
Matthew R. Singer, Tung Dinh, Lev Levintov, Arun S. Annamalai, Juan S. Rey, Lorenzo Briganti, Nicola J. Cook, Valerie E. Pye, Ian A. Taylor, Kyungjin Kim, Alan N. Engelman, Baek Kim, Juan R. Perilla, Mamuka Kvaratskhelia, Peter Cherepanov
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are an emerging class of small molecules that disrupt viral maturation by inducing the aberrant multimerization of IN. Here, we present cocrystal structures of HIV-1 IN with two potent ALL
Externí odkaz:
https://doaj.org/article/18637d366ddf46828152a6725c46c973
Autor:
Tianai Sun, Chien-Kuang Cornelia Ding, Yuning Zhang, Yang Zhang, Chao-Chieh Lin, Jianli Wu, Yasaman Setayeshpour, Si’Ana Coggins, Caitlin Shepard, Everardo Macias, Baek Kim, Pei Zhou, Raluca Gordân, Jen-Tsan Chi
Publikováno v:
Cell Death and Disease, Vol 13, Iss 3, Pp 1-24 (2022)
Abstract All organisms are constantly exposed to various stresses, necessitating adaptive strategies for survival. In bacteria, the main stress-coping mechanism is the stringent response triggered by the accumulation of “alarmone” (p)ppGpp to arr
Externí odkaz:
https://doaj.org/article/7a49a4d8b7594d4a8a1846204b4d39c6
Autor:
Charlotte Martinat, Arthur Cormier, Joëlle Tobaly-Tapiero, Noé Palmic, Nicoletta Casartelli, Bijan Mahboubi, Si’Ana A. Coggins, Julian Buchrieser, Mirjana Persaud, Felipe Diaz-Griffero, Lucile Espert, Guillaume Bossis, Pascale Lesage, Olivier Schwartz, Baek Kim, Florence Margottin-Goguet, Ali Saïb, Alessia Zamborlini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
SAMHD1 is a cellular dNTPase proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting dNTP substrate supply; its anti-viral but not dNTPase function is downregulated by phosphorylation of T592. Here, Martinat et al. des
Externí odkaz:
https://doaj.org/article/70d02ba8c29446d69d93dada293f5c11
Autor:
Z. Ping Lin, Nour N. Al Zouabi, Mark L. Xu, Nicole E. Bowen, Terence L. Wu, Ethan S. Lavi, Pamela H. Huang, Yong-Lian Zhu, Baek Kim, Elena S. Ratner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Abstract Poly ADP-ribose polymerase (PARP) inhibitors are promising targeted therapy for epithelial ovarian cancer (EOC) with BRCA mutations or defective homologous recombination (HR) repair. However, reversion of BRCA mutation and restoration of HR
Externí odkaz:
https://doaj.org/article/7c21bcf75bea4e2ebab41ede567eddbb
Autor:
Corey H. Yu, Akash Bhattacharya, Mirjana Persaud, Alexander B. Taylor, Zhonghua Wang, Angel Bulnes-Ramos, Joella Xu, Anastasia Selyutina, Alicia Martinez-Lopez, Kristin Cano, Borries Demeler, Baek Kim, Stephen C. Hardies, Felipe Diaz-Griffero, Dmitri N. Ivanov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
SAMHD1 catalyses the dephosphorylation of deoxynucleotide triphosphates (dNTPs) and has antiretroviral activity. Here, the authors present the crystal structures of SAMHD1-oligonucleotide complexes, which reveal that the allosteric binding sites of S
Externí odkaz:
https://doaj.org/article/235030ae21f844b790931e36a84dca12
Autor:
Minakshi Gandhi, Matthias Groß, Jessica M. Holler, Si’Ana A. Coggins, Nitin Patil, Joerg H. Leupold, Mathias Munschauer, Monica Schenone, Christina R. Hartigan, Heike Allgayer, Baek Kim, Sven Diederichs
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Despite some well-characterized functions in cancer, the impact of most long non-coding RNAs remains unknown. Here, the authors discover the lncRNA lincNMR which is upregulated in cancer and drives cell proliferation by interacting with YBX1 and cont
Externí odkaz:
https://doaj.org/article/186c4d276d704b2c8e6ccb57bb201c3b