Improving genetic prediction by leveraging genetic correlations among human diseases and traits

Autor: Maier, R. M., Zhu, Z., Lee, S. H., Trzaskowski, M., Ruderfer, D. M., Stahl, E. A., Ripke, S., Wray, N. R., Yang, J., Visscher, P. M., Robinson, M. R., Forstner, A. J., Mcquillin, A., Trubetskoy, V., Wang, W., Wang, Y., Coleman, J. R. I., Gaspar, H. A., Leeuw, C. A., Whitehead Pavlides, J. M., Olde Loohuis, L. M., Pers, T. H., Lee, P. H., Charney, A. W., Dobbyn, A. L., Huckins, L., Boocock, J., Giambartolomei, C., Roussos, P., Mullins, N., Awasthi, S., Agerbo, E., Als, T. D., Pedersen, C. B., Grove, J., Kupka, R., Regeer, E. J., Anjorin, A., Casas, M., Mahon, P. B., Allardyce, J., Escott-Price, V., Forty, L., Fraser, C., Kogevinas, M., Frank, J., Streit, F., Strohmaier, J., Treutlein, J., Witt, S. H., Kennedy, J. L., Strauss, J. S., Garnham, J., O Donovan, C., Slaney, C., Steinberg, S., Thorgeirsson, T. E., Hautzinger, M., Steffens, M., Perlis, R. H., Sánchez-Mora, C., Hipolito, M., Lawson, W. B., Nwulia, E. A., Levy, S. E., Foroud, T. M., Jamain, S., Young, A. H., Mckay, J. D., Albani, D., Zandi, P., Potash, J. B., Zhang, P., Raymond Depaulo, J., Bergen, S. E., Juréus, A., Karlsson, R., Kandaswamy, R., Mcguffin, P., Rivera, M., Lissowska, J., Cruceanu, C., Lucae, S., Cervantes, P., Budde, M., Gade, K., Heilbronner, U., Pedersen, M. G., Morris, D. W., Weickert, C. S., Weickert, T. W., Macintyre, D. J., Lawrence, J., Elvsåshagen, T., Smeland, O. B., Djurovic, S., Xi, S., Green, E. K., Czerski, P. M., Hauser, J., Xu, W., Vedder, H., Oruc, L., Spijker, A. T., Gordon, S. D., Medland, S. E., Curtis, D., Mühleisen, T. W., Badner, J. A., Scheftner, W. A., Sigurdsson, E., Schork, N. J., Schatzberg, A. F., Bækvad-Hansen, M., Bybjerg-Grauholm, J., Hansen, C. S., Knowles, J. A., Szelinger, S., Montgomery, G. W., Boks, M., Adolfsson, A. N., Hoffmann, P., Bauer, M., Pfennig, A., Leber, M., Kittel-Schneider, S., Reif, A., Del-Favero, J., Fischer, S. B., Herms, S., Reinbold, C. S., Degenhardt, F., Koller, A. C., Maaser, A., Ori, A. P. S., Dale, A. M., Fan, C. C., Greenwood, T. A., Nievergelt, C. M., Shehktman, T., Shilling, P. D., Byerley, W., Bunney, W., Alliey-Rodriguez, N., Clarke, T. K., Liu, C., Coryell, W., Akil, H., Burmeister, M., Flickinger, M., Li, J. Z., Mcinnis, M. G., Meng, F., Thompson, R. C., Watson, S. J., Zollner, S., Guan, W., Green, M. J., Craig, D., Sobell, J. L., Milani, L., Gordon-Smith, Katherine, Knott, Sarah, Perry, Amy, Parra, J. G., Mayoral, F., Rivas, F., Rice, J. P., Barchas, J. D., Børglum, A. D., Mortensen, P. B., Mors, O., Grigoroiu-Serbanescu, M., Bellivier, F., Etain, B., Leboyer, M., Ramos-Quiroga, J. A., Agartz, I., Amin, F., Azevedo, M. H., Bass, N., Black, D. W., Blackwood, D. H. R., Bruggeman, R., Buccola, N. G., Choudhury, K., Cloninger, C. R., Corvin, A., Craddock, N., Daly, M. J., Datta, S., Donohoe, G. J., Duan, J., Dudbridge, F., Fanous, A., Freedman, R., Freimer, N. B., Friedl, M., Gill, M., Gurling, H., Haan, L., Hamshere, M. L., Hartmann, A. M., Holmans, P. A., Kahn, R. S., Keller, M. C., Kenny, E., Kirov, G. K., Krabbendam, L., Krasucki, R., Lencz, T., Levinson, D. F., Lieberman, J. A., Lin, D. -Y, Linszen, D. H., Magnusson, P. K. E., Maier, W., Malhotra, A. K., Mattheisen, M., Mattingsdal, M., Mccarroll, S. A., Medeiros, H., Melle, I., Milanova, V., Myin-Germeys, I., Neale, B. M., Ophoff, R. A., Owen, M. J., Pimm, J., Purcell, S. M., Puri, V., Digby Quested, Rossin, L., Sanders, A. R., Shi, J., Sklar, P., St Clair, D., Stroup, T. S., Os, J., Wiersma, D., Zammit, S.

Publikováno v: Nature Communications
Nature Communications, 9(1):02769-6. Nature Publishing Group
Maier, R M, Zhu, Z, Lee, S H, Trzaskowski, M, Ruderfer, D M, Stahl, E A, Ripke, S, Wray, N R, Yang, J, Visscher, P M, Robinson, M R, Forstner, A J, Mcquillin, A, Trubetskoy, V, Wang, W, Wang, Y, Coleman, J R I, Gaspar, H A, De Leeuw, C A, Whitehead Pavlides, J M, Olde Loohuis, L M, Pers, T H, Lee, P H, Charney, A W, Dobbyn, A L, Huckins, L, Boocock, J, Giambartolomei, C, Roussos, P, Mullins, N, Awasthi, S, Agerbo, E, Als, T D, Pedersen, C B, Grove, J, Kupka, R, Regeer, E J, Anjorin, A, Casas, M, Mahon, P B, Allardyce, J, Escott-Price, V, Forty, L, Fraser, C, Kogevinas, M, Frank, J, Streit, F, Strohmaier, J & Treutlein, J 2018, ' Improving genetic prediction by leveraging genetic correlations among human diseases and traits ', Nature Communications, vol. 9, no. 1, 02769-6 . https://doi.org/10.1038/s41467-017-02769-6
Nature Communications, 9(1). Nature Publishing Group
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature communications, 9(1):02769-6. Nature Publishing Group
Maier, R M, Zhu, Z, Lee, S H, Trzaskowski, M, Ruderfer, D M, Stahl, E A, Ripke, S, Wray, N R, Yang, J, Visscher, P M, Robinson, M R, Forstner, A J, Mcquillin, A, Trubetskoy, V, Wang, W, Wang, Y, Coleman, J R I, Gaspar, H L A, de Leeuw, C A, Whitehead Pavlides, J M, Olde Loohuis, L M, Pers, T H, Lee, P H, Charney, A W, Dobbyn, A L, Huckins, L, Boocock, J, Giambartolomei, C, Roussos, P, Mullins, N, Awasthi, S, Agerbo, E, Als, T D, Pedersen, C B C, Grove, J, Kupka, R, Regeer, E J, Anjorin, A, Casas, M, Mahon, P B, Allardyce, J, Escott-Price, V, Forty, L, Fraser, C, Kogevinas, M, Frank, J, Streit, F, Strohmaier, J, Treutlein, J, Witt, S H, Kennedy, J L, Strauss, J S, Garnham, J, O'donovan, C, Slaney, C, Steinberg, S, Thorgeirsson, T E, Hautzinger, M, Steffens, M, Perlis, R H, Sánchez-Mora, C, Hipolito, M, Lawson, W B, Nwulia, E A, Levy, S E, Foroud, T M, Jamain, S, Young, A H, Mckay, J D, Albani, D, Zandi, P, Potash, J B, Zhang, P, Raymond Depaulo, J, Bergen, S E, Juréus, A, Karlsson, R, Kandaswamy, R, Mcguffin, P, Rivera, M, Lissowska, J, Cruceanu, C, Lucae, S, Cervantes, P, Budde, M, Gade, K, Heilbronner, U, Pedersen, M G, Morris, D W, Weickert, C S, Weickert, T W, Macintyre, D J, Lawrence, J, Elvsåshagen, T, Smeland, O B, Djurovic, S, Xi, S, Green, E K, Czerski, P M, Hauser, J, Xu, W, Vedder, H, Oruc, L, Spijker, A T, Gordon, S D, Medland, S E, Curtis, D, Mühleisen, T W, Badner, J, Scheftner, W A, Sigurdsson, E, Schork, N J, Schatzberg, A F, Bækvad-Hansen, M, Bybjerg-Grauholm, J, Hansen, C S H, Knowles, J A, Szelinger, S, Montgomery, G W, Boks, M, Adolfsson, A N, Hoffmann, P, Bauer, M, Pfennig, A, Leber, M, Kittel-Schneider, S, Reif, A, del-Favero, J, Fischer, S B, Herms, S, Reinbold, C L S, Degenhardt, F, Koller, A C, Maaser, A, Ori, A, Dale, A M, Fan, C C, Greenwood, T A, Nievergelt, C M, Shehktman, T, Shilling, P D, Byerley, W, Bunney, W, Alliey-Rodriguez, N, Clarke, T-K, Liu, C, Coryell, W, Akil, H, Burmeister, M, Flickinger, M, Li, J Z, Mcinnis, M G, Meng, F, Thompson, R C, Watson, S J, Zollner, S, Guan, W, Green, M J, Craig, D, Sobell, J L, Milani, L, Gordon-Smith, K, Knott, S V, Perry, A, Parra, J G, Mayoral, F, Rivas, F, Rice, J P, Barchas, J D, Børglum, A D, Mortensen, P B, Mors, O, Grigoroiu-Serbanescu, M, Bellivier, F, Etain, B, Leboyer, M, Ramos-Quiroga, J A, Agartz, I, Amin, F, Azevedo, M H, Bass, N, Black, D W, Blackwood, D H R, Bruggeman, R, Buccola, N G, Choudhury, K, Cloninger, C R, Corvin, A, Craddock, N, Daly, M J, Datta, S, Donohoe, G J, Duan, J, Dudbridge, F, Fanous, A, Freedman, R, Freimer, N B, Friedl, M, Gill, M, Gurling, H, de Haan, L, Hamshere, M L, Hartmann, A M, Holmans, P A, Kahn, R S, Keller, M C, Kenny, E, Kirov, G K, Krabbendam, L, Krasucki, R, Lencz, T, Levinson, D F, Lieberman, J A, Lin, D-Y, Linszen, D H, Magnusson, P K E, Maier, W, Malhotra, A K, Mattheisen, M, Mattingsdal, M, Mccarroll, S A, Medeiros, H, Melle, I, Milanova, V, Myin-Germeys, I, Neale, B M, Ophoff, R A, Owen, M J, Pimm, J, Purcell, S M, Puri, V, Quested, D J, Rossin, L, Sanders, A R, Shi, J, Sklar, P, St Clair, D, Stroup, T S, van Os, J, Wiersma, D & Zammit, S 2018, ' Improving genetic prediction by leveraging genetic correlations among human diseases and traits ', Nature Communications, vol. 9, no. 1, 02769-6 . https://doi.org/10.1038/s41467-017-02769-6
Nature communications, vol. 9, no. 1, pp. 989
Maier, R M, Zhu, Z, Lee, S H, Trzaskowski, M, Ruderfer, D M, Stahl, E A, Ripke, S, Wray, N R, Yang, J & Visscher, P M & Robinson, M R 2018, ' Improving genetic prediction by leveraging genetic correlations among human diseases and traits ', Nature Communications, vol. 9, no. 1, 989 . https://doi.org/10.1038/s41467-017-02769-6
Maier, R M, Zhu, Z, Lee, S H, Trzaskowski, M, Ruderfer, D M, Stahl, E A, Ripke, S, Wray, N R, Yang, J, Visscher, P M, Robinson, M R, Forstner, A J, Mcquillin, A, Trubetskoy, V, Wang, W, Wang, Y, Coleman, J R I, Gaspar, H A, De Leeuw, C A, Whitehead Pavlides, J M, Olde Loohuis, L M, Pers, T H, Lee, P H, Charney, A W, Dobbyn, A L, Huckins, L, Boocock, J, Giambartolomei, C, Roussos, P, Mullins, N, Awasthi, S, Agerbo, E, Als, T D, Pedersen, C B, Grove, J, Kupka, R, Regeer, E J, Anjorin, A, Casas, M, Mahon, P B, Allardyce, J, Escott-Price, V, Forty, L, Fraser, C, Kogevinas, M, Frank, J, Streit, F, Strohmaier, J, Treutlein, J, Witt, S H, Kennedy, J L, Strauss, J S, Garnham, J, O'donovan, C, Slaney, C, Steinberg, S, Thorgeirsson, T E, Hautzinger, M, Steffens, M, Perlis, R H, Sánchez-Mora, C, Hipolito, M, Lawson, W B, Nwulia, E A, Levy, S E, Foroud, T M, Jamain, S, Young, A H, Mckay, J D, Albani, D, Zandi, P, Potash, J B, Zhang, P, Raymond Depaulo, J, Bergen, S E, Juréus, A, Karlsson, R, Kandaswamy, R, Mcguffin, P, Rivera, M, Lissowska, J, Cruceanu, C, Lucae, S, Cervantes, P, Budde, M, Gade, K, Heilbronner, U, Pedersen, M G, Morris, D W, Weickert, C S, Weickert, T W, Macintyre, D J, Lawrence, J, Elvsåshagen, T, Smeland, O B, Djurovic, S, Xi, S, Green, E K, Czerski, P M, Hauser, J, Xu, W, Vedder, H, Oruc, L, Spijker, A T, Gordon, S D, Medland, S E, Curtis, D, Mühleisen, T W, Badner, J, Scheftner, W A, Sigurdsson, E, Schork, N J, Schatzberg, A F, Bækvad-Hansen, M, Bybjerg-Grauholm, J, Hansen, C S, Knowles, J A, Szelinger, S, Montgomery, G W, Boks, M, Adolfsson, A N, Hoffmann, P, Bauer, M, Pfennig, A, Leber, M, Kittel-Schneider, S, Reif, A, Del-Favero, J, Fischer, S B, Herms, S, Reinbold, C S, Degenhardt, F, Koller, A C, Maaser, A, Ori, A, Dale, A M, Fan, C C, Greenwood, T A, Nievergelt, C M, Shehktman, T, Shilling, P D, Byerley, W, Bunney, W, Alliey-Rodriguez, N, Clarke, T K, Liu, C, Coryell, W, Akil, H, Burmeister, M, Flickinger, M, Li, J Z, Mcinnis, M G, Meng, F, Thompson, R C, Watson, S J, Zollner, S, Guan, W, Green, M J, Craig, D, Sobell, J L, Milani, L, Gordon-Smith, K, Knott, S V, Perry, A, Parra, J G, Mayoral, F, Rivas, F, Rice, J P, Barchas, J D, Børglum, A D, Mortensen, P B, Mors, O, Grigoroiu-Serbanescu, M, Bellivier, F, Etain, B, Leboyer, M, Ramos-Quiroga, J A, Agartz, I, Amin, F, Azevedo, M H, Bass, N, Black, D W, Blackwood, D H R, Bruggeman, R, Buccola, N G, Choudhury, K, Cloninger, C R, Corvin, A, Craddock, N, Daly, M J, Datta, S, Donohoe, G J, Duan, J, Dudbridge, F, Fanous, A, Freedman, R, Freimer, N B, Friedl, M, Gill, M, Gurling, H, De Haan, L, Hamshere, M L, Hartmann, A M, Holmans, P A, Kahn, R S, Keller, M C, Kenny, E, Kirov, G K, Krabbendam, L, Krasucki, R, Lencz, T, Levinson, D F, Lieberman, J A, Lin, D Y, Linszen, D H, Magnusson, P K E, Maier, W, Malhotra, A K, Mattheisen, M, Mattingsdal, M, Mccarroll, S A, Medeiros, H, Melle, I, Milanova, V, Myin-Germeys, I, Neale, B M, Ophoff, R A, Owen, M J, Pimm, J, Purcell, S M, Puri, V, Quested, D J, Rossin, L, Sanders, A R, Shi, J, Sklar, P, St Clair, D, Stroup, T S, Van Os, J, Wiersma, D & Zammit, S 2018, ' Improving genetic prediction by leveraging genetic correlations among human diseases and traits ', Nature Communications, vol. 9, no. 1, 02769-6 . https://doi.org/10.1038/s41467-017-02769-6
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