Optimisation de la différenciation neuronale et musculaire de cellules pluripotentes induites humaines pour la modélisation des maladies rares : exemple du syndrome de DiGeorge

Autor: Badja, Cherif

Le syndrome de DiGeorge ou microdélétion 22q11.2, est la délétion chromosomique la plus fréquente chez les êtres humains. Cette délétion est liée à la recombinaison homologue non-allélique au cours de la méiose induisant la perte d’en m

Externí odkaz: http://www.theses.fr/2015AIXM5027/document

The chemotherapeutic drug CX-5461 is a potent mutagen in cultured human cells

Autor: Koh, Gene Ching Chiek, Boushaki, Soraya, Zhao, Salome Jingchen, Pregnall, Andrew Marcel, Sadiyah, Firas, Badja, Cherif, Memari, Yasin, Georgakopoulos-Soares, Ilias, Nik-Zainal, Serena

Publikováno v: Nature Genetics; January 2024, Vol. 56 Issue: 1 p23-26, 4p

Substitution mutational signatures in whole-genome-sequenced cancers in the UK population

Autor: Degasperi, Andrea, Zou, Xueqing, Amarante, Tauanne Dias, Martinez-Martinez, Andrea, Koh, Gene Ching Chiek, Dias, João ML, Heskin, Laura, Chmelova, Lucia, Rinaldi, Giuseppe, Wang, Valerie Ya Wen, Nanda, Arjun S, Bernstein, Aaron, Momen, Sophie E, Young, Jamie, Perez-Gil, Daniel, Memari, Yasin, Badja, Cherif, Shooter, Scott, Czarnecki, Jan, Brown, Matthew A, Davies, Helen R, Genomics England Research Consortium, Nik-Zainal, Serena

Whole-genome sequencing (WGS) permits comprehensive cancer genome analyses, revealing mutational signatures, imprints of DNA damage and repair processes that have arisen in each patient's cancer. We performed mutational signature analyses on 12,222 W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ed484a9586d0fd93e6447c6af4c58a
https://www.repository.cam.ac.uk/handle/1810/336115

Multilineage Differentiation for Formation of Innervated Skeletal Muscle Fibers from Healthy and Diseased Human Pluripotent Stem Cells

Autor: Mazaleyrat, Kilian, Badja, Cherif, Broucqsault, Natacha, Chevalier, Raphaël, Laberthonnière, Camille, Dion, Camille, Baldasseroni, Lyla, El-Yazidi, Claire, Thomas, Morgane, Bachelier, Richard, Altié, Alexandre, Nguyen, Karine, Levy, Nicolas, ROBIN, Jérôme, Magdinier, Frédérique

Publikováno v: Cells
Cells, MDPI, 2020, 9 (6), pp.1531. ⟨10.3390/cells9061531⟩
Volume 9
Issue 6
Cells, 2020, 9 (6), pp.1531. ⟨10.3390/cells9061531⟩
Cells, Vol 9, Iss 1531, p 1531 (2020)

Induced pluripotent stem cells (iPSCs) obtained by reprogramming primary somatic cells have revolutionized the fields of cell biology and disease modeling. However, the number protocols for generating mature muscle fibers with sarcolemmal organizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8f40fe488571bfd63316a7c35bcad562
https://hal-amu.archives-ouvertes.fr/hal-03080368

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