Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Baeckseung Lee"'
Autor:
Malika Hale, Baeckseung Lee, Yuchi Honaker, Wai-Hang Leung, Alexandra E. Grier, Holly M. Jacobs, Karen Sommer, Jaya Sahni, Shaun W. Jackson, Andrew M. Scharenberg, Alexander Astrakhan, David J. Rawlings
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 192-203 (2017)
Gene editing by homology-directed recombination (HDR) can be used to couple delivery of a therapeutic gene cassette with targeted genomic modifications to generate engineered human T cells with clinically useful profiles. Here, we explore the functio
Externí odkaz:
https://doaj.org/article/5c8a965f6c324b0c809e18b4b234bc06
Since mid-December of 2019, coronavirus disease 2019 (COVID-19) has been spreading from Wuhan, China. As of February 21, total 75,773 confirmed cases worldwide have spread to more than two dozen countries. Transmission of COVID-19 can occur early in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4a31bcbbf241afc01b4046cdf38211
https://doi.org/10.20944/preprints202002.0424.v1
https://doi.org/10.20944/preprints202002.0424.v1
Autor:
Jaegyun, Lim, Seunghyun, Jeon, Hyun Young, Shin, Moon Jung, Kim, Yu Min, Seong, Wang Jun, Lee, Kang Won, Choe, Yu Min, Kang, Baeckseung, Lee, Sang Joon, Park
Publikováno v:
Pharmacological Research
Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the
Autor:
Moon Jung Kim, Seung Hyun Jeon, Kang Won Choe, Yu Min Kang, Wang Jun Lee, Jaegyun Lim, Yu Min Seong, Baeckseung Lee, Sang Joon Park, Hyun-Young Shin
Publikováno v:
Journal of Korean Medical Science
Journal of Korean medical science, 35(6):e79
Journal of Korean medical science, 35(6):e79
Since mid-December of 2019, coronavirus disease 2019 (COVID-19) infection has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the
Autor:
Jaegyun Lim, Seunghyun Jeon, Hyun-Young Shin, Moon Jung Kim, Yu Min Seong, Wang Jun Lee, Kang-Won Choe, Yu Min Kang, Baeckseung Lee, Sang-Joon Park
Publikováno v:
Journal of Korean Medical Science
Autor:
Wai-Hang Leung, Alexandra E. Grier, David J. Rawlings, Andrew M. Scharenberg, Honaker Yuchi Chiang, Alexander Astrakhan, Jaya Sahni, Baeckseung Lee, Holly M. Jacobs, Malika Hale, Karen Sommer, Shaun W. Jackson
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 192-203 (2017)
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 192-203 (2017)
Gene editing by homology-directed recombination (HDR) can be used to couple delivery of a therapeutic gene cassette with targeted genomic modifications to generate engineered human T cells with clinically useful profiles. Here, we explore the functio
Autor:
Baeckseung Lee, Wai-Hang Leung, Jasdeep Mann, Kyle Havens, Joel Gay, Richard A. Morgan, Alexander Astrakhan
Publikováno v:
Cancer Research. 78:1536-1536
Chimeric antigen receptor (CAR) T cells have shown great promise in treating certain late stage hematological malignancies. While very encouraging, current CAR T cell therapies have not shown the same level of success in targeting solid tumors and al
Publikováno v:
Cancer Research. 77:3756-3756
Genetically engineered T cells represent a promising new approach to the treatment of cancer. Positive results in recent clinical trials exploiting T cells engineered to express chimeric antigen receptors (CARs) have highlighted the potential for the
Autor:
Karen Sommer, Jordan Jarjour, Jaya Sahni, Malika Hale, Baeckseung Lee, David J. Rawlings, Alexandra E. Grier, Guillermo S. Romano Ibarra, Nicholas Hasle, Honaker Yuchi Chiang, Andrew M. Scharenberg, Iram F. Khan, Alexander Astrakhan
Publikováno v:
Molecular Therapy. 24:S158
In current clinical trials, delivery of an anti-cancer chimeric antigen receptor (CAR) to patient T cells is accomplished using randomly integrating retroviruses. Designer nucleases and AAV donor templates allow an alternative delivery method that in
Publikováno v:
Molecular Therapy. 24:S130
Genetically engineered cancer targeting CAR-T cells have generated promising results in a series of B cell derived cancers. Development of these therapies for solid tumor applications has been much more difficult and will likely require extensive T c