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Akademický článek

Tet controls axon guidance in early brain development through glutamatergic signaling

Autor: Hiep Tran, Le Le, Badri Nath Singh, Joseph Kramer, Ruth Steward

Publikováno v: iScience, Vol 27, Iss 5, Pp 109634- (2024)

Summary: Mutations in ten-eleven translocation (TET) proteins are associated with human neurodevelopmental disorders. We find a function of Tet in regulating Drosophila early brain development. The Tet DNA-binding domain (TetAXXC) is required for axo

Externí odkaz: https://doaj.org/article/f834e7caaeef4c87932f35027f8db8a0

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Akademický článek

Tet-dependent 5-hydroxymethyl-Cytosine modification of mRNA regulates axon guidance genes in Drosophila.

Autor: Badri Nath Singh, Hiep Tran, Joseph Kramer, Elmira Kirichenko, Neha Changela, Fei Wang, Yaping Feng, Dibyendu Kumar, Min Tu, Jie Lan, Martin Bizet, François Fuks, Ruth Steward

Publikováno v: PLoS ONE, Vol 19, Iss 2, p e0293894 (2024)

Modifications of mRNA, especially methylation of adenosine, have recently drawn much attention. The much rarer modification, 5-hydroxymethylation of cytosine (5hmC), is not well understood and is the subject of this study. Vertebrate Tet proteins are

Externí odkaz: https://doaj.org/article/3ce50553810e4b2e8cb5a9fbd4184a4f

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Akademický článek

Inhibitory effect of natural flavone luteolin on Streptococcus mutans biofilm formation

Autor: Lucille Rudin, Noelle Roth, Julien Kneubühler, Badri Nath Dubey, Michael M. Bornstein, Viktoriya Shyp

Publikováno v: Microbiology Spectrum, Vol 11, Iss 5 (2023)

ABSTRACT Streptococcus mutans is one of the key pathogens responsible for dental caries, which is known to be one of the most prevalent biofilm-associated diseases worldwide. S. mutans virulence strongly depends on its biofilm formation and enamel de

Externí odkaz: https://doaj.org/article/aa8ae137b8044049b45bddd37a2122f7

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Akademický článek

Mutant structure of metabolic switch protein in complex with monomeric c-di-GMP reveals a potential mechanism of protein-mediated ligand dimerization

Autor: Badri Nath Dubey, Viktoriya Shyp, Geoffrey Fucile, Holger Sondermann, Urs Jenal, Tilman Schirmer

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

Abstract Bacterial second messengers c-di-GMP and (p)ppGpp have broad functional repertoires ranging from growth and cell cycle control to the regulation of biofilm formation and virulence. The recent identification of SmbA, an effector protein from

Externí odkaz: https://doaj.org/article/a71121d7c6894d3787826e29a4304299

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Akademický článek

Seeing Is Believing: Sharing Real-Time Visual Traffic Information via Vehicular Clouds

Autor: Daehan Kwak, Ruilin Liu, Daeyoung Kim, Badri Nath, Liviu Iftode

Publikováno v: IEEE Access, Vol 4, Pp 3617-3631 (2016)

From today's conventional cars to tomorrow's self-driving cars, advances in technology will enable vehicles to be equipped with more and more-sophisticated sensing devices, such as cameras. As vehicles gain the ability to act as mobile sensors that c

Externí odkaz: https://doaj.org/article/0b8c59b1469047269367ef6266459684

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Akademický článek

Over-expression of Topoisomerase II Enhances Salt Stress Tolerance in Tobacco

Autor: Riffat John, Uma Ganeshan, Badri Nath Singh, Tanushri Kaul, Malireddy K Reddy, Sudhir Kumar Sopory, Manchikatla Venkat Rajam

Publikováno v: Frontiers in Plant Science, Vol 7 (2016)

Topoisomerases are unique enzymes having an ability to remove or add DNA supercoils and untangle the snarled DNA. They can cut, shuffle and religate DNA strands and remove the torsional stress during DNA replication, transcription or recombination ev

Externí odkaz: https://doaj.org/article/7571f8cc68a04c8f9404b6f331c30fc0

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